Synthesis and structure-activity relationship of berberine analogues in LDLR up-regulation and AMPK activation

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 22, 2012, Pages 6552-6558

  Wang, Yan Xiang ^a   Kong, Wei Jia ^a   Li, Ying Hong ^a   Tang, Sheng ^a   Li, Zheng ^a   Li, Yang Biao ^a   Shan, Yong Qiang ^a   Bi, Chong Wen ^a   Jiang, Jian Dong ^a   Song, Dan Qing ^a  

^a INSTITUTE OF MEDICINAL BIOTECHNOLOGY   (China)

Author keywords

AMPK; Berberine; LDLR; Metabolic syndrome; Structure activity relationship

Indexed keywords

1,2,3,9,10 PENTAMETHOXY 5,6 DIHYDROISOQUINOLINO[2,1 B]ISOQUINOLIN 7 IUM; 2 HYDROXYL 3,9,10 TRIMETHOXY 5,6 DIHYDROISOQUINOLINO[2,1 B]ISOQUINOLIN 7 IUM; 2,10,11 TRIMETHOXY 3 ETHOXY 5,6 DIHYDROISOQUINOLINO[2,1 B]ISOQUINOLIN 7 IUM; 2,9,10 TRIMETHOXY 3 ETHOXY 5,6 DIHYDROISOQUINOLINO[2,1 B]ISOQUINOLIN 7 IUM; 3,10,11 TRIMETHOXY 2 ETHOXY 5,6 DIHYDROISOQUINOLINO[2,1 B]ISOQUINOLIN 7 IUM; 3,4,10,11 TETRAMETHOXY 5,6 DIHYDROISOQUINOLINO[2,1 B]ISOQUINOLIN 7 IUM; 3,4,9,10 TETRAMETHOXY 5,6 DIHYDROISOQUINOLINO[2,1 B]ISOQUINOLIN 7 IUM; 3,9,10 TRIMETHOXY 2 ETHOXY 5,6 DIHYDROISOQUINOLINO[2,1 B]ISOQUINOLIN 7 IUM; 5,6 DIHYDRO 10 METHOXY 11 ETHOXY BENZO[G] 1,3 BENZODIOXOLO[5,6 A]QUINOLIZINIUM; 5,6 DIHYDRO 10 METHOXY 12 BROMO BENZO[G] 1,3 BENZODIOXOLO[5,6 A]QUINOLIZINIUM 9 OL; 5,6 DIHYDRO 10,11 (2,3 DIHYDRO[1,4]DIOXINO[2,3 G])BENZO[G] 1,3 BENZODIOXOLO[5,6 A]QUINOLIZINIUM; 5,6 DIHYDRO 9 CHLORO 10 METHOXY BENZO[G] 1,3 BENZODIOXOLO[5,6 A]QUINOLIZINIUM; 5,6 DIHYDRO 9 CHLORO 10,11 DIMETHOXY BENZO[G] 1,3 BENZODIOXOLO[5,6 A]QUINOLIZINIUM; 5,6 DIHYDRO 9 FLUORO 10 METHOXY BENZO[G] 1,3 BENZODIOXOLO[5,6 A]QUINOLIZINIUM; ADENYLATE KINASE; BERBERINE DERIVATIVE; BEROLINE; DEMETHYLENEBERBERINE; GLUCOSE; JATRORRHIZINE; LOW DENSITY LIPOPROTEIN RECEPTOR; THALIFENDINE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IN VIVO STUDY; STRUCTURE ACTIVITY RELATION; UPREGULATION;

AMP-ACTIVATED PROTEIN KINASES; BERBERINE; BERBERINE ALKALOIDS; HEP G2 CELLS; HUMANS; RECEPTORS, LDL; STRUCTURE-ACTIVITY RELATIONSHIP; UP-REGULATION;

EID: 84867876478     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.09.029     Document Type: Article

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