Impact of Metabolic Syndrome Independent of Insulin Resistance on the Development of Cardiovascular Disease

Circulation Journal

Volumn 76, Issue 10, 2012, Pages 2443-2448

  Yun, Ji Eun ^a   Won, Soyoung ^b   Sung, Jidong ^c   Jee, Sun Ha ^b  

^a Korea National Rehabilitation Research Institute   (South Korea)

^b Yonsei University   (South Korea)

^c Sungkyunkwan University School of Medicine   (South Korea)

Author keywords

Cardiovascular disease; Insulin resistance; Ischemic heart disease; Metabolic syndrome; Stroke

Indexed keywords

CHOLESTEROL; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; TRIACYLGLYCEROL;

ADULT; ALCOHOL CONSUMPTION; ARTICLE; ATHEROSCLEROTIC CARDIOVASCULAR DISEASE; BLOOD PRESSURE; BODY MASS; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CEREBROVASCULAR ACCIDENT; COHORT ANALYSIS; DISEASE ASSOCIATION; FEMALE; HUMAN; INCIDENCE; INSULIN RESISTANCE; ISCHEMIC HEART DISEASE; MALE; METABOLIC SYNDROME X; NORMAL HUMAN; PREVALENCE; PROSPECTIVE STUDY; QUESTIONNAIRE; SMOKING;

ADULT; ATHEROSCLEROSIS; FEMALE; HUMANS; INCIDENCE; INSULIN RESISTANCE; MALE; METABOLIC SYNDROME X; MIDDLE AGED; MYOCARDIAL ISCHEMIA; STROKE;

EID: 84867873850     PISSN: 13469843     EISSN: 13474820     Source Type: Journal    
DOI: 10.1253/circj.CJ-12-0125     Document Type: Article

References (35)

1. Ford ES, Giles WH, Dietz WH. Prevalence of the metabolic syndrome among US adults: Findings from the third National Health and Nutrition Examination Survey. JAMA 2002; 287: 356-359.
2. Lim S, Park KS, Lee HK, Cho SI. Changes in the characteristics of metabolic syndrome in Korea over the period 1998-2001 as determined by Korean National Health and Nutrition examination surveys. Diabetes Care 2005; 28: 1810-1812.
3. Lakka HM, Laaksonen DE, Lakka TA, Niskanen LK, Kumpusalo E, Tuomilehto J, et al. The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. JAMA 2002; 288: 2709-2716.
4. Hedblad B, Nilsson P, Engström G, Berglund G, Janzon L. Insulin resistance in nondiabetic subjects is associated with increased incidence of myocardial infarction and death. Diabet Med 2002; 19: 470-475.
5. Rutter MK, Meigs JB, Sullivan LM, D'Agostino RB Sr, Wilson PW. Insulin resistance, the metabolic syndrome, and incident cardiovascular events in the Framingham Offspring Study. Diabetes 2005; 54: 3252-3257.
6. Wilson PW, D'Agostino RB, Parise H, Sullivan L, Meigs JB. Metabolic syndrome as a precursor of cardiovascular disease and type 2 diabetes mellitus. Circulation 2005; 112: 3066-3072.
7. Sone H, Mizuno S, Fujii H, Yoshimura Y, Yamasaki Y, Ishibashi S, et al. Is the diagnosis of metabolic syndrome useful for predicting cardiovascular disease in Asian diabetic patients? Analysis from the Japan Diabetes Complications Study. Diabetes Care 2005; 28: 1463-1471.
8. Resnick HE, Jones K, Ruotolo G, Jain AK, Henderson J, Lu W, et al. Insulin resistance, the metabolic syndrome, and risk of incident cardiovascular disease in nondiabetic American indians: The Strong Heart Study. Diabetes Care 2003; 26: 861-867.
9. Kang G, Guo L, Guo Z, Hu X, Wu M, Zhou Z, et al. Impact of blood pressure and other components of the metabolic syndrome on the development of cardiovascular disease. Circ J 2010; 74: 456-461.
10. Bagry HS, Raghavendran S, Carli F. Metabolic syndrome and insulin resistance: Perioperative considerations. Anesthesiology 2008; 108: 506-523.
11. Reaven GM. Role of insulin resistance in human disease. Diabetes 1988; 37: 1595-1607.
12. Kwon CH, Kim BJ, Kim BS, Kang JH. Low-density lipoprotein cholesterol to apolipoprotein B ratio is independently associated with metabolic syndrome in Korean men. Metabolism 2011; 60: 1136-1141.
13. Kimm H, Lee SW, Lee HS, Shim KW, Cho CY, Yun JE, et al. Associations between lipid measures and metabolic syndrome, insulin resistance and adiponectin: Usefulness of lipid ratios in Korean men and women. Circ J 2010; 74: 931-937.
14. Lee YH, Shin MH, Kweon SS, Rhee JA, Ryu SY, Ahn HR, et al. Metabolic syndrome and carotid artery parameter in Koreans aged 50 years and older. Circ J 2010; 74: 560-566.
15. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412-419.
16. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 2001; 285: 2486-2497.
17. World Health Organization Western Pacific Region, International Association for the Study of Obesity and the International Obesity Task Force. The Asia-Pacific perspective: Redefining obesity and its treatment. Australia: Health Communications Australia Pty Limited, 2000.
18. Ascaso JF, Pardo S, Real JT, Lorente RI, Priego A, Carmena R. Diagnosing insulin resistance by simple quantitative methods in subjects with normal glucose metabolism. Diabetes Care 2003; 26: 3320-3325.
19. Kimm H, Yun JE, Lee SH, Jang Y, Jee SH. Validity of the diagnosis of acute myocardial infarction in Korean National Medical Health Insurance Claims data: The Korean Heart Study (1). Korean Circ J 2012; 42: 10-15.
20. Lindblad U, Langer RD, Wingard DL, Thomas RG, Barrett-Connor EL. Metabolic syndrome and ischemic heart disease in elderly men and women. Am J Epidemiol 2001; 153: 481-489.
21. Isomaa B, Almgren P, Tuomi T, Forsén B, Lahti K, Nissén M, et al. Cardiovascular morbidity and mortality associated with the metabolic syndrome. Diabetes Care 2001; 24: 683-689.
22. Resnick HE. Metabolic syndrome in American Indians. Diabetes Care 2002; 25: 1246-1247.
23. Chien KL, Hsu HC, Sung FC, Su TC, Chen MF, Lee YT. Metabolic syndrome as a risk factor for coronary heart disease and stroke: An 11-year prospective cohort in Taiwan community. Atherosclerosis 2007; 194: 214-221.
24. Hanley AJG, Williams K, Stern MP, Haffner SM. Homeostasis model assessment of insulin resistance in relation to the incidence of cardiovascular disease. Diabetes Care 2002; 25: 1177-1184.
25. Bonora E, Formentini G, Calcaterra F, Lombardi S, Marini F, Zenari L, et al. HOMA-estimated insulin resistance is an independent predictor of cardiovascular disease in type 2 diabetic subjects. Diabetes Care 2002; 25: 1135-1141.
26. Onat A, Hergenç G, Türkmen S, Yazici M, Sari I, Can G. Discordance between insulin resistance and metabolic syndrome: Features and associated cardiovascular risk in adults with normal glucose regulation. Metabolism 2006; 55: 445-452.
27. Lann D, LeRoith D. Insulin resistance as the underlying cause for the metabolic syndrome. Med Clin North Am 2007; 91: 1063-1077.
28. Grundy SM, Brewer HB Jr, Cleeman JI, Smith SC Jr, Lenfant C. Definition of metabolic syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Circulation 2004; 109: 433-438.
29. McNeil AM, Rosamond WD, Girman CJ, Heiss G, Golden SH, Duncan BB, et al. Prevalence of coronary heart disease and carotid arterial thickening in patients with the metabolic syndrome (the ARIC study). Am J Cardiol 2004; 94: 1249-1254.
30. Ellison RC, Shang Y, Wagenknecht LE, Eckfeldt JH, Hopkins PN, Pankow JS, et al. Relation of the metabolic syndrome to calcified atherosclerotic plaque in the coronary arteries and aorta. Am J Cardiol 2005; 95: 1180-1186.
31. Bertoni AG, Wong ND, Shea S, Ma S, Liu K, Preethi S, et al. Insulin resistance, metabolic syndrome, and subclinical atherosclerosis: The Multi-Ethnic Study of Atherosclerosis (MESA). Diabetes Care 2007; 30: 2951-2956.
32. Tzou WS, Douglas PS, Srinivasan SR, Bond MG, Tang R, Chen W, et al. Increased subclinical atherosclerosis in young adults with metabolic syndrome: The Bogalusa Heart Study. J Am Coll Cardiol 2005; 46: 457-463.
33. Jeppesen J, Hansen TW, Rasmussen S, Ibsen H, Torp-Pedersen C, Madsbad S. Insulin resistance, the metabolic syndrome, and risk of incident cardiovascular disease: A population-based study. J Am Coll Cardiol 2007; 49: 2112-2119.
34. Bonora E, Targher G, Alberiche M, Bonadonna RC, Saggiani F, Zenere MB, et al. Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity. Diabetes Care 2000; 23: 57-63.
35. Trevisan M, Liu J, Muti P, Misciagna G, Menotti A, Fucci F. Markers of insulin resistance and colorectal cancer mortality. Cancer Epidemiol Biomarkers Prev 2001; 10: 937-941.