Synthesis and SAR of geminal substitutions at the C5′ carbosugar position of pyrimidine-derived HCV inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 22, 2012, Pages 6967-6973

  Verma, Vishal A ^a   Rossman, Randall ^a   Bennett, Frank ^a   Chen, Lei ^a   Gavalas, Stephen ^a   Girijavallabhan, Vinay ^a   Huang, Yuhua ^a   Kim, Seong Heon ^a   Kosinski, Aneta ^a   Pinto, Patrick ^a   Rizvi, Razia ^a   Shankar, Bandarpalle ^a   Tong, Ling ^a   Velazquez, Francisco ^a   Venkatraman, Srikanth ^a   Kozlowski, Joseph ^a   MacCoss, Malcolm ^a   Kwong, Cecil D ^b   Bansal, Namita ^b   Kezar III, Hollis S ^b   Reynolds, Robert C ^b   Maddry, Joseph A ^b   Ananthan, Subramaniam ^b   Secrist III, John A ^b   Li, Cheng ^a   Chase, Robert ^a   Curry, Stephanie ^a   Huang, Hsueh Cheng ^a   Tong, Xiao ^a   Njoroge, F George ^a   Arasappan, Ashok ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

^b SOUTHERN RESEARCH INSTITUTE   (United States)

Author keywords

Carbosugar; Geminal substitution; HCV inhibitor; Hepatitis C virus

Indexed keywords

ANTIVIRUS AGENT; HEPATITIS C VIRUS INHIBITOR; PYRIMIDINE; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; HEPATITIS C VIRUS; STRUCTURE ACTIVITY RELATION; VIRUS INHIBITION;

ANIMALS; ANTIVIRAL AGENTS; BIOLOGICAL AVAILABILITY; CARBOHYDRATES; DOGS; HALF-LIFE; HAPLORHINI; HEPACIVIRUS; PYRIMIDINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; VIRUS REPLICATION;

HEPATITIS C VIRUS; RODENTIA;

EID: 84867867229     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.08.111     Document Type: Article

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