Pyridofuran substituted pyrimidine derivatives as HCV replication (replicase) inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 15, 2012, Pages 5144-5149

  Bennett, Frank ^a   Kezar III, Hollis S ^b   Girijavallabhan, Vinay ^a   Huang, Yuhua ^a   Huelgas, Regina ^a   Rossman, Randall ^a   Shih, Neng Yang ^a   Piwinski, John J ^a   MacCoss, Malcolm ^a   Kwong, Cecil D ^b   Clark, Jeremy L ^b   Fowler, Anita T ^b   Geng, Feng ^b   Roychowdhury, Abhijit ^b   Reynolds, Robert C ^b   Maddry, Joseph A ^b   Ananthan, Subramaniam ^b   Secrist III, John A ^b   Li, Cheng ^a   Chase, Robert ^a   Curry, Stephanie ^a   Huang, Hsueh Cheng ^a   Tong, Xiao ^a   George Njoroge, F ^a   Arasappan, Ashok ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

^b SOUTHERN RESEARCH INSTITUTE   (United States)

Author keywords

5 Aryl pyrimidine; 5 Pyridofuranyl pyrimidine; Carbanucleoside like; HCV replicase inhibitor; HCV replication inhibitor; Hepatitis

Indexed keywords

BENZOFURAN DERIVATIVE; BENZOFURAN INHIBITOR; BOCEPREVIR; PYRIMIDINE DERIVATIVE; RNA DIRECTED RNA POLYMERASE INHIBITOR; TELAPREVIR; UNCLASSIFIED DRUG;

ALKYLATION; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; DRUG HALF LIFE; DRUG STRUCTURE; DRUG SYNTHESIS; HEPATITIS C; METHYLATION; NONHUMAN; RAT; VIRUS INHIBITION;

ANIMALS; ANTIVIRAL AGENTS; BENZOFURANS; ENZYME INHIBITORS; FURANS; HALF-LIFE; HEPACIVIRUS; LIVER; PYRIMIDINE NUCLEOSIDES; PYRIMIDINES; RATS; RNA REPLICASE; STRUCTURE-ACTIVITY RELATIONSHIP; VIRUS REPLICATION;

HEPATITIS C VIRUS;

EID: 84863908695     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.06.021     Document Type: Article

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