Altered vascular function, arterial stiffness, and antioxidant gene responses in pediatric thalassemia patients

Pediatric Cardiology

Volumn 33, Issue 7, 2012, Pages 1054-1060

  Detchaporn, Pantipa ^a   Kukongviriyapan, Upa ^a   Prawan, Auemduan ^a   Jetsrisuparb, Arunee ^a   Greenwald, Stephen E ^b   Kukongviriyapan, Veerapol ^a  

^a KHON KAEN UNIVERSITY   (Thailand)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Antioxidant gene; Arterial stiffness; Endothelial dysfunction; Oxidative stress; Pulse wave velocity; Thalassemia

Indexed keywords

BIOLOGICAL MARKER; CARBONYL DERIVATIVE; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; HEME OXYGENASE 1; HEMOGLOBIN E; IRON; MALONALDEHYDE; MESSENGER RNA; THIOREDOXIN; TRANSFERRIN;

ADAPTATION; ADOLESCENT; ARM BLOOD FLOW; ARTERIAL STIFFNESS; ARTICLE; BETA THALASSEMIA; CELL PROTECTION; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENDOTHELIAL DYSFUNCTION; FEMALE; HOST CELL; HUMAN; HYPEREMIA; LEG; MALE; MONONUCLEAR CELL; OXIDATIVE STRESS; PRESCHOOL CHILD; PULSE WAVE; TRUNK; UPREGULATION;

ADOLESCENT; ANTIOXIDANTS; BETA-THALASSEMIA; BIOLOGICAL MARKERS; BLOOD FLOW VELOCITY; CASE-CONTROL STUDIES; CHILD; ENDOTHELIUM, VASCULAR; FEMALE; FOREARM; GENE EXPRESSION; HEMOGLOBIN E; HUMANS; LINEAR MODELS; MALE; MALONDIALDEHYDE; OXIDATIVE STRESS; POLYMERASE CHAIN REACTION; PROTEIN CARBONYLATION; STATISTICS, NONPARAMETRIC; ULTRASONOGRAPHY, DOPPLER; VASCULAR STIFFNESS;

EID: 84867863675     PISSN: 01720643     EISSN: 14321971     Source Type: Journal    
DOI: 10.1007/s00246-012-0225-8     Document Type: Article

References (28)

1. Aessopos A, Farmakis D, Hatziliami A, Fragodimitri C, Karabatsos F, Joussef J et al (2004) Cardiac status in well-treated patients with thalassemia major. Eur J Haematol 73:359-366
2. Aessopos A, Farmakis D, Tsironi M, Diamanti-Kandarakis E, Matzourani M, Fragodimiri C et al (2007) Endothelial function and arterial stiffness in sickle-thalassemia patients. Atherosclerosis 191:427-432
3. Aggeli C, Antoniades C, Cosma C, Chrysohoou C, Tousoulis D, Ladis V et al (2005) Endothelial dysfunction and inflammatory process in transfusion- dependent patients with beta-thalassemia major. Int J Cardiol 105:80-84
4. Aronson D (2003) Cross-linking of glycated collagen in the pathogenesis of arterial and myocardial stiffening of aging and diabetes. J Hypertens 21:3-12
5. Atkinson J (2008) Age-related medial elastocalcinosis in arteries: mechanisms, animal models, and physiological consequences. J Appl Physiol 105:1643-1651
6. Butthep P, Bunyaratvej A, Funahara Y, Kitaguchi H, Fucharoen S, Sato S et al (1995) Alterations in vascular endothelial cellrelated plasma proteins in thalassaemic patients and their correlation with clinical symptoms. Thromb Haemost 74:1045-1049
7. Chakraborty D, Bhattacharyya M (2001) Antioxidant defense status of red blood cells of patients with beta-thalassemia and Ebeta-thalassemia. Clin Chim Acta 305:123-129
8. Cheung YF, Chan GC, Ha SY (2002) Arterial stiffness and endothelial function in patients with beta-thalassemia major. Circulation 106:2561-2566
9. Cunningham MJ, Macklin EA, Neufeld EJ, Cohen AR (2004) Complications of beta-thalassemia major in North America. Blood 104:34-39
10. Dhakshinamoorthy S, Jain AK, Bloom DA, Jaiswal AK (2005) Bach1 competes with Nrf2 leading to negative regulation of the antioxidant response element (ARE)-mediated NAD(P)H:quinone oxidoreductase 1 gene expression and induction in response to antioxidants. J Biol Chem 280:16891-16900
11. Domenica Cappellini M, Tavazzi D, Duca L, Marelli S, Fiorelli G (2000) Non-transferrin-bound iron, iron-related oxidative stress, and lipid peroxidation in beta-thalassemia intermedia. Transfus Sci 23:245-246
12. Farombi EO, Surh YJ (2006) Heme oxygenase-1 as a potential therapeutic target for hepatoprotection. J Biochem Mol Biol 39:479-491
13. Hahalis G, Alexopoulos D, Kremastinos DT, Zoumbos NC (2005) Heart failure in beta-thalassemia syndromes: a decade of progress. Am J Med 118:957-967
14. Jeyapaul J, Jaiswal AK (2000) Nrf2 and c-Jun regulation of antioxidant response element (ARE)-mediated expression and induction of gamma- glutamylcysteine synthetase heavy subunit gene. Biochem Pharmacol 59:1433-1439
15. Jison ML, Munson PJ, Barb JJ, Suffredini AF, Talwar S, Logun C et al (2004) Blood mononuclear cell gene expression profiles characterize the oxidant, hemolytic, and inflammatory stress of sickle cell disease. Blood 104:270-280
16. Jittangprasert P, Wilairat P, Pootrakul P (2004) Comparison of colorimetry and electrothermal atomic absorption spectroscopy for the quantification of non-transferrin-bound iron in human sera. Southeast Asian J Trop Med Public Health 35:1039-1044
17. Jones DP, Go YM, Anderson CL, Ziegler TR, Kinkade JM Jr., Kirlin WG (2004) Cysteine/cystine couple is a newly recognized node in the circuitry for biologic redox signaling and control. FASEB J 18:1246-1248
18. Kukongviriyapan V, Somparn N, Senggunprai L, Prawan A, Kukongviriyapan U, Jetsrisuparb A (2008) Endothelial dysfunction and oxidant status in pediatric patients with hemoglobin E-beta thalassemia. Pediatr Cardiol 29:130-135
19. Laurent S, Katsahian S, Fassot C, Tropeano AI, Gautier I, Laloux B et al (2003) Aortic stiffness is an independent predictor of fatal stroke in essential hypertension. Stroke 34:1203-1206
20. Loukogeorgakis S, Dawson R, Phillips N, Martyn CN, Greenwald SE (2002) Validation of a device to measure arterial pulse wave velocity by a photoplethysmographic method. Physiol Meas 23:581-596
21. Mattace-Raso FU, van der Cammen TJ, Hofman A, van Popele NM, Bos ML, Schalekamp MA et al (2006) Arterial stiffness and risk of coronary heart disease and stroke: the Rotterdam study. Circulation 113:657-663
22. Naka KK, Tweddel AC, Doshi SN, Goodfellow J, Henderson AH (2006) Flow-mediated changes in pulse-wave velocity: a new clinical measure of endothelial function. Eur Heart J 27:302-309
23. Nguyen T, Yang CS, Pickett CB (2004) The pathways and molecular mechanisms regulating Nrf2 activation in response to chemical stress. Free Radic Biol Med 37:433-441
24. Olivieri NF (1999) The beta-thalassemias. N Engl J Med 341:99-109
25. Ryter SW, Alam J, Choi AM (2006) Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications. Physiol Rev 86:583-650
26. Somparn N, Kukongviriyapan U, Tassaneeyakul W, Jetsrisuparb A, Kukongviriyapan V (2007) Modification of CYP2E1 and CYP3A4 activities in haemoglobin E-beta thalassemia patients. Eur J Clin Pharmacol 63:43-50
27. Surh YJ, Kundu JK, Li MH, Na HK, Cha YN (2009) Role of Nrf2-mediated heme oxygenase-1 upregulation in adaptive survival response to nitrosative stress. Arch Pharm Res 32:1163-1176
28. Weatherall DJ (2000) Introduction to the problem of hemoglobin E-beta thalassemia. J Pediatr Hematol Oncol 22:551