AT motif binding factor 1 (ATBF1) is highly phosphorylated in embryonic brain and protected from cleavage by calpain-1

Biochemical and Biophysical Research Communications

Volumn 427, Issue 3, 2012, Pages 537-541

  Zhang, Sheng ^a,b,c   Kim, Tae Sun ^b,d   Dong, Yu ^b   Kanazawa, Satoshi ^b   Kawaguchi, Makoto ^b,e   Gao, Nan ^b,f   Minato, Hiroshi ^a   Takegami, Tsutomu ^a   Nojima, Takayuki ^a   Asai, Kiyofumi ^b   Miura, Yutaka ^b  

^a KANAZAWA MEDICAL UNIVERSITY   (Japan)

^b NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

^c CHINA MEDICAL UNIVERSITY   (China)

^d UNIVERSITY OF CALGARY   (Canada)

^e Japan Organization of Occupational Health and Safety   (Japan)

^f Novartis Pharma AG   (China)

Author keywords

ATBF1; Calpain 1; FK506; Phosphorylation; Protein stability; ZFHX3

Indexed keywords

ALKALINE PHOSPHATASE; AT MOTIF BINDING FACTOR 1; CALCINEURIN; CALPAIN 1; SERINE; TACROLIMUS; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BRAIN LEVEL; COMPARATIVE STUDY; CONTROLLED STUDY; EMBRYO; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY;

ANIMALS; BRAIN; CALCINEURIN; CALPAIN; FEMALE; HOMEODOMAIN PROTEINS; MICE; MICE, INBRED ICR; PHOSPHORYLATION; PROTEIN STABILITY; PROTEOLYSIS; SERINE PROTEINASE INHIBITORS; TACROLIMUS;

EID: 84867848556     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.09.092     Document Type: Article

References (27)

1. Miura Y., Tam T., Ido A., Morinaga T., Miki T., Hashimoto T., Tamaoki T. Cloning and characterization of an ATBF1 isoform that expresses in a neuronal differentiation-dependent manner. J. Biol. Chem. 1995, 270:26840-26848.
2. Morinaga T., Yasuda H., Hashimoto T., Higashio K., Tamaoki T. A human alpha-fetoprotein enhancer-binding protein, ATBF1, contains four homeodomains and seventeen zinc fingers. Mol. Cell. Biol. 1991, 11:6041-6049.
3. Ishii Y., Kawaguchi M., Takagawa K., Oya T., Nogami S., Tamura A., Miura Y., Ido A., Sakata N., Hashimoto-Tamaoki T., Kimura T., Saito T., Tamaoki T., Sasahara M. ATBF1-A protein, but not ATBF1-B, is preferentially expressed in developing rat brain. J. Comp. Neurol. 2003, 465:57-71.
4. Jung C.G., Kim H.J., Kawaguchi M., Khanna K.K., Hida H., Asai K., Nishino H., Miura Y. Homeotic factor ATBF1 induces the cell cycle arrest associated with neuronal differentiation. Development 2005, 132:5137-5145.
5. Sun X., Frierson H.F., Chen C., Li C., Ran Q., Otto K.B., Cantarel B.L., Vessella R.L., Gao A.C., Petros J., Miura Y., Simons J.W., Dong J.T. Frequent somatic mutations of the transcription factor ATBF1 in human prostate cancer. Nat. Genet. 2005, 37:407-412.
6. Kataoka H., Miura Y., Joh T., Seno K., Tada T., Tamaoki T., Nakabayashi H., Kawaguchi M., Asai K., Kato T., Itoh M. Alpha-fetoprotein producing gastric cancer lacks transcription factor ATBF1. Oncogene 2001, 20:869-873.
7. Miura Y., Kataoka H., Joh T., Tada T., Asai K., Nakanishi M., Okada N., Okada H. Susceptibility to killer T cells of gastric cancer cells enhanced by Mitomycin-C involves induction of ATBF1 and activation of p21 (Waf1/Cip1) promoter. Microbiol. Immunol. 2004, 48:137-145.
8. Mabuchi M., Kataoka H., Miura Y., Kim T.S., Kawaguchi M., Ebi M., Tanaka M., Mori Y., Kubota E., Mizushima T., Shimura T., Mizoshita T., Tanida S., Kamiya T., Asai K., Joh T. Tumor suppressor, AT motif binding factor 1 (ATBF1), translocates to the nucleus with runt domain transcription factor 3 (RUNX3) in response to TGF-beta signal transduction. Biochem. Biophys. Res. Commun. 2010, 398:321-325.
9. Kim C.J., Song J.H., Cho Y.G., Cao Z., Lee Y.S., Nam S.W., Lee J.Y., Park W.S. Down-regulation of ATBF1 is a major inactivating mechanism in hepatocellular carcinoma. Histopathology 2008, 52:552-559.
10. Zhang Z., Yamashita H., Toyama T., Sugiura H., Ando Y., Mita K., Hamaguchi M., Kawaguchi M., Miura Y., Iwase H. ATBF1-a messenger RNA expression is correlated with better prognosis in breast cancer. Clin. Cancer Res. 2005, 11:193-198.
11. Kai K., Zhang Z., Yamashita H., Yamamoto Y., Miura Y., Iwase H. Loss of heterozygosity at the ATBF1-A locus located in the 16q22 minimal region in breast cancer. BMC Cancer 2008, 8:262.
12. Dong X.Y., Sun X., Guo P., Li Q., Sasahara M., Ishii Y., Dong J.T. ATBF1 inhibits estrogen receptor (ER) function by selectively competing with AIB1 for binding to the ER in ER-positive breast cancer cells. J. Biol. Chem. 2010, 285:32801-32809.
13. Chen Y., Takita J., Choi Y.L., Kato M., Ohira M., Sanada M., Wang L., Soda M., Kikuchi A., Igarashi T., Nakagawara A., Hayashi Y., Mano H., Ogawa S. Oncogenic mutations of ALK kinase in neuroblastoma. Nature 2008, 455:971-974.
14. Burgner D., Davila S., Breunis W.B., Ng S.B., Li Y., Bonnard C., Ling L., Wright V.J., Thalamuthu A., Odam M., Shimizu C., Burns J.C., Levin M., Kuijpers T.W., Hibberd M.L. A genome-wide association study identifies novel and functionally related susceptibility Loci for Kawasaki disease. PLoS Genet. 2009, 5:e1000319.
15. Benjamin E.J., Rice K.M., Arking D.E., Pfeufer A., van Noord C., Smith A.V., Schnabel R.B., Bis J.C., Boerwinkle E., Sinner M.F., Dehghan A., Lubitz S.A., D'Agostino R.B., Lumley T., Ehret G.B., Heeringa J., Aspelund T., Newton-Cheh C., Larson M.G., Marciante K.D., Soliman E.Z., Rivadeneira F., Wang T.J., Eiriksdottir G., Levy D., Psaty B.M., Li M., Chamberlain A.M., Hofman A., Vasan R.S., Harris T.B., Rotter J.I., Kao W.H., Agarwal S.K., Stricker B.H., Wang K., Launer L.J., Smith N.L., Chakravarti A., Uitterlinden A.G., Wolf P.A., Sotoodehnia N., Kottgen A., van Duijn C.M., Meitinger T., Mueller M., Perz S., Steinbeck G., Wichmann H.E., Lunetta K.L., Heckbert S.R., Gudnason V., Alonso A., Kaab S., Ellinor P.T., Witteman J.C. Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry. Nat. Genet. 2009, 41:879-881.
16. Gudbjartsson D.F., Holm H., Gretarsdottir S., Thorleifsson G., Walters G.B., Thorgeirsson G., Gulcher J., Mathiesen E.B., Njolstad I., Nyrnes A., Wilsgaard T., Hald E.M., Hveem K., Stoltenberg C., Kucera G., Stubblefield T., Carter S., Roden D., Ng M.C., Baum L., So W.Y., Wong K.S., Chan J.C., Gieger C., Wichmann H.E., Gschwendtner A., Dichgans M., Kuhlenbaumer G., Berger K., Ringelstein E.B., Bevan S., Markus H.S., Kostulas K., Hillert J., Sveinbjornsdottir S., Valdimarsson E.M., Lochen M.L., Ma R.C., Darbar D., Kong A., Arnar D.O., Thorsteinsdottir U., Stefansson K. A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke. Nat. Genet. 2009, 41:876-878.
17. Bowden N.A., Scott R.J., Tooney P.A. Altered gene expression in the superior temporal gyrus in schizophrenia. BMC Genomics 2008, 9:199.
18. Kim T.S., Kawaguchi M., Suzuki M., Jung C.G., Asai K., Shibamoto Y., Lavin M.F., Khanna K.K., Miura Y. The ZFHX3 (ATBF1) transcription factor induces PDGFRB, which activates ATM in the cytoplasm to protect cerebellar neurons from oxidative stress. Dis. Model. Mech. 2010.
19. Varughese K.I., Ahmed F.R., Carey P.R., Hasnain S., Huber C.P., Storer A.C. Crystal structure of a papain-E-64 complex. Biochemistry 1989, 28:1330-1332.
20. Lankiewicz S., Marc Luetjens C., Truc Bui N., Krohn A.J., Poppe M., Cole G.M., Saido T.C., Prehn J.H. Activation of calpain I converts excitotoxic neuron death into a caspase-independent cell death. J. Biol. Chem. 2000, 275:17064-17071.
21. Higuchi M., Iwata N., Matsuba Y., Takano J., Suemoto T., Maeda J., Ji B., Ono M., Staufenbiel M., Suhara T., Saido T.C. Mechanistic involvement of the calpain-calpastatin system in Alzheimer neuropathology. FASEB J. 2011.
22. Li Y., Bondada V., Joshi A., Geddes J.W. Calpain 1 and calpastatin expression is developmentally regulated in rat brain. Exp. Neurol. 2009, 220:316-319.
23. Cuerrier D., Moldoveanu T., Davies P.L. Determination of peptide substrate specificity for mu-calpain by a peptide library-based approach: the importance of primed side interactions. J. Biol. Chem. 2005, 280:40632-40641.
24. Kamei H., Saito T., Ozawa M., Fujita Y., Asada A., Bibb J.A., Saido T.C., Sorimachi H., Hisanaga S. Suppression of calpain-dependent cleavage of the CDK5 activator p35 to p25 by site-specific phosphorylation. J. Biol. Chem. 2007, 282:1687-1694.
25. Hong H.S., Hwang J.Y., Son S.M., Kim Y.H., Moon M., Inhee M.J. FK506 reduces amyloid plaque burden and induces MMP-9 in AbetaPP/PS1 double transgenic mice. J. Alzheimers Dis. 2010, 22:97-105.
26. Thornberry N.A., Rano T.A., Peterson E.P., Rasper D.M., Timkey T., Garcia-Calvo M., Houtzager V.M., Nordstrom P.A., Roy S., Vaillancourt J.P., Chapman K.T., Nicholson D.W. A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis. J. Biol. Chem. 1997, 272:17907-17911.
27. Takadera T., Ohyashiki T. Apoptotic cell death and caspase 3 (CPP32) activation induced by calcium ionophore at low concentrations and their prevention by nerve growth factor in PC12 cells. Eur. J. Biochem. 1997, 249:8-12.