Regulation of OCT4 gene expression by liver receptor homolog-1 in human embryonic carcinoma cells

Biochemical and Biophysical Research Communications

Volumn 427, Issue 2, 2012, Pages 315-320

  Sung, BoReum ^a   Do, Hyun Jin ^a   Park, Sung Won ^a   Huh, Sun Hyung ^a   Oh, Jong Hyun ^b   Chung, Hak Jae ^c   Kang, Man Jong ^d   Kim, Jin Hoi ^e   Kim, Nam Hyung ^f   Kim, Jae Hwan ^a  

^a CHA University   (South Korea)

^b Ace Highend Tower   (South Korea)

^c National Institute of Animal Science   (South Korea)

^d Chonnam National University   (South Korea)

^e Konkuk University   (South Korea)

^f Chungbuk National University   (South Korea)

Author keywords

Human OCT4 promoter; LRH 1; NCCIT cells; Transcriptional activity

Indexed keywords

LIVER RECEPTOR HOMOLOG 1; OCTAMER TRANSCRIPTION FACTOR 4; RETINOIC ACID;

ARTICLE; BINDING SITE; CELL DIFFERENTIATION; DOWN REGULATION; EMBRYONAL CARCINOMA STEM CELL; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MUTAGENESIS; PRIORITY JOURNAL;

BINDING SITES; CARCINOMA, EMBRYONAL; CELL LINE, TUMOR; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; OCTAMER TRANSCRIPTION FACTOR-3; PROMOTER REGIONS, GENETIC; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION; TRETINOIN;

EID: 84867847977     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.09.049     Document Type: Article

References (40)

1. Okamoto K., Okazawa H., Okuda A., Sakai M., Muramatsu M., Hamada H. A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells. Cell 1990, 60:461-472.
2. Rosner M.H., Vigano M.A., Ozato K., Timmons P.M., Poirier F., Rigby P.W., Staudt L.M. A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo. Nature 1990, 345:686-692.
3. Niwa H., Miyazaki J., Smith A.G. Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat. Genet. 2000, 24:372-376.
4. Ben-Shushan E., Sharir H., Pikarsky E., Bergman Y. A dynamic balance between ARP-1/COUP-TFII, EAR-3/COUP-TFI, and retinoic acid receptor:retinoid X receptor heterodimers regulates Oct-3/4 expression in embryonal carcinoma cells. Mol. Cell. Biol. 1995, 15:1034-1048.
5. Minucci S., Botquin V., Yeom Y.I., Dey A., Sylvester I., Zand D.J., Ohbo K., Ozato K., Scholer H.R. Retinoic acid-mediated down-regulation of Oct3/4 coincides with the loss of promoter occupancy in vivo. EMBO J. 1996, 15:888-899.
6. Looijenga L.H., Stoop H., de Leeuw H.P., de Gouveia Brazao C.A., Gillis A.J., van Roozendaal K.E., van Zoelen E.J., Weber R.F., Wolffenbuttel K.P., van Dekken H., Honecker F., Bokemeyer C., Perlman E.J., Schneider D.T., Kononen J., Sauter G., Oosterhuis J.W. POU5F1 (OCT3/4) identifies cells with pluripotent potential in human germ cell tumors. Cancer Res. 2003, 63:2244-2250.
7. Ezeh U.I., Turek P.J., Reijo R.A., Clark A.T. Human embryonic stem cell genes OCT4, NANOG, STELLAR, and GDF3 are expressed in both seminoma and breast carcinoma. Cancer 2005, 104:2255-2265.
8. Atlasi Y., Mowla S.J., Ziaee S.A., Bahrami A.R. OCT-4, an embryonic stem cell marker, is highly expressed in bladder cancer. Int. J. Cancer 2007, 120:1598-1602.
9. Al-Hajj M., Clarke M.F. Self-renewal and solid tumor stem cells. Oncogene 2004, 23:7274-7282.
10. Tai M.H., Chang C.C., Kiupel M., Webster J.D., Olson L.K., Trosko J.E. Oct4 expression in adult human stem cells: evidence in support of the stem cell theory of carcinogenesis. Carcinogenesis 2005, 26:495-502.
11. Chang C.C., Shieh G.S., Wu P., Lin C.C., Shiau A.L., Wu C.L. Oct-3/4 expression reflects tumor progression and regulates motility of bladder cancer cells. Cancer Res. 2008, 68:6281-6291.
12. Du Z., Jia D., Liu S., Wang F., Li G., Zhang Y., Cao X., Ling E.A., Hao A. Oct4 is expressed in human gliomas and promotes colony formation in glioma cells. Glia 2009, 57:724-733.
13. Borrull A., Ghislin S., Deshayes F., Lauriol J., Alcaide-Loridan C., Middendorp S. Nanog and Oct4 overexpression increases motility and transmigration of melanoma cells. J. Cancer Res. Clin. Oncol. 2012, 138:1145-1154.
14. Takeda J., Seino S., Bell G.I. Human Oct3 gene family: cDNA sequences, alternative splicing, gene organization, chromosomal location, and expression at low levels in adult tissues. Nucleic Acids Res. 1992, 20:4613-4620.
15. Nordhoff V., Hubner K., Bauer A., Orlova I., Malapetsa A., Scholer H.R. Comparative analysis of human, bovine, and murine Oct-4 upstream promoter sequences. Mamm. Genome 2001, 12:309-317.
16. Yang H.M., Do H.J., Oh J.H., Kim J.H., Choi S.Y., Cha K.Y., Chung H.M. Characterization of putative cis-regulatory elements that control the transcriptional activity of the human Oct4 promoter. J. Cell. Biochem. 2005, 96:821-830.
17. Barnea E., Bergman Y. Synergy of SF1 and RAR in activation of Oct-3/4 promoter. J. Biol. Chem. 2000, 275:6608-6619.
18. Fuhrmann G., Chung A.C., Jackson K.J., Hummelke G., Baniahmad A., Sutter J., Sylvester I., Scholer H.R., Cooney A.J. Mouse germline restriction of Oct4 expression by germ cell nuclear factor. Dev. Cell 2001, 1:377-387.
19. Gu P., Goodwin B., Chung A.C., Xu X., Wheeler D.A., Price R.R., Galardi C., Peng L., Latour A.M., Koller B.H., Gossen J., Kliewer S.A., Cooney A.J. Orphan nuclear receptor LRH-1 is required to maintain Oct4 expression at the epiblast stage of embryonic development. Mol. Cell. Biol. 2005, 25:3492-3505.
20. Yang H.M., Do H.J., Kim D.K., Park J.K., Chang W.K., Chung H.M., Choi S.Y., Kim J.H. Transcriptional regulation of human Oct4 by steroidogenic factor-1. J. Cell. Biochem. 2007, 101:1198-1209.
21. Fayard E., Auwerx J., Schoonjans K. LRH-1: an orphan nuclear receptor involved in development, metabolism and steroidogenesis. Trends Cell Biol. 2004, 14:250-260.
22. Nitta M., Ku S., Brown C., Okamoto A.Y., Shan B. CPF: an orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7alpha-hydroxylase gene. Proc. Nat. Acad. Sci. USA 1999, 96:6660-6665.
23. Ueda H., Sun G.C., Murata T., Hirose S. A novel DNA-binding motif abuts the zinc finger domain of insect nuclear hormone receptor FTZ-F1 and mouse embryonal long terminal repeat-binding protein. Mol. Cell. Biol. 1992, 12:5667-5672.
24. Freeman L.A., Kennedy A., Wu J., Bark S., Remaley A.T., Santamarina-Fojo S., Brewer H.B. The orphan nuclear receptor LRH-1 activates the ABCG5/ABCG8 intergenic promoter. J. Lipid Res. 2004, 45:1197-1206.
25. Fayard E., Schoonjans K., Annicotte J.S., Auwerx J. Liver receptor homolog 1 controls the expression of carboxyl ester lipase. J. Biol. Chem. 2003, 278:35725-35731.
26. Shin D.J., Osborne T.F. Peroxisome proliferator-activated receptor-gamma coactivator-1alpha activation of CYP7A1 during food restriction and diabetes is still inhibited by small heterodimer partner. J. Biol. Chem. 2008, 283:15089-15096.
27. Lazarus K.A., Wijayakumara D., Chand A.L., Simpson E.R., Clyne C.D. Therapeutic potential of liver receptor homolog-1 modulators. J. Steroid Biochem. Mol. Biol. 2012, 130:138-146.
28. Yazawa T., Inanoka Y., Mizutani T., Kuribayashi M., Umezawa A., Miyamoto K. Liver receptor homolog-1 regulates the transcription of steroidogenic enzymes and induces the differentiation of mesenchymal stem cells into steroidogenic cells. Endocrinology 2009, 150:3885-3893.
29. Wang S.L., Zheng D.Z., Lan F.H., Deng X.J., Zeng J., Li C.J., Wang R., Zhu Z.Y. Increased expression of hLRH-1 in human gastric cancer and its implication in tumorigenesis. Mol. Cell. Biochem. 2008, 308:93-100.
30. Benod C., Vinogradova M.V., Jouravel N., Kim G.E., Fletterick R.J., Sablin E.P. Nuclear receptor liver receptor homologue 1 (LRH-1) regulates pancreatic cancer cell growth and proliferation. Proc. Nat. Acad. Sci. USA 2011, 108:16927-16931.
31. Chand A.L., Herridge K.A., Thompson E.W., Clyne C.D. The orphan nuclear receptor LRH-1 promotes breast cancer motility and invasion. Endocr. Relat. Cancer 2010, 17:965-975.
32. Damjanov I., Horvat B., Gibas Z. Retinoic acid-induced differentiation of the developmentally pluripotent human germ cell tumor-derived cell line, NCCIT. Lab. Invest. 1993, 68:220-232.
33. Lim H.Y., Do H.J., Lee W.Y., Kim D.K., Seo H.G., Chung H.J., Park J.K., Chang W.K., Kim J.H. Implication of human OCT4 transactivation domains for self-regulatory transcription. Biochem. Biophys. Res. Commun. 2009, 385:148-153.
34. Galarneau L., Pare J.F., Allard D., Hamel D., Levesque L., Tugwood J.D., Green S., Belanger L. The alpha1-fetoprotein locus is activated by a nuclear receptor of the drosophila FTZ-F1 family. Mol. Cell. Biol. 1996, 16:3853-3865.
35. Park S.W., Lim H.Y., Do H.J., Sung B.R., Huh S.H., Uhm S.J., Song H., Chung H.J., Kim J.H., Kim N.H., Kim J.H. Regulation of human growth and differentiation factor 3 gene expression by NANOG in human embryonic carcinoma NCCIT cells. FEBS Lett. 2012, 586:3529-3535.
36. Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001, 25:402-408.
37. Do H.J., Lee W.Y., Lim H.Y., Oh J.H., Kim D.K., Kim J.H., Kim T. Two potent transactivation domains in the C-terminal region of human NANOG mediate transcriptional activation in human embryonic carcinoma cells. J. Cell. Biochem. 2009, 106:1079-1089.
38. Mendelsohn C., Ruberte E., Chambon P. Retinoid receptors in vertebrate limb development. Dev. Biol. 1992, 152:50-61.
39. Jonk L.J., Itoh S., Heldin C.H., ten Dijke P., Kruijer W. Identification and functional characterization of a Smad binding element (SBE) in the JunB promoter that acts as a transforming growth factor-beta, activin, and bone morphogenetic protein-inducible enhancer. J. Biol. Chem. 1998, 273:21145-21152.
40. Oh J.H., Do H.J., Yang H.M., Moon S.Y., Cha K.Y., Chung H.M., Kim J.H. Identification of a putative transactivation domain in human nanog. Exp. Mol. Med. 2005, 37:250-254.