Modeling the yew tree tubulin and a comparison of its interaction with paclitaxel to human tubulin

Pharmaceutical Research

Volumn 29, Issue 11, 2012, Pages 3007-3021

  Tuszynski, Jack A ^a,d   Craddock, Travis J A ^a   Mane, Jonathan Y ^a   Barakat, Khaled ^a,b   Tseng, Chih Yuan ^a   Gajewski, Melissa ^a   Winter, Philip ^a   Alisaraie, Laleh ^a   Patterson, Jordan ^a   Carpenter, Eric ^a   Wang, Weiwei ^a   Deyholos, Michael K ^a   Li, Linji ^c   Sun, Xiao ^c   Zhang, Yong ^c   Wong, Gane Ka Shu ^a,c  

^a UNIVERSITY OF ALBERTA   (Canada)

^b FAYOUM UNIVERSITY   (Egypt)

^c BGI SHENZHEN   (China)

^d CROSS CANCER INSTITUTE   (Canada)

Author keywords

chemotherapy; nanopores; paclitaxel; tubulin; yew tree

Indexed keywords

MESSENGER RNA; PACLITAXEL; TUBULIN;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; COMPUTER PROGRAM; CONTROLLED STUDY; DRUG BINDING SITE; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG RESISTANCE; GENETIC VARIABILITY; MICROTUBULE; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; NANOPORE; NUCLEOTIDE SEQUENCE; PHYLOGENY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STRUCTURE; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; TAXUS BACCATA; TAXUS CUSPIDATA;

AMINO ACID SEQUENCE; BINDING SITES; HUMANS; MICROTUBULES; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; PACLITAXEL; PHYLOGENY; SEQUENCE HOMOLOGY, AMINO ACID; TAXUS; THERMODYNAMICS; TREES; TUBULIN;

EID: 84867840952     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-012-0829-y     Document Type: Article

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