Humanization by guided selections

Methods in Molecular Biology

Volumn 907, Issue , 2012, Pages 247-257

  Kim, Sang Jick ^a   Hong, Hyo Jeong ^b  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^b Kangwon National University   (South Korea)

Author keywords

Antibody library; Chain shuffling; Guided selection; Human antibody; Panning; Phage display

Indexed keywords

EID: 84867824571     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-61779-974-7_14     Document Type: Article

References (14)

1. Morrison SL, Johnson MJ, Herzenberg LA, Oi VT (1984) Chimeric human antibody molecules: mouse antigen-binding domains with human constant region domains. Proc Natl Acad Sci U S A 81:6851-6855
2. Jones PT, Dear PH, Foote J, Neuberger MS, Winter G (1986) Replacing the complementarity-determining regions in a human antibody with those from a mouse. Nature 321:522-525
3. Winter G, Harris WJ (1993) Humanized antibodies. Immunol Today 14:243-246
4. Reichert JM (2001) Monoclonal antibodies in the clinic. Nat Biotechnol 19:819-822
5. Roguska MA, Pedersen JT, Keddy CA, Henry AH, Searle SJ, Lambert JM, Goldmacher VS, Blattler WA, Rees AR, Guild BC (1994) Humanization of murine monoclonal antibodies through variable domain resurfacing. Proc Natl Acad Sci U S A 91:969-973
6. Pendley C, Schantz A, Wagner C (2003) Immunogenicity of therapeutic monoclonal antibodies. Curr Opin Mol Ther 5:172-179
7. Jespers LS, Roberts A, Mahler SM, Winter G, Hoogenboom HR (1994) Guiding the selection of human antibodies from phage display repertoires to a single epitope of an antigen. Bio/technology 12:899-903
8. Figini M, Marks JD, Winter G, Grif fi ths AD (1994) In vitro assembly of repertoires of antibody chains on the surface of phage by renaturation. J Mol Biol 239:68-78
9. Figini M, Obici L, Mezzanzanica D, Grif fi ths A, Colnaghi MI, Winter G, Canevari S (1998) Panning phage antibody libraries on cells: isolation of human Fab fragments against ovarian carcinoma using guided selection. Cancer Res 58:991-996
10. Watzka H, P fi zenmaier K, Moosmayer D (1998) Guided selection of antibody fragments speci fi c for human interferon gamma receptor 1 from a human VH-and VL-gene repertoire. Immunotechnology 3:279-291
11. Beiboer SH, Reurs A, Roovers RC, Arends JW, Whitelegg NR, Rees AR, Hoogenboom HR (2000) Guided selection of a pan carcinoma speci fi c antibody reveals similar binding characteristics yet structural divergence between the original murine antibody and its human equivalent. J Mol Biol 296:833-849
12. Schmidt A, Muller D, Mersmann M, Wuest T, Gerlach E, Garin-Chesa P, Rettig WJ, P fi zenmaier K, Moosmayer D (2001) Generation of human high-af fi nity antibodies speci fi c for the fi broblast activation protein by guided selection. Eur J Biochem/FEBS 268:1730-1738
13. Zhang Q, Zhang SH, Su MQ, Bao GQ, Liu JY, Yi J, Shen JJ, Hao XK (2007) Guided selection of an anti-gamma-seminoprotein human Fab for antibody directed enzyme prodrug therapy of prostate cancer. Cancer Immunol Immunother 56:477-489
14. Wang Z, Wang Y, Li Z, Li J, Dong Z (2000) Humanization of a mouse monoclonal antibody neutralizing TNF-alpha by guided selection. J Immunol Methods 241:171-184