Determinants of the essential one-carbon metabolism metabolites, homocysteine, S-adenosylmethionine, S-adenosylhomocysteine and folate, in cerebrospinal fluid

Clinical Chemistry and Laboratory Medicine

Volumn 50, Issue 9, 2012, Pages 1641-1647

  Smith, Desirée E C ^a   Smulders, Yvo M ^b,c   Blom, Henk J ^a,c   Popp, Julius ^d,e   Jessen, Frank ^d   Semmler, Alexander ^f   Farkas, Melinda ^f   Linnebank, Michael ^f  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^d UNIVERSITY HOSPITAL BONN   (Germany)

^e LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^f UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

Cerebrospinal fluid; Folate; Homocysteine; S adenosylhomocysteine; S adenosylmethionine

Indexed keywords

5 METHYLTETRAHYDROFOLIC ACID; FOLIC ACID; HOMOCYSTEINE; S ADENOSYLHOMOCYSTEINE; S ADENOSYLMETHIONINE;

ADULT; AGING; ARTICLE; CARBON METABOLISM; CEREBROSPINAL FLUID ANALYSIS; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; FLUORESCENCE ANALYSIS; HUMAN; LIQUID CHROMATOGRAPHY; MAJOR CLINICAL STUDY; MALE; MASS SPECTROMETRY; MENTAL DISEASE; METABOLITE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN CEREBROSPINAL FLUID LEVEL; VITAMIN BLOOD LEVEL;

EID: 84867795438     PISSN: 14346621     EISSN: 14374331     Source Type: Journal    
DOI: 10.1515/cclm-2012-0056     Document Type: Article

References (31)

1. Griffiths R, Tudball N. Observations on the fate of cystathionine in rat brain. Life Sci 1976;19:1217-24.
2. James SJ, Melnyk S, Pogribna M, Pogribny IP, Caudill MA. Elevation in S-adenosylhomocysteine and DNA hypomethyla-tion: potential epigenetic mechanism for homocysteine-related pathology. J Nutr 2002;132:2361S-6S.
3. Homocysteine Studies Collaboration. Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis. J Am Med Assoc 2002;288:2015-22.
4. Obeid R, Herrmann W. Mechanisms of homocysteine neuro-toxicity in neurodegenerative diseases with special reference to dementia. FEBS Lett 2006;580:2994-3005.
5. Stanger O, Fowler B, Piertzik K, Huemer M, Haschke-Becher E, Semmler A, et al. Homocysteine, folate and vitamin B12 in neu-ropsychiatric diseases: review and treatment recommendations. Expert Rev Neurother 2009;9:1393-412.
6. Isobe C, Murata T, Sato C, Terayama Y. Increase of total homo-cysteine concentration in cerebrospinal fluid in patients with Alzheimer's disease and Parkinson's disease. Life Sci 2005;77:1836-43.
7. Selley ML, Close DR, Stern SE. The effect of increased concentrations of homocysteine on the concentration of (E)-4-hydroxy-2-nonenal in the plasma and cerebrospinal fluid of patients with Alzheimer's disease. Neurobiol Aging 2002;23:383-8.
8. Finkelstein JD. Metabolic regulatory properties of S-adenosyl-methionine and S-adenosylhomocysteine. Clin Chem Lab Med 2007;45:1694-9.
9. Obeid R, Kostopoulos P, Knapp JP, Kasoha M, Becker G, Fassbender K, et al. Biomarkers of folate and vitamin B12 are related in blood and cerebrospinal fluid. Clin Chem 2007;53:326-33.
10. Bottiglieri T, Godfrey P, Flynn T, Carney MW, Toone BK, Reynolds EH. Cerebrospinal fluid S-adenosylmethionine in depression and dementia: effects of treatment with parenteral and oral S-adenosylmethionine. J Neurol Neurosurg Psychiatry 1990;53:1096-8.
11. Popp J, Lewczuk P, Linnebank M, Cvetanovska G, Smulders Y, Kolsch H, et al. Homocysteine Metabolism and Cerebrospinal Fluid Markers for Alzheimer's Disease. J Alzheimers Dis 2009;18:819-28.
12. Selhub J. Folate, vitamin B12 and vitamin B6 and one carbon metabolism. J Nutr Health Aging 2002;6:39-42.
13. Serot JM, Barbé F, Arning E, Bottiglieri T, Franck P, Montagne P, et al. Homocysteine and methylmalonic acid concentrations in cerebrospinal fluid: relation with age and Alzheimer's disease. J Neurol Neurosurg Psychiatry 2005;76:1585-7.
14. Brattstrom L, Lindgren A, Israelsson B, Andersson A, Hultberg B. Homocysteine and cysteine: determinants of plasma levels in middle-aged and elderly subjects. J Intern Med 1994;236:633-41.
15. Surtees R, Leonard J, Austin S. Association of demyelination with deficiency of cerebrospinal-fluid S-adenosylmethionine in inborn errors of methyl-transfer pathway. Lancet 1991;338:1550-4.
16. Linhart HG, Troen A, Bell GW, Cantu E, Chao WH, Moran E, et al. Folate deficiency induces genomic uracil misincorporation and hypomethylation but does not increase DNA point mutations. Gastroenterology 2009;136:227-35.
17. Serot JM, Christmann D, Dubost T, Bene MC, Faure GC. CSF-folate levels are decreased in late-onset AD patients. J Neural Transm 2001;108:93-9.
18. Hagnelius NO, Wahlund LO, Nilsson TK. CSF/serum folate gradient: physiology and determinants with special reference to dementia. Dement Geriatr Cogn Disord 2008;25:516-23.
19. Taylor MJ, Carney SM, Goodwin GM, Geddes JR. Folate for depressive disorders: systematic review and meta-analysis of randomized controlled trials. J Psychopharmacol 2004;18:251-6.
20. Smach MA, Jacob N, Golmard JL, Charfeddine B, Lammouchi T, Ben OL, et al. Folate and homocysteine in the cerebrospinal fluid of patients with Alzheimer's disease or dementia: a case control study. Eur Neurol 2011;65:270-8.
21. Ramaekers VT, Blau N. Cerebral folate deficiency. Dev Med Child Neurol 2004;46:843-51.
22. Folstein MF, Robins LN, Helzer JE. The mini-mental state examination. Arch Gen Psychiatry 1983;40:812.
23. Struys EA, Jansen EE, de Meer K, Jakobs C. Determination of S-adenosylmethionine and S-adenosylhomocysteine in plasma and cerebrospinal fluid by stable-isotope dilution tandem mass spectrometry. Clin Chem 2000;46:1650-6.
24. Smith DE, Kok RM, Teerlink T, Jakobs C, Smulders YM. Quantitative determination of erythrocyte folate vitamer distribution by liquid chromatography-tandem mass spectrometry. Clin Chem Lab Med 2006;44:450-9.
25. Ubbink JB, Hayward Vermaak WJ, Bissbort S. Rapid high-performance liquid chromatographic assay for total homo-cysteine levels in human serum. J Chromatogr 1991;565:441-6.
26. Smulders YM, Smith DE, Kok RM, Teerlink T, Gellekink H, Vaes WH, et al. Red blood cell folate vitamer distribution in healthy subjects is determined by the methylenetetrahydrofolate reductase C677T polymorphism and by the total folate status. J Nutr Biochem 2007;18:693-9.
27. Fazili Z, Pfeiffer CM, Zhang M. Comparison of serum folate species analyzed by LC-MS/MS with total folate measured by microbiologic assay and Bio-Rad radioassay. Clin Chem 2007;53:781-4.
28. Weir DG, Molloy AM, Keating JN, Young PB, Kennedy S, Kennedy DG, et al. Correlation of the ratio of S-adenosyl-L-methionine to S-adenosyl-L-homocysteine in the brain and cerebrospinal fluid of the pig: implications for the determination of this methylation ratio in human brain. Clin Sci (Lond) 1992;82:93-7.
29. Morrison LD, Smith DD, Kish SJ. Brain S-adenosylmethionine levels are severely decreased in Alzheimer's disease. J Neurochem 1996;67:1328-31.
30. Wollack JB, Makori B, Ahlawat S, Koneru R, Picinich SC, Smith A, et al. Characterization of folate uptake by choroid plexus epithelial cells in a rat primary culture model. J Neurochem 2008;104:1494-503.
31. Steinfeld R, Grapp M, Kraetzner R, Dreha-Kulaczewski S, Helms G, Dechent P, et al. Folate receptor alpha defect causes cerebral folate transport deficiency: a treatable neurodegenera-tive disorder associated with disturbed myelin metabolism. Am J Hum Genet 2009;85:354-63.