Effects of ranitidine on quality of gastric ulcer healing compared with famotidine: A randomized, controlled, multicenter trial

International Journal of Clinical Pharmacology Research

Volumn 25, Issue 4, 2005, Pages 187-194

  Higuchi, K ^a   Watanabe, T ^b   Tominaga, K ^a   Shiba, M ^a   Nakagawa, K ^b   Uno, H ^c   Kitada, K ^d   Satoh, H ^e   Chono, S ^f   Uchida, T ^a   Fujiwara, Y ^a   Arakawa, T ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b Higashisumiyoshi Morimoto Hospital   (Japan)

^c Oono Memorial Hospital   (Japan)

^d Aioi Hospital   (Japan)

^e Fujiidera City Hospital   (Japan)

^f Machida Gastrointestinal Hospital   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

FAMOTIDINE; RANITIDINE;

ADULT; AGED; ARTICLE; CELL INFILTRATION; CLINICAL PROTOCOL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; FEMALE; GASTROSCOPY; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MONONUCLEAR CELL; MULTICENTER STUDY; NEUTROPHIL CHEMOTAXIS; QUALITY CONTROL; RANDOMIZED CONTROLLED TRIAL; SCAR FORMATION; SCORING SYSTEM; STATISTICAL SIGNIFICANCE; STOMACH ANTRUM; STOMACH MUCOSA; STOMACH ULCER; ULCER HEALING;

ADULT; AGED; AGED, 80 AND OVER; ANTI-ULCER AGENTS; FAMOTIDINE; FEMALE; GASTRIC MUCOSA; GASTROSCOPY; HISTAMINE H2 ANTAGONISTS; HUMANS; LEUKOCYTE COUNT; MALE; MIDDLE AGED; RANITIDINE; STOMACH ULCER; WOUND HEALING;

EID: 29144461695     PISSN: 02511649     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. NIH Consensus Development Panel on Helicobacter pylori in peptic ulcer disease. Helicobacter pylori in peptic ulcer disease. JAMA, 272, 65, 1994.
2. Current European concepts in the management of Helicobacter pylori infection: The Maastricht consensus reports. Gut, 41, 8, 1997.
3. O'Keefe S.J.D., Spitaels J.M., Mannion G., et al. Misoprostol, a synthetic prostaglandin E analogue, in the treatment of duodenal ulcers: A double-blind, cimetidine-controlled trial. S. Afr. Med J., 67, 321, 1985.
4. Arakawa T., Nebiki H., Uchida T., et al. Clinical assessment of quality of ulcer healing: A new endoscopic approach. Eur. J. Gastroenterol Hepatol., 5(Suppl. 3), S87, 1993.
5. Arakawa T., Kobayashi K. Quality of ulcer healing: A new concept to rank healed peptic ulcers. Gastroenterol. Jpn., 28(Suppl. 5), 158, 1993.
6. Tarnawski A., Stachura J., Douglass T.G., et al. Indomethacin impairs quality of experimental gastric ulcer healing: A quality histologic and ultrastructural analysis. In: Gardner A., O'Brian P.E. (Eds.). "Mechanisms of Injury, Protection and Repair of the Upper Gastrointestinal Tract." John Wiley & Sons, New York, 1991, pp. 521-31.
7. Arakawa T., Watanabe T., Fukuda T., et al. Rebamipide, novel prostaglandin-inducer, accelerates healing and reduces relapse of acetic acid-induced rat gastric ulcer. Comparison with cimetidine. Dig. Dis. Sci., 40(11), 2469, 1995.
8. Sakaki N., Takemoto T. The relationship between endoscopic findings of gastric ulcer scar and ulcer relapse. J. Clin. Gastroenterol., 17(Suppl. 1), S64, 1993.
9. Higuchi K., Arakawa T., Nebiki H., et al. Rebamipide, a unique gastroprotective drug, prevents recurrence of gastric ulcers without affecting Helicobacter pylori status. Dig. Dis. Sci., 43(Suppl. 9), S995, 1998.
10. Tarnawski A., Holander D., Krause W.J., et al. 'Healed' experimental gastric ulcers remain histologicaily and ultrastructurally abnormal. J. Clin. Gastroenterol., 12(Suppl. 1), S139, 1990.
11. Pan S., Liao C.H., Lien G.S., et al. Histological maturity of healed duodenal ulcers and ulcer recurrence after treatment with colloidal bismuth subcitrate or cimetidine. Gastroenterology, 101, 1187, 1991.
12. Nebiki H., Arakawa T., Higuchi K., et al. Quality of ulcer healing influences the relapse of gastric ulcers in humans. J. Gastroenterol. Hepatol., 12, 109, 1997.
13. Watanabe T., Higuchi K., Tanigawa T., et al. Mechanisms of peptic ulcer recurrence: Role of inflammation. Inflammopharmacology, 10, 291, 2002.
14. Watanabe T., Arakawa T., Fukuda T., et al. Role of neutrophils in a rat model of gastric ulcer recurrence caused by interleukin-1b. Am. J. Pathol., 150, 971, 1997.
15. Watanabe T., Higuchi K., Tominaga K., et al. Acid regulates inflammatory response in a rat model of induction of gastric ulcer recurrence by interleukin 1 beta. Gut, 48, 774, 2001.
16. Watanabe T, Higuchi K., Hamaguchi M., et al. Monocyte chemotactic protein-1 regulates leukocyte recruitment during gastric ulcer recurrence induced by tumor necrosis factor-alpha. Am. J. Physiol. Gastrointest. Liver Physiol., 287, G919, 2004.
17. 2-receptor antagonists in peptic ulcer disease. Drugs, 44, 709, 1992.
18. Konturek S.J., Radecki T., Brozozowski T., et al. Gastric cytoprotection by prostaglandins, ranitidine, and probabthine in rats. Scand. J. Gastroenterol., 16, 7, 1981.
19. Okajima K., Murakami K., Liu W., et al. Inhibition of neutrophil activation by ranitidine contributes to prevent stress-induced gastric mucosal injury in rats. Crit. Care Med., 28, 2858, 2000.
20. Higuchi K., Fujiwara Y., Tominaga T., et al. Is eradication sufficient to heal gastric ulcers in patients infected with Helicobacter pylori? A randomized, controlled, prospective study. Aliment. Pharmacol. Ther., 17, 111, 2003.
21. Dixon M.F., Genta R.M., Yardley J.H., et al. Classification and grading of gastritis. The updated Sydney System. International Workshop on the Histopathology of Gastritis, Houston 1994. Am. J. Surg. Pathol., 20, 1161, 1996.
22. Altman D.G. "Practical Statistics for Medical Research," Chapman and Hall, London, 1991.
23. Landis J.R., Koch G.G. The measurement of observer agreement for categorical data. Biometrics, 33, 159, 1977.
24. Arakawa T., Watanabe T., Fukuda T., et al. Indomethacin treatment during initial period of acetic acid-induced rat gastric ulcer healing promotes persistent polymorphonuclear cell-infiltration and increases future ulcer recurrence: Possible mediation of prostaglandins. Dig. Dis. Sci., 41, 2055, 1996.
25. Murakami K., Okajima K., Uchiba M., et al. Role of granulocyte elastase in indomethacin-induced gastric mucosal lesion formation in rats. J. Lab. Clin. Med., 130, 307, 1997.
26. Suzuki M., Asako H., Kubes P., et al. Neutrophil-derived oxidants promote leukocyte adherence in postcapillary venules. Microvasc. Res., 42, 125, 1991.
27. Zimmerman B.J., Granger D.N. Reperfusion-induced leukocyte infiltration: Role of elastase. Am. J. Physiol., 259, H390, 1990.
28. 2-receptor antagonists are scavengers of oxygen radicals. Eur. J. Clin. Invest., 24, 476, 1994.