The chondroitin polymerase K4CP and the molecular mechanism of selective bindings of donor substrates to two active sites

Journal of Biological Chemistry

Volumn 283, Issue 47, 2008, Pages 32328-32333

  Sobhany, Mack ^a   Kakuta, Yoshimitsu ^b   Sugiura, Nobuo ^c   Kimata, Koji ^c   Negishi, Masahiko ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b KYUSHU UNIVERSITY   (Japan)

^c AICHI MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; CHEMICAL REACTIONS; GLUCOSE; INTERNET PROTOCOLS; MOLECULES; MONOMERS; NUCLEIC ACIDS; ORGANIC ACIDS; POLYMERIZATION; POLYMERS; POLYSACCHARIDES; PORT TERMINALS; RNA; VOLUMETRIC ANALYSIS;

ACTIVE SITES; BINDING AFFINITIES; CATALYTIC MECHANISMS; CHONDROITIN POLYMERASES; DONOR MOLECULES; DONOR SUBSTRATES; GLUCORONIC ACIDS; HIGH AFFINITIES; ISOTHERMAL TITRATION CALORIMETRIES; MOLECULAR MECHANISMS; MULTI-FUNCTIONAL; POLYMERIZATION REACTIONS; SELECTIVE BINDINGS; SPECIFIC BINDINGS; TERMINAL FRAGMENTS; TERMINAL REGIONS; TRANSFER REACTIONS;

BINDING SITES;

BACTERIAL ENZYME; CHONDROITIN POLYMERASE; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE GLUCURONIC ACID; URIDINE DIPHOSPHATE N ACETYLGALACTOSAMINE;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING SITE; CARBOXY TERMINAL SEQUENCE; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME MECHANISM; ENZYME PURIFICATION; ENZYME SUBSTRATE; ISOTHERMAL TITRATION CALORIMETRY; MOLECULAR MECHANICS; MUTANT; POLYMERIZATION; PRIORITY JOURNAL; REGULATORY MECHANISM; SITE DIRECTED MUTAGENESIS;

CALORIMETRY; CATALYTIC DOMAIN; DISACCHARIDES; DNA; ESCHERICHIA COLI; HEXOSYLTRANSFERASES; HYDROLYSIS; KINETICS; MUTATION; PEPTIDES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; SUBSTRATE SPECIFICITY; THERMODYNAMICS;

BACTERIA (MICROORGANISMS);

EID: 57749098777     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M804332200     Document Type: Article

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