메뉴 건너뛰기




Volumn 26, Issue 16, 2012, Pages 2017-2026

The protease inhibitor atazanavir triggers autophagy and mitophagy in human preadipocytes

Author keywords

apoptosis; atazanavir; autophagy; HAART; ipodystrophy; mitophagy; oxidative stress

Indexed keywords

AMPRENAVIR; ATAZANAVIR; ENHANCED GREEN FLUORESCENT PROTEIN; LIPOCORTIN 5; OXYGEN; PROPIDIUM IODIDE; RITONAVIR; SUPEROXIDE;

EID: 84867745664     PISSN: 02699370     EISSN: 14735571     Source Type: Journal    
DOI: 10.1097/QAD.0b013e328359b8be     Document Type: Article
Times cited : (40)

References (40)
  • 1
    • 42149172274 scopus 로고    scopus 로고
    • Contribution of mitochondrial dysfunction and oxidative stress to cellular premature senescence induced by antiretroviral thymidine analogues
    • Caron M, Auclairt M, Vissian A, Vigouroux C, Capeau J. Contribution of mitochondrial dysfunction and oxidative stress to cellular premature senescence induced by antiretroviral thymidine analogues. Antivir Ther 2008; 13:27-38.
    • (2008) Antivir Ther , vol.13 , pp. 27-38
    • Caron, M.1    Auclairt, M.2    Vissian, A.3    Vigouroux, C.4    Capeau, J.5
  • 2
    • 18344367505 scopus 로고    scopus 로고
    • Changes in mitochondrial RNA production in cells treated with nucleoside analogues
    • Galluzzi L, Pinti M, Troiano L, Prada N, Nasi M, Ferraresi R, et al. Changes in mitochondrial RNA production in cells treated with nucleoside analogues. Antivir Ther 2005; 10:191-195.
    • (2005) Antivir Ther , vol.10 , pp. 191-195
    • Galluzzi, L.1    Pinti, M.2    Troiano, L.3    Prada, N.4    Nasi, M.5    Ferraresi, R.6
  • 3
    • 77949398882 scopus 로고    scopus 로고
    • Mitochondrial changes during d-drug-containing once-daily therapy in hiv-positive treatment-naive patients
    • Maggiolo F, Roat E, Pinti M, Nasi M, Gibellini L, De Biasi S, et al. Mitochondrial changes during D-drug-containing once-daily therapy in HIV-positive treatment-naive patients. Antivir Ther 2010; 15:51-59.
    • (2010) Antivir Ther , vol.15 , pp. 51-59
    • Maggiolo, F.1    Roat, E.2    Pinti, M.3    Nasi, M.4    Gibellini, L.5    De Biasi, S.6
  • 4
    • 79959485743 scopus 로고    scopus 로고
    • Decreased mitochondrial DNA content in subcutaneous fat from hiv-infected women taking antiretroviral therapy as measured at delivery
    • Nasi M, Pinti M, Chiesa E, Fiore S, Manzini S, Del Giovane C, et al. Decreased mitochondrial DNA content in subcutaneous fat from HIV-infected women taking antiretroviral therapy as measured at delivery. Antivir Ther 2011; 16:365-372.
    • (2011) Antivir Ther , vol.16 , pp. 365-372
    • Nasi, M.1    Pinti, M.2    Chiesa, E.3    Fiore, S.4    Manzini, S.5    Del Giovane, C.6
  • 5
    • 0037378552 scopus 로고    scopus 로고
    • Placenta and cord blood mitochondrial DNA toxicity in HIV-infected women receiving nucleoside reverse transcriptase inhibitors during pregnancy
    • Shiramizu B, Shikuma KM, Kamemoto L, Gerschenson M, Erdem G, Pinti M, et al. Placenta and cord blood mitochondrial DNA toxicity in HIV-infected women receiving nucleoside reverse transcriptase inhibitors during pregnancy. J Acquir Immune Defic Syndr 2003; 32:370-374.
    • (2003) J Acquir Immune Defic Syndr , vol.32 , pp. 370-374
    • Shiramizu, B.1    Shikuma, K.M.2    Kamemoto, L.3    Gerschenson, M.4    Erdem, G.5    Pinti, M.6
  • 6
    • 12544256168 scopus 로고    scopus 로고
    • Human immunodeficiency virus protease inhibitors accumulate into cultured human adipocytes and alter expression of adipocytokines
    • Vernochet C, Azoulay S, Duval D, Guedj R, Cottrez F, Vidal H, et al. Human immunodeficiency virus protease inhibitors accumulate into cultured human adipocytes and alter expression of adipocytokines. J Biol Chem 2005; 280:2238-2243.
    • (2005) J Biol Chem , vol.280 , pp. 2238-2243
    • Vernochet, C.1    Azoulay, S.2    Duval, D.3    Guedj, R.4    Cottrez, F.5    Vidal, H.6
  • 7
    • 0034007726 scopus 로고    scopus 로고
    • HIV protease inhibitors block human preadipocyte differentiation, but not via the PPAR-gamma/RXR heterodimer
    • Wentworth JM, Burris TP, Chatterjee VK. HIV protease inhibitors block human preadipocyte differentiation, but not via the PPAR-gamma/RXR heterodimer. J Endocrinol 2000; 164:R7-R10.
    • (2000) J Endocrinol , vol.164
    • Wentworth, J.M.1    Burris, T.P.2    Chatterjee, V.K.3
  • 8
    • 49849095230 scopus 로고    scopus 로고
    • Effect of atazanavir and ritonavir on the differentiation and adipokine secretion of human subcutaneous and omental preadipocytes
    • Jones SP, Waitt C, Sutton R, Back DJ, Pirmohamed M. Effect of atazanavir and ritonavir on the differentiation and adipokine secretion of human subcutaneous and omental preadipocytes. AIDS 2008; 22:1293-1298.
    • (2008) AIDS , vol.22 , pp. 1293-1298
    • Jones, S.P.1    Waitt, C.2    Sutton, R.3    Back, D.J.4    Pirmohamed, M.5
  • 9
    • 84861659153 scopus 로고    scopus 로고
    • Effects of ritonavir-boosted darunavir atazanavir and lopinavir on adipose functions and insulin sensitivity in murine and human adipocytes
    • Capel E, Auclair M, Caron-Debarle M, Capeau J. Effects of ritonavir-boosted darunavir, atazanavir and lopinavir on adipose functions and insulin sensitivity in murine and human adipocytes. Antivir Ther 2012; 17:549-556.
    • (2012) Antivir Ther , vol.17 , pp. 549-556
    • Capel, E.1    Auclair, M.2    Caron-Debarle, M.3    Capeau, J.4
  • 10
    • 77951299062 scopus 로고    scopus 로고
    • Effect of ritonavir and atazanavir on human subcutaneous preadipocyte proliferation and differentiation
    • Caso G, Mileva I, McNurlan MA, Mynarcik DC, Darras F, Gelato MC. Effect of ritonavir and atazanavir on human subcutaneous preadipocyte proliferation and differentiation. Antiviral Res 2010; 86:137-143.
    • (2010) Antiviral Res , vol.86 , pp. 137-143
    • Caso, G.1    Mileva, I.2    McNurlan, M.A.3    Mynarcik, D.C.4    Darras, F.5    Gelato, M.C.6
  • 12
    • 34848886914 scopus 로고    scopus 로고
    • Autophagosome formation: Core machinery and adaptations
    • Xie Z, Klionsky DJ. Autophagosome formation: core machinery and adaptations. Nat Cell Biol 2007; 9:1102-1109.
    • (2007) Nat Cell Biol , vol.9 , pp. 1102-1109
    • Xie, Z.1    Klionsky, D.J.2
  • 13
    • 33846252817 scopus 로고    scopus 로고
    • Different fates of mitochondria: Alternative ways for degradation?
    • Mijaljica D, Prescott M, Devenish RJ. Different fates of mitochondria: alternative ways for degradation? Autophagy 2007; 3:4-9.
    • (2007) Autophagy , vol.3 , pp. 4-9
    • Mijaljica, D.1    Prescott, M.2    Devenish, R.J.3
  • 14
    • 34250898919 scopus 로고    scopus 로고
    • Mdm38 protein depletion causes loss of mitochondrial KR/HR exchange activity, osmotic swelling and mitophagy
    • Nowikovsky K, Reipert S, Devenish RJ, Schweyen RJ. Mdm38 protein depletion causes loss of mitochondrial KR/HR exchange activity, osmotic swelling and mitophagy. Cell Death Differ 2007; 14:1647-1656.
    • (2007) Cell Death Differ , vol.14 , pp. 1647-1656
    • Nowikovsky, K.1    Reipert, S.2    Devenish, R.J.3    Schweyen, R.J.4
  • 15
    • 33749080321 scopus 로고    scopus 로고
    • Autophagy in organelle homeostasis: Peroxisome turnover
    • Monastyrska I, Klionsky DJ. Autophagy in organelle homeostasis: peroxisome turnover. Mol Aspects Med 2006; 27:483-494.
    • (2006) Mol Aspects Med , vol.27 , pp. 483-494
    • Monastyrska, I.1    Klionsky, D.J.2
  • 16
    • 34248581851 scopus 로고    scopus 로고
    • ER-phagy: Selective autophagy of the endoplasmic reticulum
    • Bernales S, Schuck S, Walter P. ER-phagy: selective autophagy of the endoplasmic reticulum. Autophagy 2007; 3:285-287.
    • (2007) Autophagy , vol.3 , pp. 285-287
    • Bernales, S.1    Schuck, S.2    Walter, P.3
  • 17
    • 16844366524 scopus 로고    scopus 로고
    • Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging
    • Lemasters JJ. Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging. Rejuvenation Res 2005; 8:3-5.
    • (2005) Rejuvenation Res , vol.8 , pp. 3-5
    • Lemasters, J.J.1
  • 18
    • 79952319773 scopus 로고    scopus 로고
    • Mitochondria removal by autophagy
    • Wang K, Klionsky DJ. Mitochondria removal by autophagy. Autophagy 2011; 7:297-300.
    • (2011) Autophagy , vol.7 , pp. 297-300
    • Wang, K.1    Klionsky, D.J.2
  • 19
    • 43449121547 scopus 로고    scopus 로고
    • Senescence, apoptosis or autophagy? When a damaged cell must decide its path: A mini-review
    • Vicencio JM, Galluzzi L, Tajeddine N, Ortiz C, Criollo A, Tasdemir E, et al. Senescence, apoptosis or autophagy? When a damaged cell must decide its path: a mini-review. Gerontology 2008; 54:92-99.
    • (2008) Gerontology , vol.54 , pp. 92-99
    • Vicencio, J.M.1    Galluzzi, L.2    Tajeddine, N.3    Ortiz, C.4    Criollo, A.5    Tasdemir, E.6
  • 20
    • 77953493175 scopus 로고    scopus 로고
    • Atg7 deficiency increases resistance of MCF-7 human breast cancer cells to photody-namic therapy
    • Xue LY, Chiu SM, Oleinick NL. Atg7 deficiency increases resistance of MCF-7 human breast cancer cells to photody-namic therapy. Autophagy 2010; 6:248-255.
    • (2010) Autophagy , vol.6 , pp. 248-255
    • Xue, L.Y.1    Chiu, S.M.2    Oleinick, N.L.3
  • 22
    • 69949106925 scopus 로고    scopus 로고
    • The double-edged sword of autophagy modulation in cancer
    • White E, DiPaola RS. The double-edged sword of autophagy modulation in cancer. Clin Cancer Res 2009; 15:5308-5316.
    • (2009) Clin Cancer Res , vol.15 , pp. 5308-5316
    • White, E.1    Dipaola, R.S.2
  • 23
    • 80052028765 scopus 로고    scopus 로고
    • Compromising mitochondrial function with the antiretroviral drug efavirenz induces cell survival-promoting autophagy
    • Apostolova N, Gomez-Sucerquia LJ, Gortat A, Blas-Garcia A, Esplugues JV. Compromising mitochondrial function with the antiretroviral drug efavirenz induces cell survival-promoting autophagy. Hepatology 2011; 54:1009-1019.
    • (2011) Hepatology , vol.54 , pp. 1009-1019
    • Apostolova, N.1    Gomez-Sucerquia, L.J.2    Gortat, A.3    Blas-Garcia, A.4    Esplugues, J.V.5
  • 24
    • 34548827350 scopus 로고    scopus 로고
    • Nelfinavir, A lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy, and apoptosis in vitro and in vivo
    • Gills JJ, Lopiccolo J, Tsurutani J, Shoemaker RH, Best CJ, Abu-Asab MS, et al. Nelfinavir, A lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy, and apoptosis in vitro and in vivo. Clin Cancer Res 2007; 13:5183-5194.
    • (2007) Clin Cancer Res , vol.13 , pp. 5183-5194
    • Gills, J.J.1    Lopiccolo, J.2    Tsurutani, J.3    Shoemaker, R.H.4    Best, C.J.5    Abu-Asab, M.S.6
  • 25
    • 3142757512 scopus 로고    scopus 로고
    • Multifluorescence labeling and colocalization analyses
    • Riccio M, Dembic M, Cinti C, Santi S. Multifluorescence labeling and colocalization analyses. Methods Mol Biol 2004; 285:171-177.
    • (2004) Methods Mol Biol , vol.285 , pp. 171-177
    • Riccio, M.1    Dembic, M.2    Cinti, C.3    Santi, S.4
  • 26
    • 38349158077 scopus 로고    scopus 로고
    • Simultaneous detection of apoptosis and mitochon-drial superoxide production in live cells by flow cytometry and confocal microscopy
    • Mukhopadhyay P, Rajesh M, Hasko G, Hawkins BJ, Madesh M, Pacher P. Simultaneous detection of apoptosis and mitochon-drial superoxide production in live cells by flow cytometry and confocal microscopy. Nat Protoc 2007; 2:2295-2301.
    • (2007) Nat Protoc , vol.2 , pp. 2295-2301
    • Mukhopadhyay, P.1    Rajesh, M.2    Hasko, G.3    Hawkins, B.J.4    Madesh, M.5    Pacher, P.6
  • 27
    • 39149116749 scopus 로고    scopus 로고
    • Multiparametric analysis of cells with different mitochondrial membrane potential during apoptosis by polychromatic flow cytometry
    • Troiano L, Ferraresi R, Lugli E, Nemes E, Roat E, Nasi M, et al. Multiparametric analysis of cells with different mitochondrial membrane potential during apoptosis by polychromatic flow cytometry. Nat Protoc 2007; 2:2719-2727.
    • (2007) Nat Protoc , vol.2 , pp. 2719-2727
    • Troiano, L.1    Ferraresi, R.2    Lugli, E.3    Nemes, E.4    Roat, E.5    Nasi, M.6
  • 28
    • 74949112458 scopus 로고    scopus 로고
    • Simultaneous analysis of reactive oxygen species and reduced glutathione content in living cells by polychromatic flow cytometry
    • Cossarizza A, Ferraresi R, Troiano L, Roat E, Gibellini L, Ber-toncelli L, et al. Simultaneous analysis of reactive oxygen species and reduced glutathione content in living cells by polychromatic flow cytometry. Nat Protoc 2009; 4:1790-1797.
    • (2009) Nat Protoc , vol.4 , pp. 1790-1797
    • Cossarizza, A.1    Ferraresi, R.2    Troiano, L.3    Roat, E.4    Gibellini, L.5    Ber-Toncelli, L.6
  • 29
    • 2342441342 scopus 로고    scopus 로고
    • Adipocytes targets and actors in the pathogenesis of HIV-associated lipodystrophy and metabolic alterations
    • Gougeon ML, Penicaud L, Fromenty B, Leclercq P, Viard JP, Capeau J. Adipocytes targets and actors in the pathogenesis of HIV-associated lipodystrophy and metabolic alterations. Anti-vir Ther 2004; 9:161-177.
    • (2004) Anti-vir Ther , vol.9 , pp. 161-177
    • Gougeon, M.L.1    Penicaud, L.2    Fromenty, B.3    Leclercq, P.4    Viard, J.P.5    Capeau, J.6
  • 30
    • 11144268546 scopus 로고    scopus 로고
    • Antiretroviral drugs with adverse effects on adipocyte lipid metabolism and survival alter the expression and secretion of proinflammatory cytokines and adiponectin in vitro
    • Lagathu C, Bastard JP, Auclair M, Maachi M, Kornprobst M, Capeau J, et al. Antiretroviral drugs with adverse effects on adipocyte lipid metabolism and survival alter the expression and secretion of proinflammatory cytokines and adiponectin in vitro. Antivir Ther 2004; 9:911-920.
    • (2004) Antivir Ther , vol.9 , pp. 911-920
    • Lagathu, C.1    Bastard, J.P.2    Auclair, M.3    Maachi, M.4    Kornprobst, M.5    Capeau, J.6
  • 31
    • 0032805208 scopus 로고    scopus 로고
    • Characterization of a cholesterol response element (CRE) in the promoter of the cholesteryl ester transfer protein gene: Functional role of the transcription factors SREBP-1a,-2, and YY1
    • Gauthier B, Robb M, Gaudet F, Ginsburg GS, McPherson R. Characterization of a cholesterol response element (CRE) in the promoter of the cholesteryl ester transfer protein gene: functional role of the transcription factors SREBP-1a,-2, and YY1. J Lipid Res 1999; 40:1284-1293.
    • (1999) J Lipid Res , vol.40 , pp. 1284-1293
    • Gauthier, B.1    Robb, M.2    Gaudet, F.3    Ginsburg, G.S.4    McPherson, R.5
  • 32
    • 0035854792 scopus 로고    scopus 로고
    • Cholesteryl ester transfer protein biosynthesis and cellular cholesterol homeostasis are tightly interconnected
    • Izem L, Morton RE. Cholesteryl ester transfer protein biosynthesis and cellular cholesterol homeostasis are tightly interconnected. J Biol Chem 2001; 276:26534-26541.
    • (2001) J Biol Chem , vol.276 , pp. 26534-26541
    • Izem, L.1    Morton, R.E.2
  • 34
    • 77949556554 scopus 로고    scopus 로고
    • Upregulation of nuclear-encoded mitochondrial LON protease in haart-treated HIV-positive patients with lipody-strophy: Implications for the pathogenesis of the disease
    • Pinti M, Gibellini L, Guaraldi G, Orlando G, Gant TW, Morselli E, et al. Upregulation of nuclear-encoded mitochondrial LON protease in HAART-treated HIV-positive patients with lipody-strophy: implications for the pathogenesis of the disease. AIDS 2010; 24:841-850.
    • (2010) AIDS , vol.24 , pp. 841-850
    • Pinti, M.1    Gibellini, L.2    Guaraldi, G.3    Orlando, G.4    Gant, T.W.5    Morselli, E.6
  • 35
    • 0029952738 scopus 로고    scopus 로고
    • Human liposarcoma cell line, SW872, secretes cholesteryl ester transfer protein in response to cholesterol
    • Richardson MA, Berg DT, Johnston PA, McClure D, Grinnell BW. Human liposarcoma cell line, SW872, secretes cholesteryl ester transfer protein in response to cholesterol. J Lipid Res 1996; 37:1162-1166.
    • (1996) J Lipid Res , vol.37 , pp. 1162-1166
    • Richardson, M.A.1    Berg, D.T.2    Johnston, P.A.3    McClure, D.4    Grinnell, B.W.5
  • 36
    • 38549110110 scopus 로고    scopus 로고
    • Fission and selective fusion govern mitochon-drial segregation and elimination by autophagy
    • Twig G, Elorza A, Molina AJ, Mohamed H, Wikstrom JD, Walzer G, et al. Fission and selective fusion govern mitochon-drial segregation and elimination by autophagy. EMBO J 2008; 27:433-446.
    • (2008) EMBO J , vol.27 , pp. 433-446
    • Twig, G.1    Elorza, A.2    Molina, A.J.3    Mohamed, H.4    Wikstrom, J.D.5    Walzer, G.6
  • 37
    • 84861722850 scopus 로고    scopus 로고
    • Nicotinamide-induced mitophagy: Event mediated by NADR/NADH ratio and SIRT1 protein activation
    • Jang SY, Kang HT, Hwang ES. Nicotinamide-induced mitophagy: event mediated by NADR/NADH ratio and SIRT1 protein activation. J Biol Chem 2012; 287:19304-19314.
    • (2012) J Biol Chem , vol.287 , pp. 19304-19314
    • Jang, S.Y.1    Kang, H.T.2    Hwang, E.S.3
  • 38
    • 79955566601 scopus 로고    scopus 로고
    • Within-patient atazanavir trough concentration monitoring in HIV-1-infected patients
    • Crutchley RD, Ma Q, Sulaiman A, Hochreitter J, Morse GD. Within-patient atazanavir trough concentration monitoring in HIV-1-infected patients. J Pharm Pract 2011; 24:216-222.
    • (2011) J Pharm Pract , vol.24 , pp. 216-222
    • Crutchley, R.D.1    Ma, Q.2    Sulaiman, A.3    Hochreitter, J.4    Morse, G.D.5
  • 39
    • 77950344979 scopus 로고    scopus 로고
    • Dyslipidemia in HIV-infected individuals: From pharmacogenetics to pharmacogenomics
    • Tarr PE, Rotger M, Telenti A. Dyslipidemia in HIV-infected individuals: from pharmacogenetics to pharmacogenomics. Pharmacogenomics 2010; 11:587-594.
    • (2010) Pharmacogenomics , vol.11 , pp. 587-594
    • Tarr, P.E.1    Rotger, M.2    Telenti, A.3
  • 40
    • 26844526004 scopus 로고    scopus 로고
    • Genetic polymorphisms of Fas (CD95) and Fas ligand (CD178) influence the rise in CD4R T cell count after antiretroviral therapy in drug-näive HIV-positive patients
    • Nasi M, Pinti M, Bugarini R, Troiano L, Lugli E, Bellodi C, et al. Genetic polymorphisms of Fas (CD95) and Fas ligand (CD178) influence the rise in CD4R T cell count after antiretroviral therapy in drug-näive HIV-positive patients. Immunogenetics 2005; 57:628-635.
    • (2005) Immunogenetics , vol.57 , pp. 628-635
    • Nasi, M.1    Pinti, M.2    Bugarini, R.3    Troiano, L.4    Lugli, E.5    Bellodi, C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.