Highly sensitive and rapid ultra-performance liquid chromatography-tandem mass spectrometry method for the determination of nifedipine in human plasma and its application to a bioequivalence study

Biomedical Chromatography

Volumn 26, Issue 12, 2012, Pages 1509-1518

  Patel, Daxesh P ^a   Sharma, Primal ^a   Sanyal, Mallika ^b   Singhal, Puran ^c   Shrivastav, Pranav S ^a  

^a GUJARAT UNIVERSITY   (India)

^b ST XAVIER S COLLEGE   (India)

^c Veeda Clinical Research India   (India)

Author keywords

Bioequivalence study; High throughput; Nifedipine; Sensitive; UPLC MS MS

Indexed keywords

CARBOXYLIC ACIDS; COLUMN CHROMATOGRAPHY; DRUG PRODUCTS; EXTRACTION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PARTICLE SIZE; PHASE SEPARATION; PLASMA (HUMAN); PYRIDINE;

BIOEQUIVALENCE STUDY; HIGH-THROUGHPUT; HUMAN PLASMAS; INTERNAL STANDARDS; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY; NIFEDIPINE; SENSITIVE; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; UPLC-MS/MS;

POSITIVE IONS;

ACETONITRILE; AMMONIUM ACETATE; CALCIUM CHANNEL BLOCKING AGENT; NIFEDIPINE; NIFEDIPINE D6; UNCLASSIFIED DRUG;

AREA UNDER THE CURVE; ARTICLE; BIOEQUIVALENCE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG FORMULATION; DRUG HALF LIFE; DRUG QUALITY; HUMAN; HUMAN EXPERIMENT; MALE; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; PARTICLE SIZE; SINGLE DRUG DOSE; TABLET; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

EID: 84867736015     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.2725     Document Type: Article

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