Determination of nifedipine in human plasma by ultra performance liquid chromatography-tandem mass spectrometry and its application in a pharmacokinetic study

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 879, Issue 20, 2011, Pages 1827-1832

  Wang, Dan ^a   Jiang, Kun ^a   Yang, Shuyan ^a   Qin, Feng ^a   Lu, Xiumei ^a   Li, Famei ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Human plasma; Nifedipine; Pharmacokinetics; UPLC MS MS

Indexed keywords

ACQUITY; AMMONIUM ACETATE; CHROMATOGRAPHIC SEPARATIONS; CLINICAL PHARMACOKINETICS; CONCENTRATION RANGES; HIGH THROUGHPUT; HUMAN PLASMAS; INTERNAL STANDARDS; LINEAR CALIBRATION CURVE; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; LIQUID-LIQUID EXTRACTION; LOWER LIMIT OF QUANTIFICATIONS; MOBILE PHASE; MULTIPLE-REACTION MONITORING MODES; NIFEDIPINE; NITRENDIPINE; PHARMACOKINETIC STUDIES; RELATIVE ERRORS; RELATIVE STANDARD DEVIATIONS; RUNTIMES; SAMPLE PREPARATION; SUSTAINED-RELEASE TABLETS; TRIPLE QUADRUPOLE; UPLC-MS/MS;

ACETONITRILE; AMMONIUM COMPOUNDS; CARBOXYLIC ACIDS; DRUG PRODUCTS; ELECTROSPRAY IONIZATION; ETHERS; HEXANE; LIQUIDS; MASS SPECTROMETERS; MASS SPECTROMETRY; PHARMACOKINETICS; PLASMA (HUMAN); PLASMAS; PYRIDINE; SOLVENT EXTRACTION;

LIQUID CHROMATOGRAPHY;

ACETONITRILE; AMMONIUM ACETATE; ETHER; HEXANE; NIFEDIPINE; NITRENDIPINE;

ACCURACY; ARTICLE; CALIBRATION; CONTROLLED STUDY; ELECTROSPRAY; ERROR; FLOW RATE; HUMAN; LIMIT OF QUANTITATION; LIQUID LIQUID EXTRACTION; MALE; NORMAL HUMAN; PLASMA; PRIORITY JOURNAL; QUADRUPOLE MASS SPECTROMETRY; QUALITY CONTROL; STANDARD; SUSTAINED RELEASE FORMULATION; TABLET; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; VALIDATION PROCESS;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DELAYED-ACTION PREPARATIONS; DRUG STABILITY; HUMANS; LEAST-SQUARES ANALYSIS; MALE; NIFEDIPINE; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

EID: 79957833942     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2011.04.034     Document Type: Article

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