Promoter methylation of esophageal cancer-related gene 4 in gastric cancer tissue and its clinical significance

Hepato-Gastroenterology

Volumn 59, Issue 118, 2012, Pages 1696-1698

  Wang, Yu Bin ^a   Ba, Cai Feng ^a  

^a JINZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Esophageal cancer related gene 4; Gastric cancer; Methylation; Methylation specific PCR

Indexed keywords

ADULT; AGE DISTRIBUTION; AGED; ARTICLE; CANCER STAGING; CLINICAL ARTICLE; DNA METHYLATION; ESOPHAGEAL CANCER RELATED GENE 4; ESOPHAGUS CANCER; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LYMPH NODE METASTASIS; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; SEX DIFFERENCE; STOMACH CANCER;

ADULT; AGED; CASE-CONTROL STUDIES; CHI-SQUARE DISTRIBUTION; CHINA; DNA METHYLATION; FEMALE; HUMANS; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOPLASM PROTEINS; NEOPLASM STAGING; POLYMERASE CHAIN REACTION; PROGNOSIS; PROMOTER REGIONS, GENETIC; RISK ASSESSMENT; RISK FACTORS; STOMACH NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 84867734135     PISSN: 01726390     EISSN: None     Source Type: Journal    
DOI: 10.5754/hge12258     Document Type: Article

References (17)

1. Cheng Y, Zheng GR: Role of DNA methylation in genesis of gastric cancer. Pract Prevent Med 2011; 18:1164-1166.
2. Su T, Liu HL, Lu SX, et al.: Cloning and identification of cDNA fragments related to human esophageal cancer. Chinese J Oncol 1998; 20(4):254-257.
3. Yue CM, Deng DJ, Bi MX: Expression of ECRG4 a novel esophageal cancer-related gene downregulated by CpG island hypermethylation in human esophageal squamous cell carcinoma. World J Gastroenterol 2003; 9:1174-1178.
4. Götze S, Feldhaus V, Traska T, et al.: ECRG4 is a candidate tumor suppressor gene frequently hypermethylated in colorectal carcinoma and glioma. BMC Cancer 2009; 9:447-457.
5. Herman JG, Graff JR, Myohanen S, et al.: Methylation specific PCR: A novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci USA 1996; 93:9821-9826. (Pubitemid 26296693)
6. Jemal A, Siegel R, Xu J, et al.: Cancer statistics. CA Cancer J Clin 2010; 6:277-300.
7. Zhao P, Dai M, Chen W, et al.: Cancer trends in China. JPn J Clin Oncol 2010; 40:281-285.
8. Leung WK, Wu MS, Kakugawa Y, et al.: Screening for gastric cancer in Asia: current evidence and practice. Lancet Oncol 2008; 9:279-287. (Pubitemid 351722947)
9. American Cancer Society: Cancer Facts and Figures 2010. Atlanta, Ga: American Cancer Society 2010.
10. Krejs GJ: Gastric Cancer: Epidemiology and risk factors. Dig Dis 2010; 28:600-603.
11. Wu K, Nie Y, Guo C, et al.: Molecular basis of therapeutic approaches to gastric cancer. J Gastroenterol HePatol 2009; 24:37-41.
12. Fukuda M, Yokozaki H, Shiba M, et al.: Genetic and epigenetic markers to identify high risk patients for multiple early gastric cancers after treatment with endoscopic mucosal resection. J Clin Biochem Nutr 2007; 40:203-209. (Pubitemid 46984213)
13. Mori Y, Ishiguro H, Kuwabara Y, et al.: Expression of ECRG4 is an independent prognostic factor for poor survival in patients with esophageal squamous cell carcinoma. Oncol Rep 2007; 18:981-985.
14. Li LW, Yu XY, Yang Y, et al.: Expression of esophageal cancer related gene 4 (ECRG4) a novel tumor suppressor gene in esophageal cancer and its inhibitory effect on the tumor growth in vitro and in vivo. Int J Cancer 2009; 125:1505-1513.
15. Fei F, Shao Z: Expression and epigenetic silencing of ECRG4 gene in breast cancer. ASCO Annual Meeting 2009.
16. Vanaja DK, Ehrich M, Van den Boom D, et al.: Hypermethylation of genes for diagnosis and risk stratification of prostate cancer. Cancer Invest 2009; 27:549-560.
17. Li W, Liu X, Zhang B, et al.: Overexpression of candidate tumor suppressor ECRG4 inhibits glioma proliferation and invasion. J Exp Clin Cancer Res 2010; 29:1-7.