Administration of the cyclic peptide COR-1 in humans (phase i study): Ex vivo measurements of anti-β1-adrenergic receptor antibody neutralization and of immune parameters

European Journal of Heart Failure

Volumn 14, Issue 11, 2012, Pages 1230-1239

  Münch, Götz ^a   Boivin Jahns, Valerie ^b   Holthoff, Hans Peter ^a   Adler, Kristin ^a   Lappo, Mariola ^c   Truöl, Stephan ^c   Degen, Heidrun ^a   Steiger, Nina ^a   Lohse, Martin J ^b   Jahns, Roland ^b   Ungerer, Martin ^a  

^a Corimmun GmbH ^*  (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c ABX CRO GmbH   (Germany)

Author keywords

Autoimmune disease; Beta adrenergic receptor; Heart Failure

Indexed keywords

AUTOANTIBODY; BETA 1 ADRENERGIC RECEPTOR ANTIBODY; COR 1; COR 1 ANTIBODY; CYCLOPEPTIDE; HEART ANTIBODY; INTERLEUKIN 6; INTERLEUKIN 8; PLACEBO; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ACHILLES TENDON RUPTURE; ADULT; AREA UNDER THE CURVE; ARTICLE; BURNING MOUTH SYNDROME; CLINICAL ARTICLE; COLD SENSATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DOSE ESCALATION; DRUG EFFICACY; DRUG MEGADOSE; DRUG SAFETY; DRUG TOLERABILITY; EX VIVO STUDY; FLU LIKE SYNDROME; HUMAN; IMMUNOLOGICAL PARAMETERS; MALE; MAXIMUM PLASMA CONCENTRATION; NAUSEA; OUTCOME ASSESSMENT; PHASE 1 CLINICAL TRIAL; PLASMA CLEARANCE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SIDE EFFECT; SINGLE BLIND PROCEDURE; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADRENERGIC ANTAGONISTS; ADULT; ANALYSIS OF VARIANCE; ANIMALS; AREA UNDER CURVE; AUTOANTIBODIES; CYTOKINES; FEMALE; HEART FAILURE; HEMODYNAMICS; HUMANS; IMMUNE SYSTEM; MALE; PEPTIDES, CYCLIC; RATS; RECEPTORS, ADRENERGIC; SINGLE-BLIND METHOD;

EID: 84867716776     PISSN: 13889842     EISSN: 18790844     Source Type: Journal    
DOI: 10.1093/eurjhf/hfs118     Document Type: Article

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