Determination of gemifloxacin on dried blood spots by hydrophilic interaction liquid chromatography with fluorescence detector: Application to pharmacokinetics in rats

Biomedical Chromatography

Volumn 26, Issue 12, 2012, Pages 1534-1542

  Nageswara Rao, R ^a   Naidu, Ch Gangu ^a   Guru Prasad, K ^a   Padiya, Raju ^a   Agwane, Sachin B ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

Author keywords

Dried blood spots; Gemifloxacin; Hydrophilic interaction liquid chromatography; Pharmacokinetics; Rat plasma

Indexed keywords

BLOOD; CHROMATOGRAPHIC ANALYSIS; COLUMN CHROMATOGRAPHY; DESIGN OF EXPERIMENTS; FLUORESCENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHILICITY;

CHROMATOGRAPHIC METHODS; CHROMATOGRAPHIC SEPARATIONS; DRIED BLOOD SPOT; FLUORESCENCE DETECTOR; GEMIFLOXACIN; HYDROPHILIC INTERACTION LIQUID CHROMATOGRAPHIES; HYDROPHILICS; LIQUID INTERACTIONS; RAT PLASMA; REVERSED PHASE;

PHARMACOKINETICS;

ACETONITRILE; AMPHOLYTE; CIPROFLOXACIN; GEMIFLOXACIN;

ACCURACY; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRIED BLOOD SPOT TESTING; DRUG DETERMINATION; DRUG STRUCTURE; FLUORESCENCE; HYDROPHILIC INTERACTION CHROMATOGRAPHY; MALE; NONHUMAN; RAT; VALIDATION STUDY;

RATTUS;

EID: 84867702315     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.2728     Document Type: Article

References (20)

1. Al-Hadiya BMH, Khady AA and Mostafa GAE. Validated liquid chromatographic-fluorescence method for the quantitation of gemifloxacin in human plasma. Talanta 2010; 83: 110-116.
2. Ball P, Mandell L, Patou G, Dankner W and Tillotson G. A new respiratory fluoroquinolone, oral gemifloxacin: a safety profile in context. International Journal of Antimicrobial Agents 2004; 23: 421-429.
3. Blondeau JM and Tillotson G. Role of gemifloxacin in the management of community-acquired lower respiratory tract infections. International Journal of Antimicrobial Agents 2008; 31: 299-306.
4. Branch SK. Guidelines from the International Conference on Harmonisation (ICH). Journal of Pharmaceutical and Biomedical Analysis 2005; 38: 798-805.
5. Doyle E, Fowles SE, McDonnell DF, McCarthy R and White SA. Rapid determination of gemifloxacin in human plasma by high-performance liquid chromatography-tandem mass spectrometry. Journal of Chromatography B 2000; 746: 191-198.
6. ICH. Guideline Q2A, Text on Validation of Analytical Procedures. International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use, 1994. Available from: http://www.ich.org
7. ICH. Guidelines for Validation of Analytical Procedures: Methodology - Step 4. International Conference of Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use, 1996.
8. Kaiser M, Grunspan LD, Costa TD and Tasso L. Reversed phase liquid chromatography method with fluorescence detection of gemifloxacin in rat plasma and its application to the pharmacokinetic study. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences 2011; 879: 3639-3644.
9. Lopez H, Stepanik D, Vilches V, Scarano S, Sarachian B, Mikaelian G and Finlay J. Comparative in vitro activity of gemifloxacin against gram-positive and gram-negative clinical isolates in Argentina. Diagnostic Microbiology and Infectious Disease 2001; 40: 187-192.
10. McCalley DV. Evaluation of the properties of a superficially porous silica stationary phase in hydrophilic interaction chromatography. Journal of Chromatography. A 2008; 1193: 85-91.
11. Mitchell CR, Bao Y, Benz NJ and Zhang S. Comparison of the sensitivity of evaporative universal detectors and LC/MS in the HILIC and the reversed-phase HPLC modes. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences 2009; 877: 4133-4139.
12. Owens RC, Bhavnani SM and Ambrose PG. Assessment of pharmacokinetic-pharmacodynamic target attainment of gemifloxacin against Streptococcus pneumoniae. Diagnostic Microbiology and Infectious Disease 2005; 51: 45-49.
13. Prieto J, Aguilar L, Fuentes F, Gimenez MJ, Alou L, Dal-Re R, Sorgel F and Frias J. Influence of diminished susceptibility of Streptococcus pneumoniae to ciprofloxacin on the serum bactericidal activity of gemifloxacin and trovafloxacin after a single dose in healthy volunteers. International Journal of Antimicrobial Agents 2001; 18: 231-238.
14. Rote AR and Pingle SP. Reverse phase-HPLC and HPTLC methods for determination of gemifloxacin mesylate in human plasma. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences 2009; 877: 3719-3723.
15. Roy B, Das A, Bhaumik U, Sarkar AK, Bose A, Mukharjee J, Chakrabarty US, Das AK and Pal TK. Determination of gemifloxacin in different tissues of rat after oral dosing of gemifloxacin mesylate by LC-MS/MS and its application in drug tissue distribution study. Journal of Pharmaceutical and Biomedical Analysis 2010; 52: 216-226.
16. Saravolatz L, Manzor O, Pawlak J and Belian B. Antimicrobial activity and a comparison of published pharmacodynamics of gemifloxacin and eight fluoroquinolones against Streptococcus pneumoniae. International Journal of Antimicrobial Agents 2005; 26: 81-84.
17. Shou WZ and Weng ND. Simple means to alleviate sensitivity loss by trifluoroacetic acid (TFA) mobile phases in the hydrophilic interaction chromatography-electro, spray tandem mass spectrometric (HILIC-ESI/MS/MS) bioanalysis of basic compounds. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences 2005; 825: 186-192.
18. Tetaz T, Detzner S, Friedlein A, Molitor B and Mary J-L. Hydrophilic interaction chromatography of intact, soluble proteins. Journal of Chromatography. A 2011; 1218: 5892-5896.
19. Yanagida A, Murao H, Ohnishi-Kameyama M, Yamakawa Y, Shoji A, Tagashira M, Kanda T, Shindo H and Shibusawa Y. Retention behavior of oligomeric proanthocyanidins in hydrophilic interaction chromatography. Journal of Chromatography. A 2007; 1143: 153-161.
20. Yong G and Sheetal G. Retention and selectivity of stationary phases for hydrophilic interaction chromatography. Journal of Chromatography. A 2011; 1218: 5920-5938.