Is it time for hepcidin to join the diagnostic toolkit for iron deficiency?

Expert Review of Hematology

Volumn 5, Issue 2, 2012, Pages 153-155

  Pasricha, Sant Rayn ^a,b  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b Southern Health   (Australia)

Author keywords

anemia; anemia of chronic disease; diagnostic testing; hepcidin; inflammation; iron deficiency; rheumatoid arthritis

Indexed keywords

FERRITIN; HEMOGLOBIN; HEPCIDIN; TRANSFERRIN;

ALGORITHM; CHROMATOGRAPHY; DIAGNOSTIC TEST; DIAGNOSTIC VALUE; ERYTHROBLAST; HEMOGLOBIN BLOOD LEVEL; HUMAN; INFLAMMATION; IRON ABSORPTION; IRON DEFICIENCY; IRON DEFICIENCY ANEMIA; IRON INTAKE; IRON METABOLISM; IRON STORAGE; MASS SPECTROMETRY; PRIORITY JOURNAL; RETICULOCYTE; REVIEW; RHEUMATOID ARTHRITIS;

EID: 84867691689     PISSN: 17474086     EISSN: 17474094     Source Type: Journal    
DOI: 10.1586/ehm.12.2     Document Type: Review

References (20)

1. Ganz T, Olbina G, Girelli D, Nemeth E, Westerman M. Immunoassay for human serum hepcidin. Blood 112(10), 4292-4297 (2008).
2. Bansal SS, Halket JM, Bomford A et al. Quantitation of hepcidin in human urine by liquid chromatography-mass spectrometry. Anal. Biochem. 384(2), 245-253 (2009).
3. Bozzini C, Campostrini N, Trombini P et al. Measurement of urinary hepcidin levels by SELDI-TOF-MS in HFEhemochromatosis. Blood Cells Mol. Dis. 40(3), 347-352 (2008).
4. Grebenchtchikov N, Geurts-Moespot AJ, Kroot JJ et al. High-sensitive radioimmunoassay for human serum hepcidin. Br. J. Haematol. 146(3), 317-325 (2009).
5. Kemna E, Tjalsma H, Laarakkers C, Nemeth E, Willems H, Swinkels D. Novel urine hepcidin assay by mass spectrometry. Blood 106(9), 3268-3270 (2005).
6. Kobold U, Dulffer T, Dangl M et al. Quantification of hepcidin-25 in human serum by isotope dilution micro-HPLC-tandem mass spectrometry. Clin. Chem. 54(9), 1584-1586 (2008).
7. Pasricha SR, Mcquilten Z, Westerman M et al. Serum hepcidin as a diagnostic test of iron deficiency in premenopausal female blood donors. Haematologica 96(8), 1099-1105 (2011).
8. Haase-Fielitz A, Mertens PR, Plass M et al. Urine hepcidin has additive value in ruling out cardiopulmonary bypass-associated acute kidney injury: an observational cohort study. Crit. Care 15(4), R186 (2011).
9. Zaritsky J, Young B, Wang HJ et al. Hepcidin-a potential novel biomarker for iron status in chronic kidney disease. Clin. J. Am. Soc. Nephrol. 4(6), 1051-1056 (2009).
10. Pasricha SR, Flecknoe-Brown SC, Allen KJ et al. Diagnosis and management of iron deficiency anaemia: a clinical update. Med. J. Aust. 193(9), 525-532 (2010).
11. WHO/UNICEF/UNU. Iron Deficiency Anaemia: Assessment, Prevention, and Control. A Guide for Programme Managers. WHO, Geneva, Switzerland (2001).
12. Wish JB. Assessing iron status: beyond serum ferritin and transferrin saturation. Clin. J. Am. Soc. Nephrol. 1(Suppl. 1), S4-S8 (2006).
13. Beguin Y. Soluble transferrin receptor for the evaluation of erythropoiesis and iron status. Clin. Chim. Acta 329(1-2), 9-22 (2003).
14. Sasu BJ, Li H, Rose MJ, Arvedson TL, Doellgast G, Molineux G. Serum hepcidin but not prohepcidin may be an effective marker for anemia of inflammation (AI). Blood Cells Mol. Dis. 45(3), 238-245 (2010).
15. Thomas C, Kobold U, Balan S, Roeddiger R, Thomas L. Serum hepcidin-25 may replace the ferritin index in the Thomas plot in assessing iron status in anemic patients. Int. J. Lab. Hematol. 33(2), 187-193 (2011).
16. van Santen S, van Dongen-Lases EC, de Vegt F et al. Hepcidin and hemoglobin content parameters in the diagnosis of iron deficiency in rheumatoid arthritis patients with anemia. Arthritis Rheum. 63(12), 3672-3680 (2011).
17. Kroot JJ, Laarakkers CM, Geurts-Moespot AJ et al. Immunochemical and massspectrometry-based serum hepcidin assays for iron metabolism disorders. Clin. Chem. 56(10), 1570-1579 (2010).
18. Armitage AE, Eddowes LA, Gileadi U et al. Hepcidin regulation by innate immune and infectious stimuli. Blood 118(15), 4129-4139 (2011).
19. Nemeth E, Valore EV, Territo M, Schiller G, Lichtenstein A, Ganz T. Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood 101(7), 2461-2463 (2003).
20. Nemeth E, Tuttle MS, Powelson J et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 306(5704), 2090-2093 (2004).