Obesity-Susceptibility Loci and Their Influence on Adiposity-Related Traits in Transition from Adolescence to Adulthood - The HUNT Study

PLoS ONE

Volumn 7, Issue 10, 2012, Pages

  Cuypers, Koenraad Frans ^a   Loos, Ruth J F ^b,c   Kvaløy, Kirsti ^a   Kulle, Bettina ^d,e   Romundstad, Pål ^f   Holmen, Turid Lingaas ^a  

^a NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^b ADDENBROOKE S HOSPITAL   (United Kingdom)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^d AKERSHUS UNIVERSITY HOSPITAL   (Norway)

^e UNIVERSITY OF OSLO   (Norway)

^f NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENCE; ADOLESCENT; ADULT; ADULTHOOD; ANTHROPOMETRY; ARTICLE; BDNF GENE; BODY FAT; BODY MASS; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; FTO GENE; GENE; GENE LOCUS; GENETIC PREDISPOSITION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; GNPDA2 GENE; HUMAN; KCTD15 GENE; LIFESTYLE; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MC4R GENE; MTCH2 GENE; NEGR1 GENE; NORWAY; OBESITY; PHYSICAL ACTIVITY; QUESTIONNAIRE; SINGLE NUCLEOTIDE POLYMORPHISM; TFAP2B GENE; TMEM18 GENE; WAIST CIRCUMFERENCE;

ADIPOSE TISSUE; ADIPOSITY; ADOLESCENT; ADULT; ALLELES; BODY MASS INDEX; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENETIC LOCI; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; MOTOR ACTIVITY; NORWAY; OBESITY; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; QUESTIONNAIRES; WAIST CIRCUMFERENCE;

EID: 84867679616     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0046912     Document Type: Article

References (37)

1. Livingstone MB, (2001) Childhood obesity in Europe: a growing concern. Public Health Nutr 4: 109-116.
2. Hill J (2006) Understanding and addressing the epidemic of obesity: an energy balance perspective. Endocr Rev: 750-761.
3. Papas M, Alberg A, Ewing R, Helzlsouer K, Gary T, et al. (2007) The built environment and obesity. Epidemiol Rev 129-143.
4. Bell CG, Walley AJ, Froguel P, (2005) The genetics of human obesity. Nature Reviews Genetics 6: 221-234.
5. Hardy R, Wills AK, Wong A, Elks CE, Wareham NJ, et al. (2010) Life course variations in the associations between FTO and MC4R gene variants and body size. Hum Mol Genet 19: 545-552.
6. Mei H, Chen W, Srinivasan SR, Jiang F, Schork N,et al. FTO influences on longitudinal BMI over childhood and adulthood and modulation on relationship between birth weight and longitudinal BMI. Hum Genet 128: 589-596.
7. Sovio U, Mook-Kanamori DO, Warrington NM, Lawrence R, Briollais L, et al. (2011) Association between common variation at the FTO locus and changes in body mass index from infancy to late childhood: the complex nature of genetic association through growth and development. PLoS Genet 7: e1001307.
8. Singh AS, Mulder C, Twisk JW, van Mechelen W, Chinapaw MJ, (2008) Tracking of childhood overweight into adulthood: a systematic review of the literature. Obes Rev 9: 474-488.
9. Patton GC, Coffey C, Carlin JB, Sawyer SM, Williams J, et al. (2011) Overweight and obesity between adolescence and young adulthood: a 10-year prospective cohort study. J Adolesc Health 48: 275-280.
10. Coady SA, Jaquish CE, Fabsitz RR, Larson MG, Cupples LA, et al. (2002) Genetic variability of adult body mass index: a longitudinal assessment in framingham families. Obes Res 10: 675-681.
11. Ortega-Alonso A, Sipila S, Kujala UM, Kaprio J, Rantanen T, (2009) Genetic influences on change in BMI from middle to old age: a 29-year follow-up study of twin sisters. Behav Genet 39: 154-164.
12. Hjelmborg JB, Fagnani C, Silventoinen K, McGue M, Korkeila M, et al. (2008) Genetic influences on growth traits of BMI: a longitudinal study of adult twins. Obesity (Silver Spring) 16: 847-852.
13. Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, et al. (2010) Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet 42: 937-948.
14. Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, et al. (2007) A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316: 889-894.
15. Loos RJ, Lindgren CM, Li S, Wheeler E, Zhao JH, et al. (2008) Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet 40: 768-775.
16. Thorleifsson G, Walters GB, Gudbjartsson DF, Steinthorsdottir V, Sulem P, et al. (2009) Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat Genet 41: 18-24.
17. Willer CJ, Speliotes EK, Loos RJ, Li S, Lindgren CM, et al. (2009) Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet 41: 25-34.
18. Heard-Costa NL, Zillikens MC, Monda KL, Johansson A, Harris TB, et al. (2009) NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium. PLoS Genet 5: e1000539.
19. Lindgren CM, Heid IM, Randall JC, Lamina C, Steinthorsdottir V, et al. (2009) Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet 5: e1000508.
20. Zhao J, Bradfield JP, Li M, Wang K, Zhang H, et al. (2009) The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMI. Obesity (Silver Spring) 17: 2254-2257.
21. den Hoed M, Ekelund U, Brage S, Grontved A, Zhao JH,et al. Genetic susceptibility to obesity and related traits in childhood and adolescence: influence of loci identified by genome-wide association studies. Diabetes 59: 2980-2988.
22. Holmen J MK, Krüger Ø, (2003) The Nord-Trøndelag Health study 1995-97 (HUNT2). Objectives, contents, methods and participation. Norsk Epidemiologi 13: 19-32.
23. Krokstad S, Westin S, (2002) Health inequalities by socioeconomic status among men in the Nord-Trondelag Health Study, Norway. Scand J Public Health 30: 113-124.
24. Cole TJ, Bellizzi MC, Flegal KM, Dietz WH, (2000) Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ 320: 1240-1243.
25. Bratberg GH, Nilsen TI, Holmen TL, Vatten LJ, (2007) Early sexual maturation, central adiposity and subsequent overweight in late adolescence. a four-year follow-up of 1605 adolescent Norwegian boys and girls: the Young HUNT study. BMC Public Health 7: 54.
26. Rangul V, Holmen TL, Kurtze N, Cuypers K, Midthjell K, (2008) Reliability and validity of two frequently used self-administered physical activity questionnaires in adolescents. BMC Med Res Methodol 8: 47.
27. Kurtze N, Rangul V, Hustvedt BE, Flanders WD, (2007) Reliability and validity of self-reported physical activity in the Nord-Trondelag Health Study (HUNT 2). Eur J Epidemiol 22: 379-387.
28. Heid IM, Jackson AU, Randall JC, Winkler TW, Qi L,et al. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet 42: 949-960.
29. Janssens AC, Moonesinghe R, Yang Q, Steyerberg EW, van Duijn CM, et al. (2007) The impact of genotype frequencies on the clinical validity of genomic profiling for predicting common chronic diseases. Genet Med 9: 528-535.
30. Haworth CM, Plomin R, Carnell S, Wardle J, (2008) Childhood obesity: genetic and environmental overlap with normal-range BMI. Obesity (Silver Spring) 16: 1585-1590.
31. Li S, Zhao JH, Luan J, Ekelund U, Luben RN, et al. (2010) Physical activity attenuates the genetic predisposition to obesity in 20,000 men and women from EPIC-Norfolk prospective population study. PLoS Med 7.
32. Haworth CM, Carnell S, Meaburn EL, Davis OS, Plomin R, et al. (2008) Increasing heritability of BMI and stronger associations with the FTO gene over childhood. Obesity (Silver Spring) 16: 2663-2668.
33. Ruiz JR, Labayen I, Ortega FB, Legry V, Moreno LA,et al. Attenuation of the effect of the FTO rs9939609 polymorphism on total and central body fat by physical activity in adolescents: the HELENA study. Arch Pediatr Adolesc Med 164: 328-333.
34. Kilpelainen TO, Qi L, Brage S, Sharp SJ, Sonestedt E, et al. (2011) Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children. PLoS Med 8: e1001116.
35. Li S, Zhao JH, Luan J, Luben RN, Rodwell SA,et al. Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies. Am J Clin Nutr 91: 184-190.
36. Page GP, George V, Go RC, Page PZ, Allison DB, (2003) "Are we there yet?": Deciding when one has demonstrated specific genetic causation in complex diseases and quantitative traits. Am J Hum Genet 73: 711-719.
37. Goris A, Maranian M, Walton A, Yeo TW, Ban M, et al. (2006) No evidence for association of a European-specific chromosome 17 inversion with multiple sclerosis. Eur J Hum Genet 14: 1064.