Improved eIF4E Binding Peptides by Phage Display Guided Design: Plasticity of Interacting Surfaces Yield Collective Effects

PLoS ONE

Volumn 7, Issue 10, 2012, Pages

  Zhou, Weizhuang ^a   Quah, Soo T ^b   Verma, Chandra S ^a,c,d   Liu, Yun ^a   Lane, David P ^b   Brown, Christopher J ^b  

^a BIOINFORMATICS INSTITUTE   (Singapore)

^b AGENCY FOR SCIENCE   (Singapore)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^d NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARAGINE; CYSTEINE; GLUTAMINE; HISTIDINE; INITIATION FACTOR 4E; INITIATION FACTOR 4G; THREONINE;

ALPHA HELIX; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HYDROGEN BOND; HYDROPHOBICITY; PHAGE DISPLAY; PLASTICITY; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN MODIFICATION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; STRUCTURE ACTIVITY RELATION; SURFACE PLASMON RESONANCE; THERMOSTABILITY;

AMINO ACID SEQUENCE; AMINO ACIDS; BINDING SITES; DRUG DESIGN; EUKARYOTIC INITIATION FACTOR-4E; HUMANS; KINETICS; MOLECULAR DOCKING SIMULATION; MOLECULAR SEQUENCE DATA; MUTATION; PEPTIDE LIBRARY; PEPTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS;

EID: 84867669239     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0047235     Document Type: Article

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