Repeated administration of Korea red ginseng extract increases non-rapid eye movement sleep via GABA A ergic systems

Journal of Ginseng Research

Volumn 36, Issue 4, 2012, Pages 403-410

  Lee, Chung Il ^a   Kim, Chung Soo ^a   Han, Jin Yi ^a   Oh, Eun Hye ^b   Oh, Ki Wan ^a   Eun, Jae Soon ^c  

^a Chungbuk National University   (South Korea)

^b Chungbuk National University College of Medicine   (South Korea)

^c Woosuk University   (South Korea)

Author keywords

Electroencephalogram; Non rapid eye movement; Panax ginseng; Power density; Rapid eye movement

Indexed keywords

EID: 84867667882     PISSN: 12268453     EISSN: None     Source Type: Journal    
DOI: 10.5142/jgr.2012.36.4.403     Document Type: Article

References (29)

1. Datta S, Maclean RR. Neurobiological mechanisms for the regulation of mammalian sleep-wake behavior: reinterpretation of historical evidence and inclusion of contemporary cellular and molecular evidence. Neurosci Biobehav Rev 2007;31:775-824.
2. Datta S, Hobson JA. The rat as an experimental model for sleep neurophysiology. Behav Neurosci 2000;114:1239-1244.
3. Blanco-Centurion C, Xu M, Murillo-Rodriguez E, Ger-ashchenko D, Shiromani AM, Salin-Pascual RJ, Hof PR, Shiromani PJ. Adenosine and sleep homeostasis in the basal forebrain. J Neurosci 2006;26:8092-8100.
4. Kim CS, Han J Y, Kim SH, Hong JT, Oh KW. Herbs for the treatment of insomnia. Biomol Ther 2011;19:274-281.
5. Kim CS, Jo YJ, Park SH, Kim HJ, Han JY, Hong JT, Cheong JH, Oh KW. Anti-stress effects of ginsenoside Rg3-standardized ginseng extract in restraint stressed animals. Biomol Ther 2010;18:219-225.
6. Lee SP, Honda K, Rhee YH, Inoue S. Chronic intake of Panax ginseng extract stabilizes sleep and wakefulness in food-deprived rats. Neurosci Lett 1990;111:217-221.
7. Xiang YZ, Shang HC, Gao XM, Zhang BL. A comparison of the ancient use of ginseng in traditional Chinese medicine with modern pharmacological experiments and clinical trials. Phytother Res 2008;22:851-858.
8. Kim SK, Park JH. Trends in ginseng research in 2010. J Ginseng Res 2011;35:389-398.
9. Choi HK, Seong DH, Rha KH. Clinical efficacy of Korean red ginseng for erectile dysfunction. Int J Impot Res 1995;7:181-186.
10. Yang SL, Nam SY, Han J Y, Kim JC, Lee K, Jin TH, Oh KW, Eun JS. Alterations of spontaneous sleep architecture and cortical electroencephalogram power spectra by red ginseng extract via GABAAergic systems. J Ginseng Res 2010;34:304-313.
11. Sanford LD, Yang L, Liu X, Tang X. Effects of tetrodo-toxin (TTX) inactivation of the central nucleus of the amygdala (CNA) on dark period sleep and activity. Brain Res 2006;1084:80-88.
12. Rhee YH, Lee SP, Honda K, Inoue S. Panax ginseng extract modulates sleep in unrestrained rats. Psychopharma-cology (Berl) 1990;101:486-488.
13. Kitaoka K, Uchida K, Okamoto N, Chikahisa S, Miyazaki T, Takeda E, Sei H. Fermented ginseng improves the fi rst-night effect in humans. Sleep 2009;32:413-421.
14. Lee DY, Cho JG, Lee MK, Lee JW, Lee YH, Yang DC, Baek NI. Discrimination of Panax ginseng roots cultivated in different areas in Korea using HPLC-ELSD and principal component analysis. J Ginseng Res 2011;35:31-38.
15. Kim MH, Lee YC, Choi SY, Cho CW, Rho J, Lee KW. The changes of ginsenoside patterns in red ginseng processed by organic acid impregnation pretreatment. J Ginseng Res 2011;35:497-503.
16. Samira MM, Attia MA, Allam M, Elwan O. Effect of the standardized ginseng extract G115 on the metabolism and electrical activity of the rabbit's brain. J Int Med Res 1985;13:342-348.
17. Kennedy DO, Scholey AB, Drewery L, Marsh VR, Moore B, Ashton H. Electroencephalograph effects of single doses of Ginkgo biloba and Panax ginseng in healthy young volunteers. Pharmacol Biochem Behav 2003;75:701-709.
18. Kaku T, Miyata T, Uruno T, Sako I, Kinoshita A. Chemi-co-pharmacological studies on saponins of Panax ginseng C. A. Meyer. II. Pharmacological part. Arzneimittelforsc-hung 1975;25:539-547.
19. Winsky-Sommerer R. Role of GABAA receptors in the physiology and pharmacology of sleep. Eur J Neurosci 2009;29:1779-1794.
20. Roth C, Achermann P, Borbely AA. Alpha activity in the human REM sleep EEG: topography and effect of REM sleep deprivation. Clin Neurophysiol 1999;110:632-635.
21. Bjorvatn B, Fagerland S, Ursin R. EEG power densities (0.5-20 Hz) in different sleep-wake stages in rats. Physiol Behav 1998;63:413-417.
22. Sieghart W. Structure and pharmacology of gamma-aminobutyric acidA receptor subtypes. Pharmacol Rev 1995;47:181-234.
23. Henny P, Jones BE. Vesicular glutamate (VGlut), GABA (VGAT), and acetylcholine (VACht) transporters in basal forebrain axon terminals innervating the lateral hypothal-amus. J Comp Neurol 2006;496:453-467.
24. Nitz D, Siegel JM. GABA release in posterior hypothala-mus across sleep-wake cycle. Am J Physiol 1996;271(6 Pt 2):R1707-R1712.
25. Gottesmann C. GABA mechanisms and sleep. Neurosci-ence 2002;111:231-239.
26. Sugiyama K, Muteki T, Kano T. The Japanese herbal medicine 'saiko-keishi-to' activates GABAA receptors of rat sensory neurons in culture. Neurosci Lett 1996; 216:147-150.
27. Nguyen TT, Matsumoto K, Yamasaki K, Watanabe H. Majonoside-R2 reverses social isolation stress-induced decrease in pentobarbital sleep in mice: possible involvement of neuroactive steroids. Life Sci 1997;61:395-402.
28. Kimura T, Saunders PA, Kim HS, Rheu HM, Oh KW, Ho IK. Interactions of ginsenosides with ligand-bindings of GABAA and GABAB receptors. Gen Pharmacol 1994;25:193-199.
29. Lee SH, Yang SC, Park JK, Jung MW, Lee CJ. Reduction of electrically evoked neural activity by ginseng saponin in rat hippocampal slices. Biol Pharm Bull 2000;23:411-414.