메뉴 건너뛰기




Volumn 52, Issue 1, 2013, Pages 181-188

Effects of combined treatment with eldecalcitol and alendronate on bone mass, mechanical properties, and bone histomorphometry in ovariectomized rats: A comparison with alfacalcidol and alendronate

Author keywords

Additive effect; Alendronate; Alfacalcidol; Combination therapy; ELD; Eldecalcitol

Indexed keywords

ALENDRONIC ACID; ALFACALCIDOL; ELDECALCITOL;

EID: 84867622282     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2012.09.031     Document Type: Article
Times cited : (18)

References (32)
  • 1
    • 0028556527 scopus 로고
    • Assessment of fracture risk and its application to screening for postmenopausal osteoporosis: synopsis of a WHO report. WHO Study Group
    • Kanis J.A. Assessment of fracture risk and its application to screening for postmenopausal osteoporosis: synopsis of a WHO report. WHO Study Group. Osteoporos Int 1994, 4:368-381.
    • (1994) Osteoporos Int , vol.4 , pp. 368-381
    • Kanis, J.A.1
  • 2
    • 26944488042 scopus 로고    scopus 로고
    • Animal models for fracture treatment in osteoporosis
    • Egermann M., Goldhahn J., Schneider E. Animal models for fracture treatment in osteoporosis. Osteoporos Int 2005, 16:129-138.
    • (2005) Osteoporos Int , vol.16 , pp. 129-138
    • Egermann, M.1    Goldhahn, J.2    Schneider, E.3
  • 3
    • 29144485522 scopus 로고    scopus 로고
    • Prevalence of vitamin D inadequacy in osteoporotic hip fracture patients in London
    • Moniz C., Dew T., Dixon T. Prevalence of vitamin D inadequacy in osteoporotic hip fracture patients in London. Curr Med Res Opin 2005, 21:1891-1894.
    • (2005) Curr Med Res Opin , vol.21 , pp. 1891-1894
    • Moniz, C.1    Dew, T.2    Dixon, T.3
  • 4
    • 29044439691 scopus 로고    scopus 로고
    • Half of the patients with an acute hip fracture suffer from hypovitaminosis D: a prospective study in southeastern Finland
    • Nurmi I., Kaukonen J.P., Luthje P., Naboulsi H., Tanninen S., Kataja M., et al. Half of the patients with an acute hip fracture suffer from hypovitaminosis D: a prospective study in southeastern Finland. Osteoporos Int 2005, 16:2018-2024.
    • (2005) Osteoporos Int , vol.16 , pp. 2018-2024
    • Nurmi, I.1    Kaukonen, J.P.2    Luthje, P.3    Naboulsi, H.4    Tanninen, S.5    Kataja, M.6
  • 5
    • 13144251144 scopus 로고    scopus 로고
    • Controlled trial of falecalcitriol versus alfacalcidol in suppression of parathyroid hormone in hemodialysis patients with secondary hyperparathyroidism
    • Akiba T., Marumo F., Owada A., Kurihara S., Inoue A., Chida Y., et al. Controlled trial of falecalcitriol versus alfacalcidol in suppression of parathyroid hormone in hemodialysis patients with secondary hyperparathyroidism. Am J Kidney Dis 1998, 32:238-246.
    • (1998) Am J Kidney Dis , vol.32 , pp. 238-246
    • Akiba, T.1    Marumo, F.2    Owada, A.3    Kurihara, S.4    Inoue, A.5    Chida, Y.6
  • 6
    • 0036679437 scopus 로고    scopus 로고
    • Meta-analyses of therapies for postmenopausal osteoporosis. VIII: meta-analysis of the efficacy of vitamin D treatment in preventing osteoporosis in postmenopausal women
    • Papadimitropoulos E., Wells G., Shea B., Gillespie W., Weaver B., Zytaruk N., et al. Meta-analyses of therapies for postmenopausal osteoporosis. VIII: meta-analysis of the efficacy of vitamin D treatment in preventing osteoporosis in postmenopausal women. Endocr Rev 2002, 23:560-569.
    • (2002) Endocr Rev , vol.23 , pp. 560-569
    • Papadimitropoulos, E.1    Wells, G.2    Shea, B.3    Gillespie, W.4    Weaver, B.5    Zytaruk, N.6
  • 7
    • 0031885374 scopus 로고    scopus 로고
    • Short-term prophylaxis against estrogen depletion-induced bone loss with calcitriol does not provide long-term beneficial effects on cancellous bone mass or structure in ovariectomized rats
    • Erbe R.G., Bromm S., Stangassinger M. Short-term prophylaxis against estrogen depletion-induced bone loss with calcitriol does not provide long-term beneficial effects on cancellous bone mass or structure in ovariectomized rats. Osteoporos Int 1998, 8:82-91.
    • (1998) Osteoporos Int , vol.8 , pp. 82-91
    • Erbe, R.G.1    Bromm, S.2    Stangassinger, M.3
  • 8
    • 0026690269 scopus 로고
    • Vitamin D metabolites prevent vertebral osteopenia in ovariectomized rats
    • Erben R.G., Weise H., Sinowatz F., Rambeck W.A., Zucke H. Vitamin D metabolites prevent vertebral osteopenia in ovariectomized rats. Calcif Tissue Int 1992, 50:228-236.
    • (1992) Calcif Tissue Int , vol.50 , pp. 228-236
    • Erben, R.G.1    Weise, H.2    Sinowatz, F.3    Rambeck, W.A.4    Zucke, H.5
  • 9
    • 0034062798 scopus 로고    scopus 로고
    • Alfacalcidol inhibits bone resorption and stimulates formation in an ovariectomized rat model of osteoporosis: distinct actions from estrogen
    • Shiraishi A., Takeda S., Masaki T., Higuchi Y., Uchiyama Y., Kubodera N., et al. Alfacalcidol inhibits bone resorption and stimulates formation in an ovariectomized rat model of osteoporosis: distinct actions from estrogen. J Bone Miner Res 2000, 15:770-779.
    • (2000) J Bone Miner Res , vol.15 , pp. 770-779
    • Shiraishi, A.1    Takeda, S.2    Masaki, T.3    Higuchi, Y.4    Uchiyama, Y.5    Kubodera, N.6
  • 10
    • 0021978965 scopus 로고
    • 1 alpha-Hydroxyvitamin D2 is less toxic than 1 alpha-hydroxyvitamin D3 in the rat
    • Sjöden G., Smith C., Lindgren U., DeLuca H.F. 1 alpha-Hydroxyvitamin D2 is less toxic than 1 alpha-hydroxyvitamin D3 in the rat. Proc Soc Exp Biol Med 1985, 178:432-436.
    • (1985) Proc Soc Exp Biol Med , vol.178 , pp. 432-436
    • Sjöden, G.1    Smith, C.2    Lindgren, U.3    DeLuca, H.F.4
  • 11
    • 0030831553 scopus 로고    scopus 로고
    • Short-term treatment of rats with high dose 1,25-dihydroxyvitamin D3 stimulates bone formation and increases the number of osteoblast precursor cells in bone marrow
    • Erben R.G., Scutt A.M., Miao D., Kollenkirchen U., Haberey M. Short-term treatment of rats with high dose 1,25-dihydroxyvitamin D3 stimulates bone formation and increases the number of osteoblast precursor cells in bone marrow. Endocrinology 1997, 138:4629-4635.
    • (1997) Endocrinology , vol.138 , pp. 4629-4635
    • Erben, R.G.1    Scutt, A.M.2    Miao, D.3    Kollenkirchen, U.4    Haberey, M.5
  • 12
    • 0031595068 scopus 로고    scopus 로고
    • Therapeutic efficacy of 1α,25-dihydroxyvitamin D3 and calcium in osteopenic ovariectomized rats: evidence for a direct anabolic effect of 1α,25-dihydroxyvitamin D3 on bone
    • Erben R.G., Bromm S., Stangassinger M. Therapeutic efficacy of 1α,25-dihydroxyvitamin D3 and calcium in osteopenic ovariectomized rats: evidence for a direct anabolic effect of 1α,25-dihydroxyvitamin D3 on bone. Endocrinology 1998, 139:4319-4328.
    • (1998) Endocrinology , vol.139 , pp. 4319-4328
    • Erben, R.G.1    Bromm, S.2    Stangassinger, M.3
  • 13
    • 0036210478 scopus 로고    scopus 로고
    • ED-71, a vitamin D analog, is a more potent inhibitor of bone resorption than alfacalcidol in an estrogen-deficient rat model of osteoporosis
    • Uchiyama Y., Higuchi Y., Takeda S., Masaki T., Shira-ishi A., Sato K., et al. ED-71, a vitamin D analog, is a more potent inhibitor of bone resorption than alfacalcidol in an estrogen-deficient rat model of osteoporosis. Bone 2002, 30:582-588.
    • (2002) Bone , vol.30 , pp. 582-588
    • Uchiyama, Y.1    Higuchi, Y.2    Takeda, S.3    Masaki, T.4    Shira-ishi, A.5    Sato, K.6
  • 14
    • 13044293395 scopus 로고    scopus 로고
    • Syntheses and preventive effects of analogues related to alpha,25-dihydroxy-2beta-(3-hydroxypropoxy) vitamin D3 (ED-71) on bone mineral loss in ovariectomized rats
    • Ono Y., Kawase A., Watanabe H., Shiraishi A., Takeda S., Higuchi Y., et al. Syntheses and preventive effects of analogues related to alpha,25-dihydroxy-2beta-(3-hydroxypropoxy) vitamin D3 (ED-71) on bone mineral loss in ovariectomized rats. Bioorg Med Chem 1998, 6:2517-2523.
    • (1998) Bioorg Med Chem , vol.6 , pp. 2517-2523
    • Ono, Y.1    Kawase, A.2    Watanabe, H.3    Shiraishi, A.4    Takeda, S.5    Higuchi, Y.6
  • 15
    • 24344474407 scopus 로고    scopus 로고
    • A new active vitamin D, ED-71, increases bone mass in osteoporotic patients under vitamin D supplementation: a randomized, double-blind, placebo-controlled clinical trial
    • Matsumoto T., Miki T., Hagino H., Sugimoto T., Okamoto S., Hirota T., et al. A new active vitamin D, ED-71, increases bone mass in osteoporotic patients under vitamin D supplementation: a randomized, double-blind, placebo-controlled clinical trial. J Clin Endocrinol Metab 2005, 90:5031-5036.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 5031-5036
    • Matsumoto, T.1    Miki, T.2    Hagino, H.3    Sugimoto, T.4    Okamoto, S.5    Hirota, T.6
  • 16
    • 80052278079 scopus 로고    scopus 로고
    • 3 analog, eldecalcitol, prevents the risk of osteoporotic fractures - a randomized, active comparator, double-blind study
    • 3 analog, eldecalcitol, prevents the risk of osteoporotic fractures - a randomized, active comparator, double-blind study. Bone 2011, 49:605-612.
    • (2011) Bone , vol.49 , pp. 605-612
    • Matsumoto, T.1    Ito, M.2    Hayashi, Y.3    Hirota, T.4    Tanigawara, Y.5    Sone, T.6
  • 17
    • 0031865941 scopus 로고    scopus 로고
    • Alendronate reduces adhesion of human osteoclast-like cells to bone and bone protein-coated surfaces
    • Colucci S., Minielli V., Zambonin G., Cirulli N., Mori G., Serra M., et al. Alendronate reduces adhesion of human osteoclast-like cells to bone and bone protein-coated surfaces. Calcif Tissue Int 1998, 63:230-235.
    • (1998) Calcif Tissue Int , vol.63 , pp. 230-235
    • Colucci, S.1    Minielli, V.2    Zambonin, G.3    Cirulli, N.4    Mori, G.5    Serra, M.6
  • 18
    • 0029164610 scopus 로고
    • Alendronate distributed on bone surfaces inhibits osteoclastic bone resorption in vitro and in experimental hypercalcemia models
    • Azuma Y., Sato H., Oue Y., Okabe K., Ohta T., Tsuchimoto M., et al. Alendronate distributed on bone surfaces inhibits osteoclastic bone resorption in vitro and in experimental hypercalcemia models. Bone 1995, 16:235-245.
    • (1995) Bone , vol.16 , pp. 235-245
    • Azuma, Y.1    Sato, H.2    Oue, Y.3    Okabe, K.4    Ohta, T.5    Tsuchimoto, M.6
  • 19
    • 0028851590 scopus 로고
    • Effect of oral alendronate on bone mineral density and the incidence of fractures in postmenopausal osteoporosis. The Alendronate Phase III Osteoporosis Treatment Study Group
    • Liberman U.A., Weiss S.R., Bröll J., Minne H.W., Quan H., Bell N.H., et al. Effect of oral alendronate on bone mineral density and the incidence of fractures in postmenopausal osteoporosis. The Alendronate Phase III Osteoporosis Treatment Study Group. N Engl J Med 1995, 333:1437-1443.
    • (1995) N Engl J Med , vol.333 , pp. 1437-1443
    • Liberman, U.A.1    Weiss, S.R.2    Bröll, J.3    Minne, H.W.4    Quan, H.5    Bell, N.H.6
  • 20
    • 0034530951 scopus 로고    scopus 로고
    • Fracture Intervention Trial. Fracture risk reduction with alendronate in women with osteoporosis: the Fracture Intervention Trial. FIT Research Group
    • Black D.M., Thompson D.E., Bauer D.C., Ensrud K., Musliner T., Hochberg M.C., et al. Fracture Intervention Trial. Fracture risk reduction with alendronate in women with osteoporosis: the Fracture Intervention Trial. FIT Research Group. J Clin Endocrinol Metab 2000, 85:4118-4124.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 4118-4124
    • Black, D.M.1    Thompson, D.E.2    Bauer, D.C.3    Ensrud, K.4    Musliner, T.5    Hochberg, M.C.6
  • 21
    • 0031821629 scopus 로고    scopus 로고
    • Effects of continuous alendronate treatment on bone mass and mechanical properties in ovariectomized rats: comparison with pamidronate and etidronate in growing rats
    • Azuma Y., Oue Y., Kanatani H., Ohta T., Kiyoki M., Komoriya K. Effects of continuous alendronate treatment on bone mass and mechanical properties in ovariectomized rats: comparison with pamidronate and etidronate in growing rats. J Pharmacol Exp Ther 1998, 286:128-135.
    • (1998) J Pharmacol Exp Ther , vol.286 , pp. 128-135
    • Azuma, Y.1    Oue, Y.2    Kanatani, H.3    Ohta, T.4    Kiyoki, M.5    Komoriya, K.6
  • 22
    • 0032468984 scopus 로고    scopus 로고
    • Bisphosphonates: mechanisms of action
    • Fleisch H. Bisphosphonates: mechanisms of action. Endocr Rev 1998, 19:80-100.
    • (1998) Endocr Rev , vol.19 , pp. 80-100
    • Fleisch, H.1
  • 23
    • 84857988635 scopus 로고    scopus 로고
    • Combination therapy with alendronate and eldecalcitol has therapeutic advantages over monotherapy by improving bone strength
    • Sakai S., Endo K., Takeda S., Mihara M., Shiraishi A. Combination therapy with alendronate and eldecalcitol has therapeutic advantages over monotherapy by improving bone strength. Bone 2012, 50:1054-1063.
    • (2012) Bone , vol.50 , pp. 1054-1063
    • Sakai, S.1    Endo, K.2    Takeda, S.3    Mihara, M.4    Shiraishi, A.5
  • 24
    • 0027479827 scopus 로고
    • The effects of aging and ovariectomy on the vertebral bone mass and biomechanical properties of mature rats
    • Mosekilde L., Danielsen C.C., Knudsen U.B. The effects of aging and ovariectomy on the vertebral bone mass and biomechanical properties of mature rats. Bone 1993, 14:1-6.
    • (1993) Bone , vol.14 , pp. 1-6
    • Mosekilde, L.1    Danielsen, C.C.2    Knudsen, U.B.3
  • 25
    • 0029070879 scopus 로고
    • Intermittent cyclical etidronate treatment maintains the mass, structure and the mechanical property of bone in ovariectomized rats
    • Katsumata T., Nakamura T., Ohnishi H., Sakurama T. Intermittent cyclical etidronate treatment maintains the mass, structure and the mechanical property of bone in ovariectomized rats. J Bone Miner Res 1995, 10:921-931.
    • (1995) J Bone Miner Res , vol.10 , pp. 921-931
    • Katsumata, T.1    Nakamura, T.2    Ohnishi, H.3    Sakurama, T.4
  • 26
    • 0028202499 scopus 로고
    • Preclinical pharmacology of CGP 42'446, a new, potent, heterocyclic bisphosphonate compound
    • Green J.R., Müller K., Jaeggi K.A. Preclinical pharmacology of CGP 42'446, a new, potent, heterocyclic bisphosphonate compound. J Bone Miner Res 1994, 9:745-752.
    • (1994) J Bone Miner Res , vol.9 , pp. 745-752
    • Green, J.R.1    Müller, K.2    Jaeggi, K.A.3
  • 27
    • 0023488581 scopus 로고
    • Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee
    • Parfitt A.M., Drezner M.K., Glorieux F.H., Kanis J.A., Malluche H., Meunier P.J., et al. Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Miner Res 1987, 2:595-610.
    • (1987) J Bone Miner Res , vol.2 , pp. 595-610
    • Parfitt, A.M.1    Drezner, M.K.2    Glorieux, F.H.3    Kanis, J.A.4    Malluche, H.5    Meunier, P.J.6
  • 28
    • 79960579823 scopus 로고    scopus 로고
    • Eldecalcitol, a second-generation vitamin D analog, drives bone minimodeling and reduces osteoclastic number in trabecular bone of ovariectomized rats
    • de Freitas P.H., Hasegawa T., Takeda S., Sasaki M., Tabata C., Oda K., et al. Eldecalcitol, a second-generation vitamin D analog, drives bone minimodeling and reduces osteoclastic number in trabecular bone of ovariectomized rats. Bone 2011, 49:335-342.
    • (2011) Bone , vol.49 , pp. 335-342
    • de Freitas, P.H.1    Hasegawa, T.2    Takeda, S.3    Sasaki, M.4    Tabata, C.5    Oda, K.6
  • 29
    • 0030868816 scopus 로고    scopus 로고
    • Histomorphometric assessment of the long-term effects of alendronate on bone quality and remodeling in patients with osteoporosis
    • Chavassieux P.M., Arlot M.E., Reda C., Wei L., Yates A.J., Meunier P.J. Histomorphometric assessment of the long-term effects of alendronate on bone quality and remodeling in patients with osteoporosis. J Clin Invest 1997, 100:1475-1480.
    • (1997) J Clin Invest , vol.100 , pp. 1475-1480
    • Chavassieux, P.M.1    Arlot, M.E.2    Reda, C.3    Wei, L.4    Yates, A.J.5    Meunier, P.J.6
  • 30
  • 31
    • 0036128709 scopus 로고    scopus 로고
    • Biomechanics of bone: determinants of skeletal fragility and bone quality.
    • Turner C.H. Biomechanics of bone: determinants of skeletal fragility and bone quality. Osteoporos Int 2002, 13:97-104.
    • (2002) Osteoporos Int , vol.13 , pp. 97-104
    • Turner, C.H.1
  • 32
    • 49549114063 scopus 로고    scopus 로고
    • Collagen maturity, glycation induced-pentosidine, and mineralization are increased following 3-year treatment with incadronate in dogs
    • Saito M., Mori S., Mashiba T., Komatsubara S., Marumo K. Collagen maturity, glycation induced-pentosidine, and mineralization are increased following 3-year treatment with incadronate in dogs. Osteoporos Int 2008, 19:1343-1354.
    • (2008) Osteoporos Int , vol.19 , pp. 1343-1354
    • Saito, M.1    Mori, S.2    Mashiba, T.3    Komatsubara, S.4    Marumo, K.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.