Short-term prophylaxis against estrogen depletion-induced bone loss with calcitriol does not provide long-term beneficial effects on cancellous bone mass or structure in ovariectomized rats

Osteoporosis International

Volumn 8, Issue 1, 1998, Pages 82-91

  Erben, R G ^a   Bromm, S ^a   Stangassinger, M ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Histomorphometry; Osteoporosis; Ovariectomy; Rats; Vitamin D

Indexed keywords

CALCITRIOL; ESTROGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE ATROPHY; BONE MASS; BONE STRUCTURE; CANCELLOUS BONE; CONTROLLED STUDY; FEMALE; METAPHYSIS; MORPHOMETRICS; NONHUMAN; ORAL DRUG ADMINISTRATION; OSTEOPOROSIS; OVARIECTOMY; PRIORITY JOURNAL; RAT; TIBIA; VERTEBRA BODY;

ANALYSIS OF VARIANCE; ANIMALS; BONE DENSITY; CALCITRIOL; FEMALE; LUMBAR VERTEBRAE; OSTEOPOROSIS; OVARIECTOMY; RATS; RATS, INBRED F344; TIBIA; TIME FACTORS;

EID: 0031885374     PISSN: 0937941X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001980050052     Document Type: Article

References (35)

1. Heaney RP, Recker RR, Saville PD. Menopausal changes in bone remodeling. J Lab Clin Med 1978;92:964-70.
2. Falch JA, Sandvik L. Perimenopausal appendicular bone loss: a 10-year prospective study. Bone 1990;11:425-8.
3. Stepan JJ, Pospichal J, Presl J, Pacovsky V. Bone loss and biochemical indices of bone remodeling in surgically induced postmenopausal women. Bone 1987;8:279-84.
4. Stepan JJ, Pospichal J, Schreiber V, et al. The application of plasma tartrate-resistant acid phosphatase to assess changes in bone resorption in response to artificial menopause and its treatment with estrogen or norethisterone. Calcif Tissue Int 1989;45:273-80.
5. Turner RT, Rigss BL, Spelsberg TC. Skeletal effects of estrogen. Endocr Rev 1994;15:275-300.
6. Parfitt AM. Trabecular bone architecture in the pathogenesis and prevention of fracture. Am J Med 1987;82(Suppl 1B):68-72.
7. Cohen-Solal ME, Shin M-S, Lundy MW, Parfitt AM. A new method for measuring cancellous bone erosion depth: application to the cellular mechanisms of bone loss in postmenopausal osteoporosis. J Bone Miner Res 1991;6:1331-8.
8. Parfitt AM, Villanueva AR, Foldes J, Rao DS. Relations between histologic indices of bone formation: implications for the pathogenesis of spinal osteoporosis. J Bone Miner Res 1995;10:466-73.
9. Lindsay R, MacLean A, Kraszewki A, Hart DM, Clark AC, Garwood J. Bone response to termination of estrogen treatment. Lancet 1978;2:1325-7.
10. Wronski TJ, Cintron M, Dann LM. Temporal relationship between bone loss and increased bone turnover in ovariectomized rats. Calcif Tissue Int 1988;43:179-83.
11. Wronski TJ, Dann LM, Horner SL. Time course of vertebral osteopenia in ovariectomized rats. Bone 1989;10:295-301.
12. Wronski TJ, Dann LM, Qi H, Yen C-F. Skeletal effects of withdrawal of estrogen and diphosphonate treatment in ovariectomized rats. Calcif Tissue Int 1993;53:210-6.
13. Kimble RB, Kitazawa R, Vannice JL, Pacifici R. Persistent bone-sparing effect of interleukin-1 receptor antagonist: a hypothesis on the role of IL-1 in ovariectomy-induced bone loss. Calcif Tissue Int 1994;55:260-5
14. Shen Y, Li M, Wronski TJ Skeletal effects of calcitonin treatment and withdrawal in ovariectomized rats. Calcif Tissue Int 1996;58:263-7.
15. 3 analogs on osteoporosis caused by ovariectomy in rats. Acta Vitaminol Enzymol 1985;7 173-81.
16. Erben RG, Kohn B, Weiser H, Sinowatz F, Rambeck WA. Role of vitamin D metabolites in the prevention of the osteopenia induced by ovariectomy in the axial and appendicular skeleton of the rat. Z Emahrungswiss 1990;29:229-48.
17. Erben RG, Weiser H, Sinowatz F, Rambeck WA, Zucker H. Vitamin D metabolites prevent vertebral osteopenia in ovariectomized rats. Calcif Tissue Int 1992;50:228-36.
18. 2 partially dissociates between preservation of cancellous bone mass and effects on calcium homeostasis in ovariectomized rats. Calcif Tissue Int 1997;60:449-56.
19. 3 on ovariectomy-induced cancellous bone loss in the rat. Calcif Tissue Int 1997;60:434-40.
20. Colwell A, Russell RGG, Eastell R. Factors affecting the assay of urinary 3-hydroxypyridinium crosslinks of collagen as markers of bone resorption. Eur J Clin Invest 1993;23:341-9.
21. Schenk RK, Olah AJ, Herrmann W. Preparation of calcified tissues for light microscopy. In: Dickson GR, editor. Methods of calcified tissue preparation. Amsterdam: Elsevier, 1984:1-56.
22. Erben RG, Kohn B, Rambeck WA, Zucker H. Histomorphometric analysis of the rat proximal tibial metaphysis by 'linear scanning'. Scanning Microsc 1990;4:625-38.
23. Baron R, Vignery A, Neff L, Silverglate A, Santa Maria A. Processing of undecalcified bone specimens for bone histomorphometry. In: Recker RR, editor. Bone histomorphometry: techniques and interpretation. Boca Raton, FL: CRC Press, 1983:13-35.
24. Parfitt AM, Drezner MK, Glorieux FH, et al. Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Miner Res 1987;2:595-610.
25. 3-treated rats fed high levels of dietary calcium. Bone 1985;6:105-12.
26. 3: increased bone but impaired mineralization. Endocrinology 1986;119:2580-5.
27. Ishibe M, Nojima T, Ishibashi T, et al. 17β-estradiol increases the receptor number and modulates the action of 1,25-dihydroxyvitamin D3 in human osteosarcoma-derived osteoblast-like cells. Calcif Tissue Int 1995;57:430-5.
28. 3 and its receptors in osteoblasts and osteocytes from neonatal mouse and rat calvaria. Bone Miner 1987;3:125-36.
29. 3 in bones from fetal rats. Calcif Tissue Int 1983;35:177-82.
30. 3 stimulates bone turnover in the normal young mouse. Calcif Tissue Int 1983;35:418-25.
31. Gallagher JC, Recker RR. A comparison of the effects of calcitriol or calcium supplements on bone in postmenopausal osteoporosis. In: Norman AW, Schaefer, K. Grigoleit H-G, von Herrath D, editors. Vitamin D: chemical, biochemical and clinical update. Berlin: Walter de Gruyter, 1985:971-5.
32. Malluche HH, Matthews C, Faugere MC, Fanti P, Endres DB, Friedler RM. 1,25-Dihydroxyvitamin D maintains bone cell activity, and parathyroid hormone modulates bone cell number in dogs. Endocrinology 1986;119:1298-304.
33. 3 in long bones of rats. Calcif Tissue Int 1986;38:79-86.
34. Erben RG. Trabecular and endocortical bone surfaces in the rat: modeling or remodeling? Anat Rec 1996;246:39-46.
35. Frost HM. Bone 'mass' and the 'mechanostat': a proposal. Anat Rec 1987;219:1-9.