The paneth cell, caloric restriction, and intestinal integrity

New England Journal of Medicine

Volumn 367, Issue 16, 2012, Pages 1560-1561

  Clevers, Hans ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

DEFENSIN; LYSOZYME; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; RAPAMYCIN;

ARTICLE; CALORIC RESTRICTION; CELL ACTIVITY; CELL COMPARTMENTALIZATION; CELL COUNT; CELL CULTURE; CELL DIFFERENTIATION; CELL EXPANSION; CELL FUNCTION; CELL GROWTH; CELL MOTION; CELL PROLIFERATION; CRYPT CELL; HUMAN; INTESTINE EPITHELIUM; NONHUMAN; NUTRITIONAL STATUS; PANETH CELL; PRIORITY JOURNAL; SMALL INTESTINE;

EID: 84867618674     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMcibr1208353     Document Type: Article

References (4)

1. Yilmaz OH, Katajisto P, Lamming DW, et al. mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake. Nature 2012;486:490-5.
2. Ouellette AJ. Paneth cells and innate mucosal immunity. Curr Opin Gastroenterol 2010;26:547-53.
3. Cheng H, Leblond CP. Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. V. Unitarian theory of the origin of the four epithelial cell types. Am J Anat 1974;141:537-61.
4. Sato T, van Es JH, Snippert HJ, et al. Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts. Nature 2011;469:415-8.