HCV NS5A Protein Containing Potential Ligands for Both Src Homology 2 and 3 Domains Enhances Autophosphorylation of Src Family Kinase Fyn in B Cells

PLoS ONE

Volumn 7, Issue 10, 2012, Pages

  Nakashima, Kenji ^a   Takeuchi, Kenji ^a   Chihara, Kazuyasu ^a   Horiguchi, Tomoko ^a   Sun, Xuedong ^a   Deng, Lin ^b   Shoji, Ikuo ^b   Hotta, Hak ^b   Sada, Kiyonao ^a  

^a UNIVERSITY OF FUKUI   (Japan)

^b KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; GLUTATHIONE TRANSFERASE; LIGAND; LYSINE; NONSTRUCTURAL PROTEIN 5A; PERVANADATE; PROTEIN KINASE FYN; PROTEIN SH2; PROTEIN SH3; TYROSINE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; AUTOPHOSPHORYLATION; B LYMPHOCYTE; CONTROLLED STUDY; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; LIPID RAFT; NONHUMAN; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION;

B-LYMPHOCYTES; BASE SEQUENCE; CELL LINE, TUMOR; DNA PRIMERS; HUMANS; LIGANDS; PHOSPHORYLATION; POLYMERASE CHAIN REACTION; PROTO-ONCOGENE PROTEINS C-FYN; SRC HOMOLOGY DOMAINS; VIRAL NONSTRUCTURAL PROTEINS;

EID: 84867607886     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0046634     Document Type: Article

References (26)

1. Moradpour D, Penin F, Rice CM, (2007) Replication of hepatitis C virus. Nat Rev Microbiol 5: 453-463.
2. Suzuki T, Aizaki H, Murakami K, Shoji I, Wakita T, (2007) Molecular biology of hepatitis C virus. J Gastroenterol 42: 411-423.
3. Agnello V, Chung RT, Kaplan LM, (1992) A role for hepatitis C virus infection in type II cryoglobulinemia. New Engl J Med 327: 1490-1495.
4. Morsica G, Tambussi G, Sitia G, Novati R, Lazzarin A, et al. (1999) Replication of hepatitis C virus in B lymphocytes (CD19(+)). Blood 94: 1138-1139.
5. Gisbert JP, Garcia-Buey L, Pajares JM, Moreno-Otero R, (2003) Prevalence of hepatitis C virus infection in B-cell non-Hodgkin's lymphoma: Systematic review and meta-analysis. Gastroenterology 125: 1723-1732.
6. Machida K, Cheng KTH, Pavio N, Sung VMH, Lai MMC, (2005) Hepatitis C virus E2-CD81 interaction induces hypermutation of the immunoglobulin gene in B cells. J Virol 79: 8079-8089.
7. Ito M, Murakami K, Suzuki T, Mochida K, Suzuki M, et al. (2010) Enhanced expression of lymphomagenesis-related genes in peripheral blood B cells of chronic hepatitis C patients. Clin Immunol 135: 459-465.
8. Saito YD, Jensen AR, Salgia R, Posadas EM, (2010) Fyn A Novel Molecular Target in Cancer. Cancer 116: 1629-1637.
9. Macdonald A, Crowder K, Street A, McCormick C, Harris M, (2004) The hepatitis C virus NS5A protein binds to members of the Src family of tyrosine kinases and regulates kinase activity. J Gen Virol 85: 721-729.
10. Bradshaw JM, (2010) The Src, Syk, and Tec family kinases: Distinct types of molecular switches. Cell Signal 22: 1175-1184.
11. Inubushi S, Nagano-Fujii M, Kitayama K, Tanaka M, An C, et al. (2008) Hepatitis C virus NS5A protein interacts with and negatively regulates the non-receptor protein tyrosine kinase Syk. J Gen Virol 89: 1231-1242.
12. Pfannkuche A, Buther K, Karthe J, Poenisch M, Bartenschlager R, et al. (2011) c-Src is required for complex formation between the hepatitis C virus-encoded proteins NS5A and NS5B: A prerequisite for replication. Hepatology 53: 1127-1136.
13. Ishido S, Choi JK, Lee BS, Wang CY, DeMaria M, et al. (2000) Inhibition of natural killer cell-mediated cytotoxicity by kaposi's sarcoma-associated herpesvirus K5 protein. Immunity 13: 365-374.
14. Ogi K, Nakashima K, Chihara K, Takeuchi K, Horiguchi T, et al. (2011) Enhancement of B-cell receptor signaling by a point mutation of adaptor protein 3BP2 identified in human inherited disease cherubism. Genes Cells 16: 951-960.
15. Sada K, Miah SM, Maeno K, Kyo S, Qu X, et al. (2002) Regulation of FcεRI-mediated degranulation by an adaptor protein 3BP2 in rat basophilic leukemia RBL-2H3 cells. Blood 100: 2138-2144.
16. Rao N, Ghosh AK, Ota S, Zhou P, Reddi AL, et al. (2001) The non-receptor tyrosine kinase Syk is a target of Cbl-mediated ubiquitylation upon B-cell receptor stimulation. EMBO J 20: 7085-7095.
17. Shukla U, Hatani T, Nakashima K, Ogi K, Sada K, (2009) Tyrosine Phosphorylation of 3BP2 Regulates B Cell Receptor-mediated Activation of NFAT. J Biol Chem 284: 33719-33728.
18. Blight KJ, McKeating JA, Rice CM, (2002) Highly permissive cell lines for subgenomic and genomic hepatitis C virus RNA replication. J Virol 76: 13001-13014.
19. Nakashima K, Takeuchi K, Chihara K, Hotta H, Sada K, (2011) Inhibition of hepatitis C virus replication through adenosine monophosphate-activated protein kinase-dependent and-independent pathways. Microbiol Immunol 55: 774-782.
20. Maeno K, Sada K, Kyo S, Miah SM, Kawauchi-Kamata K, et al. (2003) Adaptor protein 3BP2 is a potential ligand of Src homology 2 and 3 domains of Lyn protein-tyrosine kinase. J Biol Chem 278: 24912-24920.
21. Miah SM, Hatani T, Qu X, Yamamura H, Sada K, (2004) Point mutations of 3BP2 identified in human inherited disease cherubism results in the loss of function. Genes Cells 9: 993-1004.
22. Chihara K, Nakashima K, Takeuchi K, Sada K, (2011) Association of 3BP2 with SHP-1 regulates SHP-1-mediated production of TNF-α in RBL-2H3 cells. Genes Cells 16: 1133-1145.
23. Qu X, Sada K, Kyo S, Maeno K, Miah SM, et al. (2004) Negative regulation of FcεRI-mediated mast cell activation by a ubiquitin-protein ligase Cbl-b. Blood 103: 1779-1786.
24. Shelton H, Harris M, (2008) Hepatitis C virus NS5A protein binds the SH3 domain of the Fyn tyrosine kinase with high affinity: mutagenic analysis of residues within the SH3 domain that contribute to the interaction. Virol J 5: 24 Available: http://www.virologyj.com/content/5/1/24.
25. Supekova L, Supek F, Lee J, Chen S, Gray N, et al. (2008) Identification of human kinases involved in hepatitis C virus replication by small interference RNA library screening. J Biol Chem 283: 29-36.
26. Birge RB, Kalodimos C, Inagaki F, Tanaka S, (2009) Crk and CrkL adaptor proteins: networks for physiological and pathological signaling. Cell Commun Signal 7: 13 Available: http://www.biosignaling.com/content/7/1/13.