Topical neutralization of interleukin-17 during experimental Pseudomonas aeruginosa corneal infection promotes bacterial clearance and reduces pathology

Infection and Immunity

Volumn 80, Issue 10, 2012, Pages 3706-3712

  Zaidi, Tanweer S ^a,b   Zaidi, Tauqeer ^a,b   Pier, Gerald B ^a,b   Priebe, Gregory P ^a,b,c  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 17; INTERLEUKIN 17 ANTIBODY; INTERLEUKIN 17 RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL CLEARANCE; BACTERIAL COUNT; BACTERIAL STRAIN; CONTROLLED STUDY; EYE INJURY; IMMUNE RESPONSE; INFECTION RESISTANCE; KERATITIS; MOUSE; NEUTROPHIL; NONHUMAN; PATHOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTION; SCORING SYSTEM; SCRATCHING;

ANIMALS; ANTIBODIES, NEUTRALIZING; CORNEAL ULCER; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; INTERCELLULAR ADHESION MOLECULE-1; INTERLEUKIN-17; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; RECEPTORS, INTERLEUKIN-17;

EID: 84867600106     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.00249-12     Document Type: Article

References (40)

1. Albanesi C, Cavani A, Girolomoni G. 1999. IL-17 is produced by nickelspecific T lymphocytes and regulates ICAM-1 expression and chemokine production in human keratinocytes: synergistic or antagonist effects with IFN-gamma and TNF-alpha. J. Immunol. 162:494-502.
2. Alexandrakis G, Alfonso EC, Miller D. 2000. Shifting trends in bacterial keratitis in south Florida and emerging resistance to fluoroquinolones. Ophthalmology 107:1497-1502.
3. Allewelt M, Coleman FT, Grout M, Priebe GP, Pier GB. 2000. Acquisition of expression of the P. aeruginosa ExoU cytotoxin leads to increased bacterial virulence in a murine model of acute pneumonia and systemic spread. Infect. Immun. 68:3998-4004.
4. Berk RS, Hazlett LD, Beisel KW. 1987. Genetic studies on resistance and susceptibility genes controlling the mouse cornea to infection by Pseudomonas aeruginosa. Antibiot. Chemother. 39:83-91.
5. Bullard DC, et al. 2007. Intercellular adhesion molecule-1 expression is required on multiple cell types for the development of experimental autoimmune encephalomyelitis. J. Immunol. 178:851-857.
6. Buonocore S, et al. 2010. Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology. Nature 464:1371-1375.
7. Cua DJ, Tato CM. 2010. Innate IL-17-producing cells: the sentinels of the immune system. Nat. Rev. Immunol. 10:479-489.
8. Cupedo T, et al. 2009. Human fetal lymphoid tissue-inducer cells are interleukin 17-producing precursors to RORC+ CD127+ natural killerlike cells. Nat. Immunol. 10:66-74.
9. Fleiszig SM, Zaidi TS, Fletcher EL, Preston MJ, Pier GB. 1994. Pseudomonas aeruginosa invades corneal epithelial cells during experimental infection. Infect. Immun. 62:3485-3493.
10. Fleiszig SM, Zaidi TS, Pier GB. 1995. Pseudomonas aeruginosa invasion of and multiplication within corneal epithelial cells in vitro. Infect. Immun. 63:4072-4077.
11. Freitas A, et al. 2009. IL-17 receptor signaling is required to control polymicrobial sepsis. J. Immunol. 182:7846-7854.
12. Gagen D, et al. 2010. ICAM-1 mediates surface contact between neutrophils and keratocytes following corneal epithelial abrasion in the mouse. Exp. Eye Res. 91:676-684.
13. Galentine PG, et al. 1984. Corneal ulcers associated with contact lens wear. Arch. Ophthalmol. 102:891-894.
14. Hazlett LD. 2002. Pathogenic mechanisms of P. aeruginosa keratitis: a review of the role of T cells, Langerhans cells, PMN, and cytokines. DNA Cell. Biol. 21:383-390.
15. Hazlett LD, McClellan S, Kwon B, Barrett R. 2000. Increased severity of Pseudomonas aeruginosa corneal infection in strains of mice designated as Th1 versus Th2 responsive. Invest. Ophthalmol. Vis. Sci. 41:805-810.
16. Hazlett LD, Rosen DD, Berk RS. 1977. Pseudomonas eye infections in cyclophosphamide-treated mice. Invest. Ophthalmol. Vis. Sci. 16:649-652.
17. Hobden JA, Masinick-McClellan S, Barrett RP, Bark KS, Hazlett LD. 1999. Pseudomonas aeruginosa keratitis in knockout mice deficient in intercellular adhesion molecule 1. Infect. Immun. 67:972-975.
18. Kernacki KA, Berk RS. 1994. Characterization of the inflammatory response induced by corneal infection with Pseudomonas aeruginosa. J. Ocul. Pharmacol. 10:281-288.
19. King PD, et al. 1995. Novel isoforms of murine intercellular adhesion molecule-1 generated by alternativeRNAsplicing. J. Immunol. 154:6080-6093.
20. Li L, et al. 2010. IL-17 produced by neutrophils regulates IFN-gammamediated neutrophil migration in mouse kidney ischemia-reperfusion injury. J. Clin. Invest. 120:331-342.
21. Linden A, Laan M, Anderson GP. 2005. Neutrophils, interleukin-17A and lung disease. Eur. Respir. J. 25:159-172.
22. Martin B, Hirota K, Cua DJ, Stockinger B, Veldhoen M. 2009. Interleukin-17-producing gamma-delta T cells selectively expand in response to pathogen products and environmental signals. Immunity 31:321-330.
23. Michel ML, et al. 2008. Critical role of ROR-gammat in a new thymic pathway leading to IL-17-producing invariant NKT cell differentiation. Proc. Nat. Acad. Sci. U. S. A. 105:19845-19850.
24. Molesworth-Kenyon SJ, Yin R, Oakes JE, Lausch RN. 2008. IL-17 receptor signaling influences virus-induced corneal inflammation. J. Leukoc. Biol. 83:401-408.
25. Peck A, Mellins ED. 2010. Precarious balance: Th17 cells in host defense. Infect. Immun. 78:32-38.
26. Preston MJ, et al. 1995. Rapid and sensitive method for evaluating Pseudomonas aeruginosa virulence factors during corneal infections in mice. Infect. Immun. 63:3497-3501.
27. Priebe G, et al. 2008. IL-17 is a critical component of vaccine-induced protection against lung infection by LPS-heterologous strains of Pseudomonas aeruginosa. J. Immunol. 181:4965-4975.
28. Roussel L, et al. 2010. IL-17 promotes p38 MAPK-dependent endothelial activation enhancing neutrophil recruitment to sites of inflammation. J. Immunol. 184:4531-4537.
29. Schein OD, Glynn RJ, Seddon JM, Scardino VA, Kenyon KR. 1989. The relative risk of ulcerative keratitis among users of daily-wear and extended-wear soft contact lenses. N. Engl. J. Med. 321:773-778.
30. Sugita S, et al. 2012. Inhibitory effect of corneal endothelial cells on IL-17-producing Th17 cells. Br. J. Ophthalmol. 96:293-299.
31. Sun Y, Karmakar M, Taylor PR, Rietsch A, Pearlman E. 2012. ExoS and ExoT ADP ribosyltransferase activities mediate Pseudomonas aeruginosa keratitis by promoting neutrophil apoptosis and bacterial survival. J. Immunol. 188:1884-1895.
32. Suryawanshi A, et al. 2011. Role of IL-17 and Th17 cells in herpes simplex virus-induced corneal immunopathology. J. Immunol. 187:1919-1930.
33. Tabbara KF, El-Sheikh HF, Aabed B. 2000. Extended wear contact lens related bacterial keratitis. Br. J. Ophthalmol. 84:327-328.
34. Takahashi N, et al. 2008. IL-17 produced by Paneth cells drives TNFinduced shock. J. Exp. Med. 205:1755-1761.
35. Twining SS, Lohr KM, Moulder JM. 1986. The immune system in experimental Pseudomonas keratitis: model and early effects. Invest. Ophthalmol. Vis. Sci. 27:507-515.
36. Ye P, et al. 2001. Requirement of interleukin-17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense. J. Exp. Med. 194:519-527.
37. Zaidi TS, Lyczak J, Preston M, Pier GB. 1999. Cystic fibrosis transmembrane conductance regulator-mediated corneal epithelial cell ingestion of Pseudomonas aeruginosa is a key component in the pathogenesis of experimental murine keratitis. Infect. Immun. 67:1481-1492.
38. Zaidi TS, Preston MJ, Pier GB. 1997. Inhibition of bacterial adherence to host tissue does not markedly affect disease in the murine model of Pseudomonas aeruginosa corneal infection. Infect. Immun. 65:1370-1376.
39. Zaidi TS, Priebe GP, Pier GB. 2006. A live-attenuated Pseudomonas aeruginosa vaccine elicits outer membrane protein-specific active and passive protection against corneal infection. Infect. Immun. 74:975-983.
40. Zaidi TS, Zaidi T, Pier GB. 2010. Role of neutrophils, MyD88-mediated neutrophil recruitment, and complement in antibody-mediated defense against Pseudomonas aeruginosa keratitis. Invest. Ophthalmol. Vis. Sci. 51:2085-2093.