Deletion of the complement phagocytic receptors CR3 and CR4 does not alter susceptibility to experimental cerebral malaria

Parasite Immunology

Volumn 34, Issue 11, 2012, Pages 547-550

  Ramos, T N ^a   Bullard, D C ^b   Barnum, S R ^a  

^a University of Alabama at Birmingham   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

2 integrins; Cerebral malaria; Complement phagocytic receptors

Indexed keywords

COMPLEMENT PHAGOCYTIC RECEPTOR CR3; COMPLEMENT PHAGOCYTIC RECEPTOR CR4; COMPLEMENT RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN MALARIA; DISEASE COURSE; EXPERIMENTAL CEREBRAL MALARIA; INFECTION SENSITIVITY; MALE; MOUSE; NONHUMAN; PATHOGENESIS; PHAGOCYTOSIS; PRIORITY JOURNAL;

ANIMALS; DISEASE MODELS, ANIMAL; DISEASE SUSCEPTIBILITY; INTEGRIN ALPHAXBETA2; MACROPHAGE-1 ANTIGEN; MALARIA, CEREBRAL; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; SEQUENCE DELETION;

EID: 84867590154     PISSN: 01419838     EISSN: 13653024     Source Type: Journal    
DOI: 10.1111/pim.12002     Document Type: Article

References (34)

1. Spadafora C, Awandare GA, Kopydlowski KM, et al. Complement receptor 1 is a sialic acid-independent erythrocyte receptor of Plasmodium falciparum. PLoS Pathog 2010; 6: e1000968.
2. Tham WH, Wilson DW, Lopaticki S, et al. Complement receptor 1 is the host erythrocyte receptor for Plasmodium falciparum PfRh4 invasion ligand. Proc Nat Acad Sci USA 2010; 107: 17327-17332.
3. Awandare GA, Spadafora C, Moch JK, Dutta S, Haynes JD & Stoute JA. Plasmodium falciparum field isolates use complement receptor 1 (CR1) as a receptor for invasion of erythrocytes. Mol Biochem Parasitol 2011; 177: 57-60.
4. Stoute JA. Complement-regulatory proteins in severe malaria: too little or too much of a good thing? Trends Parasitol 2005; 21: 218-223.
5. Pawluczkowycz AW, Lindorfer MA, Waitumbi JN & Taylor RP. Hematin promotes complement alternative pathway-mediated deposition of C3 activation fragments on human erythrocytes: potential implications for the pathogenesis of anemia in malaria. J Immunol 2007; 179: 5543-5552.
6. Bergmann-Leitner ES, Scheiblhofer S, Weiss R, et al. C3d binding to the circumsporozoite protein carboxy-terminus deviates immunity against malaria. Int Immunol 2005; 17: 245-255.
7. Bergmann-Leitner ES, Duncan EH, Leitner WW, et al. C3d-defined complement receptor-binding peptide p28 conjugated to circumsporozoite protein provides protection against Plasmodium berghei. Vaccine 2007; 25: 7732-7736.
8. Weiss R, Gabler M, Jacobs T, Gilberger TW, Thalhamer J & Scheiblhofer S. Differential effects of C3d on the immunogenicity of gene gun vaccines encoding Plasmodium falciparum and Plasmodium berghei MSP1(42). Vaccine 2010; 28: 4515-4522.
9. Dale DC, Boxer L & Liles WC. The phagocytes: neutrophils and monocytes. Blood 2008; 112: 935-945.
10. Ricklin D, Hajishengallis G, Yang K & Lambris JD. Complement: a key system for immune surveillance and homeostasis. Nat Immunol 2010; 11: 785-797.
11. Murray PJ & Wynn TA. Protective and pathogenic functions of macrophage subsets. Nat Rev Immunol 2011; 11: 723-737.
12. Davis DM. Mechanisms and functions for the duration of intercellular contacts made by lymphocytes. Nat Rev Immunol 2009; 9: 543-555.
13. Ley K, Laudanna C, Cybulsky MI & Nourshargh S. Getting to the site of inflammation: the leukocyte adhesion cascade updated. Nat Rev Immunol 2007; 7: 678-689.
14. Luster AD, Alon R & von Andrain UH. Immune cell migration in inflammation: present and future therapeutics. Nat Immunol 2005; 6: 1182-1190.
15. Hu X, Wohler JE, Dugger KJ & Barnum SR. beta2-integrins in demyelinating disease: not adhering to the paradigm. J Leukoc Biol 2010; 87: 397-403.
16. Schwarzer E, Alessio M, Ulliers D & Arese P. Phagocytosis of the malarial pigment, hemozoin, impairs expression of major histocompatibility complex class II antigen, CD54, and CD11c in human monocytes. Infect Immun 1998; 66: 1601-1606.
17. Perry JA, Rush A, Wilson RJ, Olver CS & Avery AC. Dendritic cells from malaria-infected mice are fully functional APC. J Immunol 2004; 172: 475-482.
18. Van den Steen PE, Van Aelst I, Starckx S, Maskos K, Opdenakker G & Pagenstecher A. Matrix metalloproteinases, tissue inhibitors of MMPs and TACE in experimental cerebral malaria. Lab Invest 2006; 86: 873-888.
19. Ing R, Segura M, Thawani N, Tam M & Stevenson MM. Interaction of mouse dendritic cells and malaria-infected erythrocytes: uptake, maturation, and antigen presentation. J Immunol 2006; 176: 441-450.
20. Voisine C, Mastelic B, Sponaas AM & Langhorne J. Classical CD11c+ dendritic cells, not plasmacytoid dendritic cells, induce T cell responses to Plasmodium chabaudi malaria. Int J Parasitol 2010; 40: 711-719.
21. Falanga PB & Butcher EC. Late treatment with anti-LFA-1 (CD11a) antibody prevents cerebral malaria in a mouse model. Eur J Immunol 1991; 21: 2259-2263.
22. Grau GE, Pointaire P, Piguet PF, et al. Late administration of monoclonal antibody to leukocyte function-antigen 1 abrogates incipient murine cerebral malaria. Eur J Immunol 1991; 21: 2265-2267.
23. Lu H, Smith CW, Perrard J, et al. LFA-1 is sufficient in mediating neutrophil transmigration in Mac-1 deficient mice. J Clin Invest 1997; 99: 1340-1350.
24. Wu H, Rodgers JR, Perrard XY, et al. Deficiency of CD11b or CD11d results in reduced staphylococcal enterotoxin-induced T cell response and T cell phenotypic changes. J Immunol 2004; 173: 297-306.
25. Ramos TN, Darley M, Bilker O, et al. Cutting edge: The membrane attack complex of complement is required for the development of experimental cerebral malaria. J Immun 2011; 186: 6657-6660.
26. Sinden RE, Butcher GA & Beetsma AL. Maintenance of the Plasmodium berghei life cycle. Methods Mol Med 2002; 72: 25-40.
27. Miyazaki Y, Bunting M, Stafforini DM, et al. Integrin alphaDbeta2 is dynamically expressed by inflamed macrophages and alters the natural history of lethal systemic infections. J Immunol 2008; 180: 590-600.
28. Grau GE, Tacchini-Cottier F, Vesin C, et al. TNF-induced microvascular pathology: active role for platelets and importance of the LFA-1/ICAM-1 interaction. Eur Cytokine Netw 1993; 4: 415-419.
29. Ding ZM, Babensee JE, Simon SI, et al. Relative contribution of LFA-1 and Mac-1 to neutrophil adhesion and migration. J Immunol 1999; 163: 5029-5038.
30. Diamond MS, Staunton DE, de Fougerolles AR, et al. ICAM-1 (CD54): a counter-receptor for Mac-1 (CD11b/CD18). J Cell Biol 1990; 111: 3129-3139.
31. Diamond MS, Garcia-Aguilar J, Bickford JK, Corbi AL & Springer TA. The I domain is a major recognition site on the leukocyte integrin Mac-1 (CD11b/CD18) for four distinct adhesion ligands. J Cell Biol 1993; 120: 1031-1043.
32. Frick C, Odermatt A, Zen K, et al. Interaction of ICAM-1 with beta 2-integrin CD11c/CD18: characterization of a peptide ligand that mimics a putative binding site on domain D4 of ICAM-1. Eur J Immunol 2005; 35: 3610-3621.
33. Turner GD, Morrison H, Jones M, et al. An immunohistochemical study of the pathology of fatal malaria. Evidence for widespread endothelial activation and a potential role for intercellular adhesion molecule-1 in cerebral sequestration. Am J Pathol 1994; 145: 1057-1069.
34. Patel SN, Berghout J, Lovegrove FE, et al. C5 deficiency and C5a or C5aR blockade protects against cerebral malaria. J Exp Med 2008; 205: 1133-1143.