Antimicrobial lipopeptaibol trichogin GA IV: Role of the three Aib residues on conformation and bioactivity

Amino Acids

Volumn 43, Issue 4, 2012, Pages 1761-1777

  De Zotti, Marta ^a   Biondi, Barbara ^a   Park, Yoonkyung ^b   Hahm, Kyung Soo ^c   Crisma, Marco ^a   Toniolo, Claudio ^a   Formaggio, Fernando ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b Chosun University   (South Korea)

^c Chosun University College of Medicine   (South Korea)

Author keywords

Antibiotics; Bioactivity; C Tetrasubstituted Amino acids; Conformational analysis; Membranes; Peptides

Indexed keywords

2 AMINO 2 METHYLPROPIONIC ACID; LEUCINE; POLYPEPTIDE ANTIBIOTIC AGENT; TRICHOGIN GA IV; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA ALBICANS; CIRCULAR DICHROISM; CONTROLLED STUDY; DRUG CYTOTOXICITY; ENZYME STABILITY; ESCHERICHIA COLI; HEMOLYSIS; HUMAN; HUMAN CELL; LIPOPHILICITY; MEMBRANE PERMEABILITY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN STRUCTURE; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS; TRICHOSPORON BEIGELII; X RAY DIFFRACTION;

AMINO ACID SUBSTITUTION; AMINOISOBUTYRIC ACIDS; ANTI-INFECTIVE AGENTS; CANDIDA ALBICANS; CIRCULAR DICHROISM; ESCHERICHIA COLI; KINETICS; LEUCINE; LIPOPEPTIDES; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PSEUDOMONAS AERUGINOSA; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS; TRICHOSPORON; X-RAY DIFFRACTION;

EID: 84867579707     PISSN: 09394451     EISSN: 14382199     Source Type: Journal    
DOI: 10.1007/s00726-012-1261-7     Document Type: Article

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