A dual role for interferon γ signalling in hepatocellular carcinoma

Journal of Hepatology

Volumn 57, Issue 5, 2012, Pages 940-942

  Eferl, Robert ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; MAJOR HISTOCOMPATIBILITY ANTIGEN; STAT PROTEIN;

APOPTOSIS; AUTOIMMUNE HEPATITIS; CELL PROLIFERATION; CELL SURVIVAL; CYTOKINE PRODUCTION; DOWN REGULATION; GENE ACTIVITY; GENE MUTATION; GENE SEQUENCE; HUMAN; INNATE IMMUNITY; LIVER CARCINOGENESIS; LIVER CELL; LIVER CELL CARCINOMA; LIVER FIBROSIS; LIVER PROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION;

EID: 84867575103     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2012.07.040     Document Type: Editorial

References (20)

1. D.F. Calvisi, S. Ladu, A. Gorden, M. Farina, J.S. Lee, and E.A. Conner Mechanistic and prognostic significance of aberrant methylation in the molecular pathogenesis of human hepatocellular carcinoma J Clin Invest 117 2007 2713 2722
2. J. Hou, L. Lin, W. Zhou, Z. Wang, G. Ding, and Q. Dong Identification of miRNomes in human liver and hepatocellular carcinoma reveals miR-199a/b-3p as therapeutic target for hepatocellular carcinoma Cancer Cell 19 2011 232 243
3. P. Laurent-Puig, P. Legoix, O. Bluteau, J. Belghiti, D. Franco, and F. Binot Genetic alterations associated with hepatocellular carcinomas define distinct pathways of hepatocarcinogenesis Gastroenterology 120 2001 1763 1773
4. J.S. Lee, I.S. Chu, J. Heo, D.F. Calvisi, Z. Sun, and T. Roskams Classification and prediction of survival in hepatocellular carcinoma by gene expression profiling Hepatology 40 2004 667 676
5. S. Roessler, E.L. Long, A. Budhu, Y. Chen, X. Zhao, and J. Ji Integrative genomic identification of genes on 8p associated with hepatocellular carcinoma progression and patient survival Gastroenterology 142 2012 957 966 e912
6. J. Shen, S. Wang, Y.J. Zhang, M. Kappil, H.C. Wu, and M.G. Kibriya Genome-wide DNA methylation profiles in hepatocellular carcinoma Hepatology 55 2012 1799 1808
7. Y. Tao, J. Ruan, S.H. Yeh, X. Lu, Y. Wang, and W. Zhai Rapid growth of a hepatocellular carcinoma and the driving mutations revealed by cell-population genetic analysis of whole-genome data Proc Natl Acad Sci USA 108 2011 12042 12047
8. E.T. Sawey, M. Chanrion, C. Cai, G. Wu, J. Zhang, and L. Zender Identification of a therapeutic strategy targeting amplified FGF19 in liver cancer by oncogenomic screening Cancer Cell 19 2011 347 358
9. G.S. Feng Conflicting roles of molecules in hepatocarcinogenesis: paradigm or paradox Cancer Cell 21 2012 150 154
10. Z. Meng, X. Wang, Y. Gan, Y. Zhang, H. Zhou, and C. Van Ness Deletion of IFNγ enhances hepatocarcinogenesis in FXR knockout mice J Hepatol 57 2012 1004 1012
11. N. Liu, Z. Meng, G. Lou, W. Zhou, X. Wang, and Y. Zhang Hepatocarcinogenesis in FXR-/- mice mimics human HCC progression that operates through HNF1alpha regulation of FXR expression Mol Endocrinol 26 2011 775 785
12. F. Yang, X. Huang, T. Yi, Y. Yen, D.D. Moore, and W. Huang Spontaneous development of liver tumors in the absence of the bile acid receptor farnesoid X receptor Cancer Res 67 2007 863 867
13. C.J. Horras, C.L. Lamb, and K.A. Mitchell Regulation of hepatocyte fate by interferon-gamma Cytokine Growth Factor Rev 22 2011 35 43
14. G. He, G.Y. Yu, V. Temkin, H. Ogata, C. Kuntzen, and T. Sakurai Hepatocyte IKKbeta/NF-kappaB inhibits tumor promotion and progression by preventing oxidative stress-driven STAT3 activation Cancer Cell 17 2010 286 297
15. H. Wang, F. Lafdil, L. Wang, O. Park, S. Yin, and J. Niu Hepatoprotective versus oncogenic functions of STAT3 in liver tumorigenesis Am J Pathol 179 2011 714 724
16. E.A. Bard-Chapeau, S. Li, J. Ding, S.S. Zhang, H.H. Zhu, and F. Princen Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis Cancer Cell 19 2011 629 639
17. M. Mair, L. Blaas, C.H. Osterreicher, E. Casanova, and R. Eferl JAK-STAT signaling in hepatic fibrosis Front Biosci 17 2011 2794 2811
18. P.J. Murray The JAK-STAT signaling pathway: input and output integration J Immunol 178 2007 2623 2629
19. R. Eferl, R. Ricci, L. Kenner, R. Zenz, J.P. David, and M. Rath Liver tumor development. c-Jun antagonizes the proapoptotic activity of p53 Cell 112 2003 181 192
20. S.F. Katz, A. Lechel, A.C. Obenauf, Y. Begus-Nahrmann, J.M. Kraus, and E.M. Hoffmann Disruption of Trp53 in livers of mice induces formation of carcinomas with bilineal differentiation Gastroenterology 142 2012 1229 1239 e1223