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Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 21, 2012, Pages 6750-6755

Part II. Development of novel colchicine-derived immunosuppressants with improved pharmacokinetic properties

(6) Chang, Dong Jo a Lee, Sujin a Jang, Jaebong a Kim, Soon Ok b Kim, Wan Joo b Suh, Young Ger a

a Seoul National University (South Korea)

b Team of Biotechnology and Drug Discovery (South Korea)

Author keywords

Autoimmune disease; Colchicine; Cyclosporine A (CsA); Immunosuppressant; Mixed lymphocyte reaction (MLR); Rejection of organ transplantation

Indexed keywords

CARRAGEENAN; COLCHICINE; COLCHICINE DERIVATIVE; CYCLOSPORIN A; IMMUNOSUPPRESSIVE AGENT; ZYMOSAN;

ANIMAL CELL; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTHRITIS; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DESIGN; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG HALF LIFE; DRUG METABOLISM; DRUG POTENCY; DRUG SOLUBILITY; DRUG SYNTHESIS; IC 50; IMMUNOASSAY; IMMUNOMODULATION; IN VITRO STUDY; IN VIVO STUDY; LOCAL LYMPH NODE ASSASY; LYMPH NODE; LYMPHOCYTE PROLIFERATION; MAXIMUM PLASMA CONCENTRATION; MIXED LYMPHOCYTE REACTION; MOUSE; NONHUMAN; PAW EDEMA; PHARMACOLOGICAL PARAMETERS; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; T LYMPHOCYTE; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADMINISTRATION, ORAL; ANIMALS; ARTHRITIS; BIOLOGICAL AVAILABILITY; COLCHICINE; DISEASE MODELS, ANIMAL; IMMUNOSUPPRESSIVE AGENTS; INHIBITORY CONCENTRATION 50; MICE; MICE, INBRED BALB C; MOLECULAR STRUCTURE;

MUS;

EID: 84867573907 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.08.068 Document Type: Article

Times cited : (2)

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