Differential distribution of haematopoietic and nonhaematopoietic progenitor cells in intralesional and extralesional keloid: Do keloid scars provide a niche for nonhaematopoietic mesenchymal stem cells?

British Journal of Dermatology

Volumn 162, Issue 6, 2010, Pages 1377-1383

  Iqbal, S A ^a   Syed, F ^a   McGrouther, D A ^a,b   Paus, R ^a,c   Bayat, A ^a,b  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b WYTHENSHAWE HOSPITAL   (United Kingdom)

^c UNIVERSITY OF LÜBECK   (Germany)

Author keywords

CD34; Haematopoietic and nonhaematopoietic progenitor cells; Keloid disease; Keloid scarring; Mesenchymal stem cells; Raised dermal scarring

Indexed keywords

BETA1 INTEGRIN; CD34 ANTIGEN; HERMES ANTIGEN; MICROSOMAL AMINOPEPTIDASE; STEM CELL FACTOR RECEPTOR; THY 1 ANTIGEN;

ADOLESCENT; ADULT; ARTICLE; CELL ISOLATION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KELOID; LYMPHOCYTE SUBPOPULATION; MALE; MESENCHYMAL STEM CELL; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SENSITIVITY AND SPECIFICITY; SKIN BIOPSY;

ADULT; ANTIGENS, CD; BIOLOGICAL MARKERS; BIOPSY; FEMALE; FLUORESCENCE; HEMATOPOIETIC STEM CELLS; HUMANS; KELOID; MALE; MESENCHYMAL STEM CELLS; MIDDLE AGED; SKIN; YOUNG ADULT;

EID: 77952692488     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2010.09738.x     Document Type: Article

References (15)

1. Brown JJ, Bayat A. Genetic susceptibility to raised dermal scarring. Br J Dermatol 2009 161 : 8 18.
2. Vincent AS, Phan TT, Mukhopadhyay A et al. Human skin keloid fibroblasts display bioenergetics of cancer cells. J Invest Dermatol 2008 128 : 702 709.
3. Gerdes MJ, Yuspa SH. The contribution of epidermal stem cells to skin cancer. Stem Cell Rev 2005 1 : 225 231.
4. Gudjonsson T, Magnusson MK. Stem cell biology and the cellular pathways of carcinogenesis. APMIS 2005 113 : 922 929.
5. Jetten AM, Harvat BL. Epidermal differentiation and squamous metaplasia: from stem cell to cell death. J Dermatol 1997 24 : 711 725.
6. Lai Y, Sun Y, Skinner CM et al. Reconstitution of marrow-derived extracellular matrix ex vivo: A robust culture system for expanding large-scale highly functional human mesenchymal stem cells. Stem Cells Dev 2009 Sep 8 [Epub ahead of print].
7. Seifert O, Bayat A, Geffers R et al. Identification of unique gene expression patterns within different lesional sites of keloids. Wound Repair Regen 2008 16 : 254 265.
8. Akino K, Akita S, Yakabe A et al. Human mesenchymal stem cells may be involved in keloid pathogenesis. Int J Dermatol 2008 47 : 1112 1117.
9. Moon JH, Kwak SS, Park G et al. Isolation and characterization of multipotent human keloid-derived mesenchymal-like stem cells. Stem Cells Dev 2008 17 : 713 724.
10. Lau K, Paus R, Tiede S et al. Exploring the role of stem cells in cutaneous wound healing. Exp Dermatol 2009 18 : 921 933.
11. Aiba S, Tagami H. Inverse correlation between CD34 expression and proline-4-hydroxylase immunoreactivity on spindle cells noted in hypertrophic scars and keloids. J Cutan Pathol 1997 24 : 65 9.
12. Aiba S, Tabata N, Ishii H et al. Dermatofibrosarcoma protuberans is a unique fibrohistiocytic tumour expressing CD34. Br J Dermatol 1992 127 : 79 84.
13. Sabatini F, Petecchia L, Tavian M et al. Human bronchial fibroblasts exhibit a mesenchymal stem cell phenotype and multilineage differentiating potentialities. Lab Invest 2005 85 : 962 971.
14. Yeh J, Green LM, Jiang TX et al. Accelerated closure of skin wounds in mice deficient in the homeobox gene Msx2. Wound Repair Regen 2009 17 : 639 648.
15. Smith AN, Willis E, Chan VT et al. Mesenchymal stem cells induce dermal fibroblast responses to injury. Exp Cell Res 2010 316 : 48 54.