A new model for determining the MTD during phase-I trials in pediatric oncology

Current Topics in Medicinal Chemistry

Volumn 12, Issue 15, 2012, Pages 1660-1664

  Faivre, C ^a   Barbolosi, D ^a   Iliadis, A ^a  

^a AIX MARSEILLE UNIVERSITY   (France)

Author keywords

CRM; DLT; MCMC methods; MTD; Prior distributions; Skewed logistic; Toxicity grades

Indexed keywords

PACLITAXEL;

ADOLESCENT; ADULT; ARTICLE; BAYES THEOREM; CANCER PATIENT; CHILD; CHILDHOOD CANCER; CLINICAL ARTICLE; CONTINUAL REASSESSMENT METHOD; DRUG DOSE ESCALATION; HUMAN; INFORMATION PROCESSING; MAXIMUM TOLERATED DOSE; MEDICAL RECORD REVIEW; NEUROTOXICITY; NEUTROPENIA; PATIENT INFORMATION; PHASE 1 CLINICAL TRIAL (TOPIC); PRESCHOOL CHILD; SAMPLE SIZE; SCHOOL CHILD;

ADOLESCENT; ANTINEOPLASTIC AGENTS; CHILD; CHILD, PRESCHOOL; CLINICAL TRIALS, PHASE I AS TOPIC; HUMANS; INFANT; MAXIMUM TOLERATED DOSE; MODELS, STATISTICAL; NEOPLASMS; PACLITAXEL;

EID: 84867569377     PISSN: 15680266     EISSN: 18734294     Source Type: Journal    
DOI: 10.2174/156802612803531469     Document Type: Article

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