Curve-free and model-based continual reassessment method designs

Biometrics

Volumn 58, Issue 1, 2002, Pages 245-249

  O'Quigley, John ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Clinical trial; Curve free continual reassessment method; Dose finding; Maximum tolerated dose; Phase 1 designs

Indexed keywords

MEDICAL APPLICATIONS; SPECIFICATIONS;

CLINICAL TRIAL; CURVE-FREE CONTINUAL REASSESSMENT METHOD; DOSE FINDING; INFORMATIVE PRIORS; MAXIMUM TOLERATED DOSE; MODEL-BASED OPC; PHASE 1; PHASE 1 DESIGN; SPECIFICATION PARAMETERS; TWO STAGE DESIGNS;

BIOMETRICS;

BIOMETRY; MEDICINE;

ARTICLE; BAYES THEOREM; DOSE CALCULATION; EXPERIMENTAL DESIGN; MAXIMUM TOLERATED DOSE; METHODOLOGY; STATISTICAL MODEL;

MARTES PENNANTI;

EID: 0036185781     PISSN: 0006341X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0006-341X.2002.00245.x     Document Type: Article

References (7)

1. Curve free methods for Phase I clinical trials
2. An extension of the continual reassessment method using a preliminary up and down design in a dose finding study in cancer patients in order to investigate a greater number of dose levels
3. Dose-finding designs using continual reassessment method
4. Continual reassessment method: A likelihood approach
5. Continual reassessment method: A practical design for Phase I clinical trials in cancer
6. Consistency of continual reassessment method in dose finding studies
7. Bayesian decision procedures with applications to dose finding studies