Drugdrug interactions in the medical intensive care unit: An assessment of frequency, severity and the medications involved

International Journal of Pharmacy Practice

Volumn 20, Issue 6, 2012, Pages 402-408

  Smithburger, Pamela L ^a   Kane Gill, Sandra L ^a   Seybert, Amy L ^a  

^a PRESBYTERIAN UNIVERSITY HOSPITAL   (United States)

Author keywords

clinical decision support software; drug drug interaction; intensive care units; patient safety

Indexed keywords

ACETYLSALICYLIC ACID; ATENOLOL; CALCIUM ACETATE; CITALOPRAM; CLONIDINE; CLOPIDOGREL; COTRIMOXAZOLE; DULOXETINE; FERROUS SULFATE; FUROSEMIDE; HEPARIN; HYDROCHLOROTHIAZIDE PLUS TRIAMTERENE; INSULIN; LABETALOL; LANSOPRAZOLE; METOPROLOL; METRONIDAZOLE; MYCOPHENOLIC ACID; PANTOPRAZOLE; PAROXETINE; POTASSIUM CHLORIDE; PREDNISONE; RISPERIDONE; SERTRALINE; SIMVASTATIN; SOTALOL; UNINDEXED DRUG; VENLAFAXINE; VORICONAZOLE; WARFARIN; DRUG;

ADULT; AGED; ARTICLE; DATA BASE; DRUG MECHANISM; FEMALE; HUMAN; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; PATIENT SAFETY; PRIORITY JOURNAL; DRUG INTERACTION; FACTUAL DATABASE; HOSPITAL INFORMATION SYSTEM; MIDDLE AGED; PROSPECTIVE STUDY; SEVERITY OF ILLNESS INDEX; UNIVERSITY HOSPITAL;

ACADEMIC MEDICAL CENTERS; AGED; DATABASES, FACTUAL; DRUG INTERACTIONS; FEMALE; HUMANS; INTENSIVE CARE UNITS; MALE; MEDICAL ORDER ENTRY SYSTEMS; MIDDLE AGED; PHARMACEUTICAL PREPARATIONS; PROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX;

EID: 84867568453     PISSN: 09617671     EISSN: 20427174     Source Type: Journal    
DOI: 10.1111/j.2042-7174.2012.00221.x     Document Type: Article

References (24)

1. Moura C, et al,. Potential drug-drug interactions associated with prolonged stays in the intensive care unit: a retrospective cohort study. Clin Drug Invest 2011; 31: 309-316.
2. Plaza J, et al,. Drug interactions and adverse events induced by drugs used in an intensive care unit. Rev Med Chil 2010; 138: 452-460.
3. Kopp BJ, et al,. Medication errors and adverse drug events in an intensive care unit: direct observation approach for detection. Crit Care Med 2006; 34: 415-425.
4. Reis AM, De Bortoli Cassiani SH,. Prevelance of potential drug interactions in patients in an intensive care unit of a university hospital in Brazil. Clinics 2011; 66: 9-15.
5. Lima R, De Bortoli Cassiani SH,. Potential drug interactions in intensive care patients at a teaching hospital. Rev Lat Am Enfermagem 2009; 17: 222-227.
6. Reis AM, De Bortoli Cassiani SH,. Adverse drug events in an intensive care unit of a university hospital. Eur J Clin Pharmacol 2011; 67: 625-632.
7. Smithburger PL, et al,. A critical evaluation of clinical decision support for the detection of drug-drug interactions. Expert Opin Drug Saf 2011; 10: 871-882.
8. Braden BJ, et al,. Computerized decision support systems: implications for practice. Stud Health Technol Inform 1997; 46: 300-304.
9. Kuperman GJ, et al,. Medication-related clinical decision support in computerized provider order entry systems: a review. J Am Med Inform Assoc 2007; 14: 29-40.
10. Glassman PA, et al,. Improving recognition of drug interactions: benefits and barriers to using automated drug alerts. Med Care 2002; 40: 1161-1171.
11. Smithburger PL, et al,. Significance of drug-drug interactions in cardiac and cardiothoracic intensive care units. Drug Safety 2010; 33: 879-888.
12. Depont F, et al,. Drug-drug interactions with systemic antifungals in clinical practice. Pharmacoepidemiol Drug Saf 2007; 16: 1227-1233.
13. Devlin JW, et al,. Adverse drug events associated with the use of analgesics, sedatives, and antipsychotics in the intensive care unit. Crit Care Med 2010; 38 (Suppl.): S231-S243.
14. Freeman BD, et al,. Pharmacoepidemiology of QT-interval prolonging drug administration in critically ill patients. Pharmacoepidemiol Drug Saf 2008; 17: 971-981.
15. Thomson Reuters (Healthcare). Micromedex Healthcare Series: Interactions (updated periodically). Greenwood Village, CO: Thomson Reuters (Healthcare). www.thomsonhc.com/hcs/librarian?submit=I+have+read+the+above+notice+- +Start+MICROMEDEX (accessed 1 November 2008).
16. Up-to-date [online]. Lexi-interact online. www.uptodate.com/crlsql/ interact/frameset.jsp (accessed 1 November 2008).
17. Shah NR, et al,. Improving acceptance of computerized prescribing alerts in ambulatory care. J Am Med Inform Assoc 2006; 13: 5-11.
18. Roberts JS, et al,. Quantifying the clinical significance of drug-drug interactions: scaling pharmacists' perceptions of a common interaction classification scheme. Ann Pharmacother 1996; 30: 926-934.
19. Spina JR, et al,. Clinical relevance of automated drug alerts from the perspective of medical providers. Am J Med Qual 2005; 20: 7-14.
20. Smithburger PL, et al,. Drug-drug interactions in cardiac and cardiothoracic intensive care units: an analysis of patients in an academic medical centre in the US. Drug Saf 2010; 33: 879-888.
21. Bertsche T, et al,. Prevention of adverse drug reactions in intensive care patients by personal intervention based on an electronic clinical decision support system. Intensive Care Med 2010; 36: 665-672.
22. Teich JM, et al,. Clinical decision support in electronic prescribing: recommendations and an action plan: report of the joint clinical decision support workgroup. J Am Med Inform Assoc 2005; 12: 365-376.
23. Payne TH, et al,. Characteristics and override rates of order checks in a practitioner order entry system. Proc AMIA 2002; 602-606.
24. Van der Sijs H, et al,. Drug safety alert generation and overriding in a large Dutch university medical centre. Pharmacoepidemiol Drug Saf 2009; 18: 941-947.