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Volumn 8, Issue 8, 2012, Pages 1178-1187

DLX4 upregulates TWIST and enhances tumor migration, invasion and metastasis

Author keywords

Breast cancer; DLX4; E cadherin; Metastasis; TWIST

Indexed keywords

DLX4 PROTEIN, HUMAN; HOMEODOMAIN PROTEIN; LUCIFERASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR TWIST;

EID: 84867525665     PISSN: 14492288     EISSN: None     Source Type: Journal    
DOI: 10.7150/ijbs.4458     Document Type: Article
Times cited : (67)

References (41)
  • 1
    • 2942707848 scopus 로고    scopus 로고
    • Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis
    • Yang J, Mani SA, Donaher JL, et al. Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell 2004; 117: 927-939.
    • (2004) Cell , vol.117 , pp. 927-939
    • Yang, J.1    Mani, S.A.2    Donaher, J.L.3
  • 2
    • 84859474055 scopus 로고    scopus 로고
    • TWIST Represses Estrogen Receptor-alpha Expression by Recruiting the NuRD Protein Complex in Breast Cancer Cells
    • Fu J, Zhang L, He T, et al. TWIST Represses Estrogen Receptor-alpha Expression by Recruiting the NuRD Protein Complex in Breast Cancer Cells. Int J Biol Sci 2012; 8: 522-532.
    • (2012) Int J Biol Sci , vol.8 , pp. 522-532
    • Fu, J.1    Zhang, L.2    He, T.3
  • 3
    • 84855478714 scopus 로고    scopus 로고
    • Normal and disease-related biological functions of Twist1 and underlying molecular mechanisms
    • Qin Q, Xu Y, He T, Qin C, Xu J. Normal and disease-related biological functions of Twist1 and underlying molecular mechanisms. Cell Res 2012; 22: 90-106.
    • (2012) Cell Res , vol.22 , pp. 90-106
    • Qin, Q.1    Xu, Y.2    He, T.3    Qin, C.4    Xu, J.5
  • 4
    • 28344444026 scopus 로고    scopus 로고
    • Twist overexpression induces in vivo angiogenesis and correlates with chromosomal instability in breast cancer
    • Mironchik Y, Winnard PT, Jr., Vesuna F, et al. Twist overexpression induces in vivo angiogenesis and correlates with chromosomal instability in breast cancer. Cancer Res 2005; 65: 10801-10809.
    • (2005) Cancer Res , vol.65 , pp. 10801-10809
    • Mironchik, Y.1    Winnard Jr., P.T.2    Vesuna, F.3
  • 5
    • 39449133669 scopus 로고    scopus 로고
    • Wang LH. Regulation of cancer cell survival, migration, and invasion by Twist: AKT2 comes to interplay
    • Cheng GZ, Zhang W, Wang LH. Regulation of cancer cell survival, migration, and invasion by Twist: AKT2 comes to interplay. Cancer Res 2008; 68: 957-960.
    • (2008) Cancer Res , vol.68 , pp. 957-960
    • Cheng, G.Z.1    Zhang, W.2
  • 6
    • 79651474948 scopus 로고    scopus 로고
    • The TWIST/Mi2/NuRD protein complex and its essential role in cancer metastasis
    • Fu J, Qin L, He T, et al. The TWIST/Mi2/NuRD protein complex and its essential role in cancer metastasis. Cell Res 2011; 21: 275-289.
    • (2011) Cell Res , vol.21 , pp. 275-289
    • Fu, J.1    Qin, L.2    He, T.3
  • 7
    • 43049165453 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition generates cells with properties of stem cells
    • Mani SA, Guo W, Liao MJ, et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 2008; 133: 704-715.
    • (2008) Cell , vol.133 , pp. 704-715
    • Mani, S.A.1    Guo, W.2    Liao, M.J.3
  • 8
    • 79952499030 scopus 로고    scopus 로고
    • Twist1-induced invadopodia formation promotes tumor metastasis
    • Eckert MA, Lwin TM, Chang AT, et al. Twist1-induced invadopodia formation promotes tumor metastasis. Cancer Cell 2011; 19: 372-386.
    • (2011) Cancer Cell , vol.19 , pp. 372-386
    • Eckert, M.A.1    Lwin, T.M.2    Chang, A.T.3
  • 9
    • 0033759191 scopus 로고    scopus 로고
    • BP1, a new homeobox gene, is frequently expressed in acute leukemias
    • Haga SB, Fu S, Karp JE, et al. BP1, a new homeobox gene, is frequently expressed in acute leukemias. Leukemia 2000; 14: 1867-1875.
    • (2000) Leukemia , vol.14 , pp. 1867-1875
    • Haga, S.B.1    Fu, S.2    Karp, J.E.3
  • 10
    • 0036205323 scopus 로고    scopus 로고
    • BP1, a homeodomain-containing isoform of DLX4, represses the beta-globin gene
    • Chase MB, Fu S, Haga SB, et al. BP1, a homeodomain-containing isoform of DLX4, represses the beta-globin gene. Mol Cell Biol 2002; 22: 2505-2514.
    • (2002) Mol Cell Biol , vol.22 , pp. 2505-2514
    • Chase, M.B.1    Fu, S.2    Haga, S.B.3
  • 11
    • 77956978036 scopus 로고    scopus 로고
    • BP1 Homeoprotein Enhances Metastatic Potential in ER-negative Breast Cancer
    • Fu Y, Lian Y, Kim KS, et al. BP1 Homeoprotein Enhances Metastatic Potential in ER-negative Breast Cancer. J Cancer 2010; 1: 54-62.
    • (2010) J Cancer , vol.1 , pp. 54-62
    • Fu, Y.1    Lian, Y.2    Kim, K.S.3
  • 12
    • 34250858105 scopus 로고    scopus 로고
    • A homeobox gene related to Drosophila distal-less promotes ovarian tumorigenicity by inducing expression of vascular endothelial growth factor and fibro-blast growth factor-2
    • Hara F, Samuel S, Liu J, Rosen D, Langley RR, Naora H. A homeobox gene related to Drosophila distal-less promotes ovarian tumorigenicity by inducing expression of vascular endothelial growth factor and fibro-blast growth factor-2. Am J Pathol 2007; 170: 1594-1606.
    • (2007) Am J Pathol , vol.170 , pp. 1594-1606
    • Hara, F.1    Samuel, S.2    Liu, J.3    Rosen, D.4    Langley, R.R.5    Naora, H.6
  • 13
    • 58149175829 scopus 로고    scopus 로고
    • BP1, a ho-meoprotein, is significantly expressed in prostate adenocarcinoma and is concordant with prostatic intraepithelial neoplasia
    • Schwartz AM, Man YG, Rezaei MK, Simmens SJ, Berg PE. BP1, a ho-meoprotein, is significantly expressed in prostate adenocarcinoma and is concordant with prostatic intraepithelial neoplasia. Mod Pathol 2009; 22: 1-6.
    • (2009) Mod Pathol , vol.22 , pp. 1-6
    • Schwartz, A.M.1    Man, Y.G.2    Rezaei, M.K.3    Simmens, S.J.4    Berg, P.E.5
  • 14
    • 61449255494 scopus 로고    scopus 로고
    • BP1, a putative signature marker for inflammatory breast cancer and tumor aggressiveness
    • Man YG, Schwartz A, Levine PH, Teal C, Berg PE. BP1, a putative signature marker for inflammatory breast cancer and tumor aggressiveness. Cancer Biomark 2009; 5: 9-17.
    • (2009) Cancer Biomark , vol.5 , pp. 9-17
    • Man, Y.G.1    Schwartz, A.2    Levine, P.H.3    Teal, C.4    Berg, P.E.5
  • 16
    • 44949257965 scopus 로고    scopus 로고
    • Prognostic significance of BP1 mRNA expression level in patients with non-small cell lung cancer
    • Yu M, Wan Y, Zou Q. Prognostic significance of BP1 mRNA expression level in patients with non-small cell lung cancer. Clin Biochem 2008; 41: 824-830.
    • (2008) Clin Biochem , vol.41 , pp. 824-830
    • Yu, M.1    Wan, Y.2    Zou, Q.3
  • 17
    • 0041765813 scopus 로고    scopus 로고
    • Correlation of expression of BP1, a homeobox gene, with estrogen receptor status in breast cancer
    • Fu SW, Schwartz A, Stevenson H, et al. Correlation of expression of BP1, a homeobox gene, with estrogen receptor status in breast cancer. Breast Cancer Res 2003; 5: R82-R87.
    • (2003) Breast Cancer Res , vol.5
    • Fu, S.W.1    Schwartz, A.2    Stevenson, H.3
  • 18
    • 80054998788 scopus 로고    scopus 로고
    • Regulation of Epithelial-Mesenchymal Transition by Homeobox Gene DLX4 in JEG-3 Trophoblast Cells: A Role in Preeclampsia
    • Sun YY, Lu M, Xi XW, et al. Regulation of Epithelial-Mesenchymal Transition by Homeobox Gene DLX4 in JEG-3 Trophoblast Cells: A Role in Preeclampsia. Reprod Sci 2011; 18: 1138-1145.
    • (2011) Reprod Sci , vol.18 , pp. 1138-1145
    • Sun, Y.Y.1    Lu, M.2    Xi, X.W.3
  • 19
    • 77956961545 scopus 로고    scopus 로고
    • BP1, an isoform of DLX4 homeoprotein, negatively regulates BRCA1 in sporadic breast cancer
    • Kluk BJ, Fu Y, Formolo TA, et al. BP1, an isoform of DLX4 homeoprotein, negatively regulates BRCA1 in sporadic breast cancer. Int J Biol Sci 2011; 6: 513-524.
    • (2011) Int J Biol Sci , vol.6 , pp. 513-524
    • Kluk, B.J.1    Fu, Y.2    Formolo, T.A.3
  • 20
    • 79958776867 scopus 로고    scopus 로고
    • Homeodomain protein DLX4 counteracts key transcriptional control mechanisms of the TGF-beta cytostatic program and blocks the antiproliferative effect of TGF-beta
    • Trinh BQ, Barengo N, Naora H. Homeodomain protein DLX4 counteracts key transcriptional control mechanisms of the TGF-beta cytostatic program and blocks the antiproliferative effect of TGF-beta. Oncogene 2011; 30: 2718-2729.
    • (2011) Oncogene , vol.30 , pp. 2718-2729
    • Trinh, B.Q.1    Barengo, N.2    Naora, H.3
  • 21
    • 0027958422 scopus 로고
    • Homeobox genes: Potential candidates for the transcriptional control of the transformed and invasive phenotype
    • Castronovo V, Kusaka M, Chariot A, Gielen J, Sobel M. Homeobox genes: potential candidates for the transcriptional control of the transformed and invasive phenotype. Biochem Pharmacol 1994; 47: 137-143.
    • (1994) Biochem Pharmacol , vol.47 , pp. 137-143
    • Castronovo, V.1    Kusaka, M.2    Chariot, A.3    Gielen, J.4    Sobel, M.5
  • 22
    • 33750328319 scopus 로고    scopus 로고
    • HOXB7, a homeodomain protein, is overexpressed in breast cancer and confers epithelial-mesenchymal transition
    • Wu X, Chen H, Parker B, et al. HOXB7, a homeodomain protein, is overexpressed in breast cancer and confers epithelial-mesenchymal transition. Cancer Res 2006; 66: 9527-9534.
    • (2006) Cancer Res , vol.66 , pp. 9527-9534
    • Wu, X.1    Chen, H.2    Parker, B.3
  • 23
    • 31544476839 scopus 로고    scopus 로고
    • Deregulation of the HOXA10 homeobox gene in endometrial carcinoma: Role in epitheli-al-mesenchymal transition
    • Yoshida H, Broaddus R, Cheng W, Xie S, Naora H. Deregulation of the HOXA10 homeobox gene in endometrial carcinoma: role in epitheli-al-mesenchymal transition. Cancer Res 2006; 66: 889-897.
    • (2006) Cancer Res , vol.66 , pp. 889-897
    • Yoshida, H.1    Broaddus, R.2    Cheng, W.3    Xie, S.4    Naora, H.5
  • 24
    • 34447123918 scopus 로고    scopus 로고
    • Identification of a metastasis signature and the DLX4 homeobox protein as a regulator of metastasis by combined transcriptome approach
    • Tomida S, Yanagisawa K, Koshikawa K, et al. Identification of a metastasis signature and the DLX4 homeobox protein as a regulator of metastasis by combined transcriptome approach. Oncogene 2007; 26: 4600-4608.
    • (2007) Oncogene , vol.26 , pp. 4600-4608
    • Tomida, S.1    Yanagisawa, K.2    Koshikawa, K.3
  • 25
    • 65449156090 scopus 로고    scopus 로고
    • Deleted in breast cancer 1, a novel androgen receptor (AR) coactivator that promotes AR DNA-binding activity
    • Fu J, Jiang J, Li J, et al. Deleted in breast cancer 1, a novel androgen receptor (AR) coactivator that promotes AR DNA-binding activity. J Biol Chem 2009; 284: 6832-6840.
    • (2009) J Biol Chem , vol.284 , pp. 6832-6840
    • Fu, J.1    Jiang, J.2    Li, J.3
  • 26
    • 79651474948 scopus 로고    scopus 로고
    • The TWIST/Mi2/NuRD protein complex and its essential role in cancer metastasis
    • Fu J, Qin L, He T, et al. The TWIST/Mi2/NuRD protein complex and its essential role in cancer metastasis. Cell Res 2011; 21: 275-289.
    • (2011) Cell Res , vol.21 , pp. 275-289
    • Fu, J.1    Qin, L.2    He, T.3
  • 27
    • 34347346076 scopus 로고    scopus 로고
    • Regulation of P-TEFb elongation complex activity by CDK9 acetylation
    • Fu J, Yoon HG, Qin J, Wong J. Regulation of P-TEFb elongation complex activity by CDK9 acetylation. Mol Cell Biol 2007; 27: 4641-4651.
    • (2007) Mol Cell Biol , vol.27 , pp. 4641-4651
    • Fu, J.1    Yoon, H.G.2    Qin, J.3    Wong, J.4
  • 28
    • 65949098187 scopus 로고    scopus 로고
    • The steroid receptor coactivator-1 regulates twist expression and promotes breast cancer metastasis
    • Qin L, Liu Z, Chen H, Xu J. The steroid receptor coactivator-1 regulates twist expression and promotes breast cancer metastasis. Cancer Res 2009; 69: 3819-3827.
    • (2009) Cancer Res , vol.69 , pp. 3819-3827
    • Qin, L.1    Liu, Z.2    Chen, H.3    Xu, J.4
  • 29
    • 84863725383 scopus 로고    scopus 로고
    • Twist contributes to hormone resistance in breast cancer by downregulating estrogen receptor-alpha
    • Vesuna F, Lisok A, Kimble B, et al. Twist contributes to hormone resistance in breast cancer by downregulating estrogen receptor-alpha. Oncogene 2012;31:3323-3334.
    • (2012) Oncogene , vol.31 , pp. 3323-3334
    • Vesuna, F.1    Lisok, A.2    Kimble, B.3
  • 30
    • 79957883313 scopus 로고    scopus 로고
    • Phosphorylation of serine 68 of Twist1 by MAPKs stabilizes Twist1 protein and promotes breast cancer cell inva-siveness
    • Hong J, Zhou J, Fu J, et al. Phosphorylation of serine 68 of Twist1 by MAPKs stabilizes Twist1 protein and promotes breast cancer cell inva-siveness. Cancer Res 2011; 71: 3980-3990.
    • (2011) Cancer Res , vol.71 , pp. 3980-3990
    • Hong, J.1    Zhou, J.2    Fu, J.3
  • 31
    • 78651401992 scopus 로고    scopus 로고
    • Snail2 is an essential mediator of Twist1-induced epithelial mesenchymal transition and metastasis
    • Casas E, Kim J, Bendesky A, Ohno-Machado L, Wolfe CJ, Yang J. Snail2 is an essential mediator of Twist1-induced epithelial mesenchymal transition and metastasis. Cancer Res 2011; 71: 245-254.
    • (2011) Cancer Res , vol.71 , pp. 245-254
    • Casas, E.1    Kim, J.2    Bendesky, A.3    Ohno-Machado, L.4    Wolfe, C.J.5    Yang, J.6
  • 32
    • 67650045932 scopus 로고    scopus 로고
    • A Twist-Snail axis critical for TrkB-induced epithelial-mesenchymal transition-like transformation, anoikis resistance, and metastasis
    • Smit MA, Geiger TR, Song JY, Gitelman I, Peeper DS. A Twist-Snail axis critical for TrkB-induced epithelial-mesenchymal transition-like transformation, anoikis resistance, and metastasis. Mol Cell Biol 2009; 29: 3722-3737.
    • (2009) Mol Cell Biol , vol.29 , pp. 3722-3737
    • Smit, M.A.1    Geiger, T.R.2    Song, J.Y.3    Gitelman, I.4    Peeper, D.S.5
  • 33
    • 77957583439 scopus 로고    scopus 로고
    • Bmi1 is essential in Twist1-induced epithelial-mesenchymal transition
    • Yang MH, Hsu DS, Wang HW, et al. Bmi1 is essential in Twist1-induced epithelial-mesenchymal transition. Nat Cell Biol 2010; 12: 982-992.
    • (2010) Nat Cell Biol , vol.12 , pp. 982-992
    • Yang, M.H.1    Hsu, D.S.2    Wang, H.W.3
  • 34
    • 38349023012 scopus 로고    scopus 로고
    • Twist is a transcriptional repressor of E-cadherin gene expression in breast cancer
    • Vesuna F, van Diest P, Chen JH, Raman V. Twist is a transcriptional repressor of E-cadherin gene expression in breast cancer. Biochem Bio-phys Res Commun 2008; 367: 235-241.
    • (2008) Biochem Bio-phys Res Commun , vol.367 , pp. 235-241
    • Vesuna, F.1    van Diest, P.2    Chen, J.H.3    Raman, V.4
  • 35
    • 33947192053 scopus 로고    scopus 로고
    • Twist tran-scriptionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel
    • Cheng GZ, Chan J, Wang Q, Zhang W, Sun CD, Wang LH. Twist tran-scriptionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel. Cancer Res 2007; 67: 1979-1987.
    • (2007) Cancer Res , vol.67 , pp. 1979-1987
    • Cheng, G.Z.1    Chan, J.2    Wang, Q.3    Zhang, W.4    Sun, C.D.5    Wang, L.H.6
  • 36
    • 45849087087 scopus 로고    scopus 로고
    • Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence
    • Ansieau S, Bastid J, Doreau A, et al. Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence. Cancer Cell 2008; 14: 79-89.
    • (2008) Cancer Cell , vol.14 , pp. 79-89
    • Ansieau, S.1    Bastid, J.2    Doreau, A.3
  • 37
    • 0037462477 scopus 로고    scopus 로고
    • Twist regulates cytokine gene expression through a negative feedback loop that represses NF-kappaB activity
    • Sosic D, Richardson JA, Yu K, Ornitz DM, Olson EN. Twist regulates cytokine gene expression through a negative feedback loop that represses NF-kappaB activity. Cell 2003; 112: 169-180.
    • (2003) Cell , vol.112 , pp. 169-180
    • Sosic, D.1    Richardson, J.A.2    Yu, K.3    Ornitz, D.M.4    Olson, E.N.5
  • 38
    • 40249113328 scopus 로고    scopus 로고
    • Direct regulation of TWIST by HIF-1alpha promotes metastasis
    • Yang MH, Wu MZ, Chiou SH, et al. Direct regulation of TWIST by HIF-1alpha promotes metastasis. Nat Cell Biol 2008; 10: 295-305.
    • (2008) Nat Cell Biol , vol.10 , pp. 295-305
    • Yang, M.H.1    Wu, M.Z.2    Chiou, S.H.3
  • 39
    • 0345700653 scopus 로고    scopus 로고
    • Twist is up-regulated in response to Wnt1 and inhibits mouse mammary cell differentiation
    • Howe LR, Watanabe O, Leonard J, Brown AM. Twist is up-regulated in response to Wnt1 and inhibits mouse mammary cell differentiation. Cancer Res 2003; 63: 1906-1913.
    • (2003) Cancer Res , vol.63 , pp. 1906-1913
    • Howe, L.R.1    Watanabe, O.2    Leonard, J.3    Brown, A.M.4
  • 40
    • 61849088969 scopus 로고    scopus 로고
    • The ubiquitin ligase CHIP acts as an upstream regulator of oncogenic pathways
    • Kajiro M, Hirota R, Nakajima Y, et al. The ubiquitin ligase CHIP acts as an upstream regulator of oncogenic pathways. Nat Cell Biol 2009; 11: 312-319.
    • (2009) Nat Cell Biol , vol.11 , pp. 312-319
    • Kajiro, M.1    Hirota, R.2    Nakajima, Y.3
  • 41
    • 84870065750 scopus 로고    scopus 로고
    • Translational control of TWIST1 expression in MCF-10A cell lines recapitulating breast cancer progression
    • Epub ahead of print
    • Nairismagi ML, Vislovukh A, Meng Q,. Translational control of TWIST1 expression in MCF-10A cell lines recapitulating breast cancer progression. Oncogene 2012; [Epub ahead of print].
    • (2012) Oncogene
    • Nairismagi, M.L.1    Vislovukh, A.2    Meng, Q.3


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