Cerebral aneurysm as an exacerbating factor in stroke pathology and a therapeutic target for neuroprotection

Current Pharmaceutical Design

Volumn 18, Issue 25, 2012, Pages 3663-3669

  Tajiri, Naoki ^a   Lau, Tsz ^a   Glover, Loren E ^a   Shinozuka, Kazutaka ^a   Kaneko, Yuji ^a   van Loveren, Harry ^a   Borlongan, Cesar V ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

Aneurysm; Angiogenesis; Stem cell therapy; Stroke; Vasculogenesis

Indexed keywords

3 HYDROXY 3 METHYLGLUTARYL COENZYME A; CATHEPSIN; COLLAGEN; CYSTEINE; ELASTIN; ENZYME INHIBITOR; GELATINASE A; GELATINASE B; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEINASE; REDUCTASE INHIBITOR; SIMVASTATIN; STROMAL CELL DERIVED FACTOR 1; TISSUE PLASMINOGEN ACTIVATOR; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2;

ARTICLE; BRAIN; BRAIN ARTERY ANEURYSM; BRAIN ISCHEMIA; BRAIN TISSUE; CELL DEATH; CEREBROVASCULAR ACCIDENT; ENDOTHELIAL PROGENITOR CELL; HEMATOPOIETIC STEM CELL; HUMAN; HYPOTHESIS; NEUROPROTECTION; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; STEM CELL TRANSPLANTATION; TRANSIENT ISCHEMIC ATTACK;

HUMANS; INTRACRANIAL ANEURYSM; NEUROPROTECTIVE AGENTS; STEM CELL TRANSPLANTATION; STROKE; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84867497699     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/138161212802002724     Document Type: Article

References (93)

1. Yu SJ, Soncini M, Kaneko Y, Hess DC, Parolini O, Borlongan CV. Amnion: a potent graft source for cell therapy in stroke. Cell Transplant 2009; 18: 111-118.
2. Roger VL, Go AS, Lloyd-Jones DM, et al. Heart Disease and Stroke Statistics--2012 Update: A Report From the American Heart Association. Circulation 2012; 125: e2-e220.
3. Group Nr-PSS. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med 1995; 333: 1581-1587.
4. American Stroke Association [Webpage], Acute and Preventive Stroke Treatments: Dallas 2011.
5. Amar AP. Brain and Vascular Imaging of Acute Stroke. World Neurosurg 2011; 76: S3-S8.
6. Astrup J, Siesjo BK, Symon L. Thresholds in cerebral ischemia-the ischemic penumbra. Stroke 1981; 12: 723.
7. Osman MM, Lulic D, Glover L, et al. Cyclosporine-A as a neuroprotective agent against stroke: Its translation from laboratory research to clinical application. Neuropeptides 2011.
8. Sims NR, Anderson MF. Mitochondrial contributions to tissue damage in stroke. Neurochem int 2002; 40: 511-526.
9. Grobelny TJ. Brain aneurysms: epidemiology, treatment options, and milestones of endovascular treatment evolution. Dis Mon: DM 2011; 57: 647.
10. Seibert B, Tummala RP, Chow R, Faridar A, Mousavi SA, Divani AA. Intracranial aneurysms: review of current treatment options and outcomes. Front Neurol 2011; 2.
11. Meng H, Wang Z, Hoi Y, et al. Complex hemodynamics at the apex of an arterial bifurcation induces vascular remodeling resembling cerebral aneurysm initiation. Stroke 2007; 38: 1924-1931.
12. Rhoton AL, Jr. Anatomy of saccular aneurysms. Surg Neurol 1980; 14: 59-66.
13. Kannoth S, Iyer R, Thomas SV, et al. Intracranial infectious aneurysm: presentation, management and outcome. J Neurol Sci 2007; 256: 3-9.
14. Dubey A, Sung WS, Chen YY, et al. Traumatic intracranial aneurysm: a brief review. J Clin Neurosci 2008; 15: 609-12.
15. Drake CG, Peerless SJ. Giant fusiform intracranial aneurysms: review of 120 patients treated surgically from 1965 to 1992. J Neurosurg 1997; 87: 141-62.
16. Selviaridis P, Spiliotopoulos A, Antoniadis C, Kontopoulos V, Foroglou G. Fusiform aneurysm of the posterior cerebral artery: report of two cases. Acta Neurochir (Wien) 2002; 144: 295-9; discussion 299.
17. Yasuno K, Bakircioglu M, Low SK, et al. Common variant near the endothelin receptor type A (EDNRA) gene is associated with intracranial aneurysm risk. Proc Natl Acad Sci U S A 2011; 108: 19707-19712.
18. Akhtar MZ, Jones A, Sideso E, Sinha S, Vaidya A, Darby C. Management of a ruptured mycotic pseudo-aneurysm following pancreas-kidney transplantation. Ann Transplant 2011; 16: 122-5.
19. Asai Y, Kurimoto Y. Impending Rupture of a Blunt Trauma-Induced Left Ventricular Aneurysm: Report of a Case. Surgery Today 2007; 37: 971-973.
20. Kanematsu Y, Kanematsu M, Kurihara C, et al. Critical Roles of Macrophages in the Formation of Intracranial Aneurysm. Stroke 2011; 42: 173-178.
21. Hashimoto T, Meng H, Young WL. Intracranial aneurysms: links among inflammation, hemodynamics and vascular remodeling. Neurol Res 2006; 28: 372.
22. Boon RA, Seeger T, Heydt S, et al. MicroRNA-29 in Aortic Dilation: Implications for Aneurysm Formation Novelty and Significance. Circulation Research 2011; 109: 1115-1119.
23. Fusco MR, Harrigan MR. Cerebrovascular Dissections'ÄîA Review Part I: Spontaneous Dissections. Neurosurgery 2011; 68: 242.
24. Lucas C, Leys D. Vasodilation in spontaneous cervical artery dissection. Frontiers of neurology and neuroscience 2005; 20: 64-9.
25. Chandra A, Suliman A, Angle N. Spontaneous dissection of the carotid and vertebral arteries: the 10-year UCSD experience. Annals of vascular surgery 2007; 21: 178-185.
26. Lucas C, Moulin T, Deplanque D, Tatu L, Chavot D. Stroke patterns of internal carotid artery dissection in 40 patients. Stroke 1998; 29: 2646-2648.
27. Benninger D, Georgiadis D, Kremer C, Studer A, Nedeltchev K, Baumgartner R. Mechanism of ischemic infarct in spontaneous carotid dissection. Stroke 2004; 35: 482-485.
28. Maski KP, Sengupta S, Silvera M, Rivkin MJ. Intracranial Artery Dissection in an Adolescent With Marfan Syndrome. Pediatric neurology 2011; 45: 39-41.
29. Larrue V, Berhoune N, Massabuau P, et al. Etiologic investigation of ischemic stroke in young adults. Neurology 2011; 76: 1983.
30. Fusco MR, Harrigan MR. Cerebrovascular Dissections: A Review. Part II: Blunt Cerebrovascular Injury. Neurosurgery 2011; 68: 517.
31. Pretre R, Kursteiner K, Reverdin A, Faidutti B. Blunt carotid artery injury: devastating consequences of undetected pseudoaneurysm. The Journal of trauma 1995; 39: 1012.
32. Wolfe SQ, Mueller-Kronast N, Aziz-Sultan MA, Zauner A, Bhatia S. Extracranial carotid artery pseudoaneurysm presenting with embolic stroke in a pediatric patient. 2008.
33. Malikov S, Thomassin JM, Magnan PE, Keshelava G, Bartoli M, Branchereau A. Open surgical reconstruction of the internal carotid artery aneurysm at the base of the skull. J Vasc Surg 2010; 51: 323-329.
34. Penn DL, Komotar RJ, Sander Connolly E. Hemodynamic mechanisms underlying cerebral aneurysm pathogenesis. J Clin Neurosci 2011; 18: 1435-1438
35. Aoki T, Kataoka H, Nishimura M, Ishibashi R, Morishita R, Miyamoto S. Ets-1 promotes the progression of cerebral aneurysm by inducing the expression of MCP-1 in vascular smooth muscle cells. Gene Ther 2010; 17: 1117-1123.
36. Aoki T, Kataoka H, Ishibashi R, Nozaki K, Hashimoto N. Cathepsin B, K, and S are expressed in cerebral aneurysms and promote the progression of cerebral aneurysms. Stroke 2008; 39: 2603-2610.
37. Aoki T, Kataoka H, Ishibashi R, Nozaki K, Hashimoto N. Simvastatin suppresses the progression of experimentally induced cerebral aneurysms in rats. Stroke 2008; 39: 1276-1285.
38. Sadamasa N, Nozaki K, Hashimoto N. Disruption of gene for inducible nitric oxide synthase reduces progression of cerebral aneurysms. Stroke 2003; 34: 2980-2984.
39. Bederson JB, Awad IA, Wiebers DO, et al. Recommendations for the management of patients with unruptured intracranial aneurysms: a statement for healthcare professionals from the Stroke Council of the American Heart Association. Circulation 2000; 102: 2300-2308.
40. Kothapalli CR, Ramamurthi A. Induced elastin regeneration by chronically activated smooth muscle cells for targeted aneurysm repair. Acta biomaterialia 2010; 6: 170-178.
41. Ruigrok YM, Rinkel GJE, Wijmenga C. Genetics of intracranial aneurysms. The Lancet Neurol 2005; 4: 179-189.
42. Fukuda S, Hashimoto N, Naritomi H, et al. Prevention of rat cerebral aneurysm formation by inhibition of nitric oxide synthase. Circulation 2000; 101: 2532-2538.
43. Calviere L, Viguier A. Unruptured intracranial aneurysm as a cause of cerebral ischemia. Clin Neurol Neurosurg 2011; 113: 28-33.
44. Lieber BB, Sadasivan C. Endoluminal scaffolds for vascular reconstruction and exclusion of aneurysms from the cerebral circulation. Stroke 2010; 41: S21-S25.
45. Meschia JF. New Information on the Genetics of Stroke. Curr Neurol Neurosci Rep 2011: 1-7.
46. Park IS, Meno JR, Witt CE, et al. Subarachnoid hemorrhage model in the rat: Modification of the endovascular filament model. J Neurosci Methods 2008; 172: 195-200.
47. Cohen JE, Yitshayek E, Gomori JM, et al. Spontaneous thrombosis of cerebral aneurysms presenting with ischemic stroke. J Neurol Sci 2007; 254: 95-98.
48. Qureshi AI, Mohammad Y, Yahia AM, et al. Ischemic events associated with unruptured intracranial aneurysms: multicenter clinical study and review of the literature. Neurosurgery 2000; 46: 282.
49. Shimada T, Toyoda K, Hagiwara N, et al. Recurrent embolic stroke originating from an internal carotid aneurysm in a young adult. J Neurol Sci 2005; 232: 115-117.
50. Qureshi AI, Mohammad Y, Yahia AM, et al. Ischemic events associated with unruptured intracranial aneurysms: multicenter clinical study and review of the literature. Neurosurgery 2000; 46: 282-9; discussion 289-90.
51. Carolei A, Sacco S. Headache attributed to stroke, TIA, intracerebral haemorrhage, or vascular malformation. Handb Clin Neurol 2010; 97: 517-528.
52. Vasconcellos LP, Flores JAC, Conti MLM, Veiga JCE, Lancellotti CLP. Spontaneous thrombosis of internal carotid artery: a natural history of giant carotid cavernous aneurysms. Arquivos de Neuro-Psiquiatria 2009; 67: 278-283.
53. Rahman M, Smietana J, Hauck E, et al. Size Ratio Correlates With Intracranial Aneurysm Rupture Status. Stroke 2010; 41: 916-920.
54. Sonobe M, Yamazaki T, Yonekura M, Kikuchi H. Small unruptured intracranial aneurysm verification study. Stroke 2010; 41: 1969-1977.
55. Wong GKC, Kwan MCL, Ng RYT, Yu SCH, Poon W. Flow diverters for treatment of intracranial aneurysms: current status and ongoing clinical trials. J Clin Neurosci 2011.
56. Peattie RA, Asbury CL, Bluth EI, Riehle TJ. Steady flow in models of abdominal aortic aneurysms. Part II: Wall stresses and their implication for in vivo thrombosis and rupture. J Ultrasound Med 1996; 15: 689-696.
57. Meyers PM, Schumacher HC, Higashida RT, et al. Reporting standards for endovascular repair of saccular intracranial cerebral aneurysms. Stroke; 2009; 40: e366-79.
58. Meyers PM, Schumacher HC, Higashida RT, et al. Reporting standards for endovascular repair of saccular intracranial cerebral aneurysms. J Neurointerv Surg 2010; 2: 312-23.
59. Zhang L, Li Y, Zhang C, Chopp M, Gosiewska A, Hong K. Delayed administration of human umbilical tissue-derived cells improved neurological functional recovery in a rodent model of focal ischemia. Stroke 2011; 42: 1437-44.
60. Bogousslavsky J, Garazi S, Jeanrenaud X, Aebischer N, Van Melle G. Stroke recurrence in patients with patent foramen ovale: the Lausanne Study. Lausanne Stroke with Paradoxal Embolism Study Group. Neurology 1996; 46: 1301-5.
61. Rodrigues MC, Voltarelli J, Sanberg PR, et al. Recent progress in cell therapy for basal ganglia disorders with emphasis on menstrual blood transplantation in stroke. Neuroscience and biobehavioral reviews 2012; 36: 177-90.
62. Emerich DF, Orive G, Borlongan C. Tales of biomaterials, molecules, and cells for repairing and treating brain dysfunction. Current stem cell research & therapy 2011; 6: 171-89.
63. Antonucci I, Stuppia L, Kaneko Y, et al. Amniotic fluid as a rich source of mesenchymal stromal cells for transplantation therapy. Cell transplantation 2011; 20: 789-95.
64. Borlongan C. Bone marrow stem cell mobilization in stroke: a 'bonehead'may be good after all! Leukemia 2011; 25: 1674-1686
65. Borlongan CV, Glover LE, Tajiri N, Kaneko Y, Freeman TB. The Great Migration of Bone Marrow-Derived Stem Cells Toward the Ischemic Brain: Therapeutic Implications for Stroke and Other Neurological Disorders. Prog Neurobiol 2011; 95: 213-228.
66. Chen J, Li Y, Katakowski M, et al. Intravenous bone marrow stromal cell therapy reduces apoptosis and promotes endogenous cell proliferation after stroke in female rat. J Neurosci Res 2003; 73: 778-86.
67. Mahmood A, Lu D, Chopp M. Marrow stromal cell transplantation after traumatic brain injury promotes cellular proliferation within the brain. Neurosurgery 2004; 55: 1185-93.
68. Mahmood A, Lu D, Chopp M. Intravenous administration of marrow stromal cells (MSCs) increases the expression of growth factors in rat brain after traumatic brain injury. J Neurotrauma 2004; 21: 33-9.
69. Zhang L, Chopp M, Zhang RL, et al. Erythropoietin amplifies stroke-induced oligodendrogenesis in the rat. PloS One 2010; 5: e11016.
70. Xiong Y, Mahmood A, Chopp M. Angiogenesis, neurogenesis and brain recovery of function following injury. Curr Opin Invest Drugs 2010; 11: 298-308.
71. Chen J, Zhang ZG, Li Y, et al. Intravenous administration of human bone marrow stromal cells induces angiogenesis in the ischemic boundary zone after stroke in rats. Circulation Res 2003; 92: 692-9.
72. Zacharek A, Chen J, Cui X, et al. Angiopoietin1/Tie2 and VEGF/Flk1 induced by MSC treatment amplifies angiogenesis and vascular stabilization after stroke. J Cereb Blood Flow Metab 2007; 27: 1684-91.
73. Chen J, Zacharek A, Zhang C, et al. Endothelial nitric oxide synthase regulates brain-derived neurotrophic factor expression and neurogenesis after stroke in mice. J Neurosci 2005; 25: 2366-75.
74. Chen J, Li Y, Zhang R, et al. Combination therapy of stroke in rats with a nitric oxide donor and human bone marrow stromal cells enhances angiogenesis and neurogenesis. Brain Res 2004; 1005: 21-8.
75. Xu C, Schmidt WUH, Villringer K, et al. Vessel size imaging reveals pathological changes of microvessel density and size in acute ischemia. J Cereb Blood Flow Metab 2011; 31: 1687-1695.
76. Asahara T, Murohara T, Sullivan A, et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science 1997; 275: 964.
77. Kawamoto A, Gwon HC, Iwaguro H, Yamaguchi JI, Uchida S, Masuda H, Silver M, Ma H, Kearney M, Isner JM, Asahara T. Therapeutic potential of ex vivo expanded endothelial progenitor cells for myocardial ischemia. Circulation 2001; 103: 634-7.
78. Iwaguro H, Yamaguchi J, Kalka C, et al. Endothelial progenitor cell vascular endothelial growth factor gene transfer for vascular regeneration. Circulation 2002; 105: 732-8.
79. Asahara T, Takahashi T, Masuda H, et al. VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells. EMBO J 1999; 18: 3964-72.
80. Drukala J, Paczkowska E, Kucia M, et al. Stem Cells, Including a Population of Very Small Embryonic-Like Stem Cells, are Mobilized Into Peripheral Blood in Patients After Skin Burn Injury. Stem Cell Rev 2011; [Epub ahead of print].
81. Bogoslovsky T, Spatz M, Chaudhry A, et al. Stromal-derived factor-1[alpha] correlates with circulating endothelial progenitor cells and with acute lesion volume in stroke patients. Stroke 2011; 42: 618-25.
82. Yamaguchi J, Kusano KF, Masuo O, et al. Stromal cell-derived factor-1 effects on ex vivo expanded endothelial progenitor cell recruitment for ischemic neovascularization. Circulation 2003; 107: 1322-1328.
83. Fan Y, Shen F, Frenzel T, et al. Endothelial progenitor cell transplantation improves long-term stroke outcome in mice. Annals of neurology 2010; 67: 488-97.
84. Barkho BZ, Munoz AE, Li X, Li L, Cunningham LA, Zhao X. Endogenous Matrix Metalloproteinase (MMP)-2 and MMP-9 Promote the Differentiation and Migration of Adult Neural Progenitor Cells in Response to Chemokines. Stem Cells 2008; 26: 3139-3149.
85. Wei H, Mao Q, Liu L, et al. Changes and function of circulating endothelial progenitor cells in patients with cerebral aneurysm. J Neurosci Res 2011; 89: 1822-1828
86. Baaj AA, Agazzi S, van Loveren H. Graft selection in cerebral revascularization. Neurosurgical focus 2009; 26: E18.
87. Weil SM, van Loveren HR, Tomsick TA, Quallen BL, Tew JM, Jr. Management of inoperable cerebral aneurysms by the navigational balloon technique. Neurosurgery 1987; 21: 296-302.
88. Larson JJ, Tew JM, Jr., Tomsick TA, van Loveren HR. Treatment of aneurysms of the internal carotid artery by intravascular balloon occlusion: long-term follow-up of 58 patients. Neurosurgery 1995; 36: 26-30; discussion 30.
89. Timperman PE, Tomsick TA, Tew JM, Jr., van Loveren HR. Aneurysm formation after carotid occlusion. AJNR. Am J Neuradiol 1995; 16: 329-31.
90. Schwarting S, Litwak S, Hao W, Bahr M, Weise J, Neumann H. Hematopoietic stem cells reduce postischemic inflammation and ameliorate ischemic brain injury. Stroke 2008; 39: 2867-75.
91. Denes A, McColl BW, Leow-Dyke SF, et al. Experimental strokeinduced changes in the bone marrow reveal complex regulation of leukocyte responses. J Cereb Blood Flow Metab 2011; 31: 1036-50.
92. Dziennis S, Akiyoshi K, Subramanian S, Offner H, Hurn PD. Role of dihydrotestosterone in post-stroke peripheral immunosuppression after cerebral ischemia. Brain Behav Immun 2011; 25: 685-95.
93. Lehnardt S, Lehmann S, Kaul D, et al. Toll-like receptor 2 mediates CNS injury in focal cerebral ischemia. J Neuroimmunol 2007; 190: 28-33.