Metabolomic investigation of the anti-platelet aggregation activity of ginsenoside Rk1 reveals attenuated 12-HETE production

Journal of Proteome Research

Volumn 11, Issue 10, 2012, Pages 4939-4946

  Ju, Hyun Kyoung ^a   Lee, Jin Gyun ^a   Park, Mi Kyung ^b   Park, So Jung ^c   Lee, Chang Hoon ^b   Park, Jeong Hill ^a   Kwon, Sung Won ^a  

^a Seoul National University   (South Korea)

^b Dongguk University   (South Korea)

^c Sungkyunkwan University   (South Korea)

Author keywords

12 hydroxy 5,8,10,14 eicosatetraenoic acid; antiplatelet aggregation activity; arachidonic acid; ginsenoside Rk1; metabolomics; thromboxane B 2

Indexed keywords

12 HYDROXYICOSATETRAENOIC ACID; ACETYLSALICYLIC ACID; ARACHIDONIC ACID; GINSENOSIDE; GINSENOSIDE RK 1; ICOSANOID; THROMBOXANE B2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTICOAGULATION; ARTICLE; CALCIUM CELL LEVEL; CELL TRANSPORT; CONTROLLED STUDY; DISCRIMINANT ANALYSIS; ENZYME ACTIVITY; ENZYME INHIBITION; MALE; METABOLOME; NONHUMAN; PRIORITY JOURNAL; QUADRUPOLE MASS SPECTROMETRY; RAT; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOCYTE AGGREGATION INHIBITION; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

12-HYDROXY-5,8,10,14-EICOSATETRAENOIC ACID; ANIMALS; ARACHIDONIC ACID; ASPIRIN; BLOOD PLATELETS; CALCIUM; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; GINSENOSIDES; MALE; MEMBRANE PROTEINS; METABOLOME; METABOLOMICS; MULTIVARIATE ANALYSIS; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PRINCIPAL COMPONENT ANALYSIS; PROTEIN TRANSPORT; RATS; RATS, SPRAGUE-DAWLEY; THROMBOXANE B2;

EID: 84867463981     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr300454f     Document Type: Article

References (39)

1. Andrews, R. K.; Berndt, M. C. Platelet physiology and thrombosis Thromb. Res. 2004, 114 (5-6) 447-53
2. Jurk, K.; Kehrel, B. E. Platelets: physiology and biochemistry Semin. Thromb. Hemostasis 2005, 31 (4) 381-92
3. Nowak, J.; Murray, J.; Oates, J.; FitzGerald, G. Biochemical evidence of a chronic abnormality in platelet and vascular function in healthy individuals who smoke cigarettes Circulation 1987, 76 (1) 6-14
4. Tsukamoto, H.; Hishinuma, T.; Mikkaichi, T.; Nakamura, H.; Yamazaki, T.; Tomioka, Y.; Mizugaki, M. Simultaneous quantification of prostaglandins, isoprostane and thromboxane in cell-cultured medium using gas chromatography-mass spectrometry J. Chromatogr., B: Anal. Technol. Biomed. Life Sci. 2002, 774 (2) 205-14
5. Yue, H.; Jansen, S. A.; Strauss, K. I.; Borenstein, M. R.; Barbe, M. F.; Rossi, L. J.; Murphy, E. A liquid chromatography/mass spectrometric method for simultaneous analysis of arachidonic acid and its endogenous eicosanoid metabolites prostaglandins, dihydroxyeicosatrienoic acids, hydroxyeicosatetraenoic acids, and epoxyeicosatrienoic acids in rat brain tissue J. Pharm. Biomed. Anal. 2007, 43 (3) 1122-34
6. Liu, J.-Y.; Li, N.; Yang, J.; Li, N.; Qiu, H.; Ai, D.; Chiamvimonvat, N.; Zhu, Y.; Hammock, B. D. Metabolic profiling of murine plasma reveals an unexpected biomarker in rofecoxib-mediated cardiovascular events Proc. Natl. Acad. Sci. 2010, 107 (39) 17017-17022
7. Kaddurah-Daouk, R.; Kristal, B. S.; Weinshilboum, R. M. Metabolomics: A global biochemical approach to drug response and disease Annu. Rev. Pharmacol. 2008, 48, 653-683
8. Corona, G.; Rizzolio, F.; Giordano, A.; Toffoli, G. Pharmaco- metabolomics: An emerging "omics" tool for the personalization of anticancer treatments and identification of new valuable therapeutic targets J. Cell. Physiol. 2012, 227 (7) 2827-2831
9. Baraldi, E.; Carraro, S.; Giordano, G.; Reniero, F.; Perilongo, G.; Zacchello, F. Metabolomics: moving towards personalized medicine Ital. J. Pediatr. 2009, 35
10. Yap, I. K. S.; Li, J. V.; Saric, J.; Martin, F.-P.; Davies, H.; Wang, Y.; Wilson, I. D.; Nicholson, J. K.; Utzinger, J. r.; Marchesi, J. R.; Holmes, E. Metabonomic and Microbiological Analysis of the Dynamic Effect of Vancomycin-Induced Gut Microbiota Modification in the Mouse J. Proteome Res. 2008, 7 (9) 3718-3728
11. Kaddurah-Daouk, R. Metabolomic mapping of schizophrenic patients treated with atypical antipsychotics discloses drug-specific differences in global lipid changes Int. J. Neuropsychopharmacol. 2008, 11, 31-32
12. Lee, M.; Villegas-Estrada, A.; Celenza, G.; Boggess, B.; Toth, M.; Kreitinger, G.; Forbes, C.; Fridman, R.; Mobashery, S.; Chang, M. Metabolism of a Highly Selective Gelatinase Inhibitor Generates Active Metabolite Chem. Biol. Drug Des. 2007, 70 (5) 371-382
13. Park, J.; Rhee, D.; Lee, Y. Biological Activities and Chemistry of Saponins from Panax ginseng by C. A. Meyer Phytochem. Rev. 2005, 4 (2) 159-175
14. Kimura, Y.; Okuda, H.; Arichi, S. Effects of various ginseng saponins on 5-hydroxytryptamine release and aggregation in human platelets J. Pharm. Pharmacol. 1988, 40 (12) 838-43
15. Lee, J. G.; Lee, Y. Y.; Kim, S. Y.; Pyo, J. S.; Yun-Choi, H. S.; Park, J. H. Platelet antiaggregating activity of ginsenosides isolated from processed ginseng Pharmazie 2009, 64 (9) 602-4
16. Lee, J. G.; Lee, Y. Y.; Wu, B.; Kim, S. Y.; Lee, Y. J.; Yun-Choi, H. S.; Park, J. H. Inhibitory activity of ginsenosides isolated from processed ginseng on platelet aggregation Pharmazie 2010, 65 (7) 520-2
17. Wee, J. J.; Kim, Y. S.; Kyung, J. S.; Song, Y. B.; Do, J. H.; Kim, D. C.; Lee, S. D. Identification of Anticoagulant Components in Korean Red Ginseng J. Ginseng Res. 2010, 34 (4) 355-362
18. Kwon, S. W.; Han, S. B.; Park, I. H.; Kim, J. M.; Park, M. K.; Park, J. H. Liquid chromatographic determination of less polar ginsenosides in processed ginseng J. Chromatogr., A 2001, 921 (2) 335-9
19. Born, G. V.; Cross, M. J. The Aggregation of Blood Platelets J. Physiol. 1963, 168, 178-95
20. Lee, D. Y.; Cho, J. G.; Lee, M. K.; Lee, J. W.; Lee, Y. H.; Yang, D. C.; Baek, N. I. Discrimination of Panax ginseng Roots Cultivated in Different Areas in Korea Using HPLC-ELSD and Principal Component Analysis J. Ginseng Res. 2011, 35 (1) 31-38
21. Ozeki, Y.; Nagamura, Y.; Ito, H.; Unemi, F.; Kimura, Y.; Igawa, T.; Kambayashi, J.; Takahashi, Y.; Yoshimoto, T. An anti-platelet agent, OPC-29030, inhibits translocation of 12-lipoxygenase and 12-hydroxyeicosatetraenoic acid production in human platelets Br. J. Pharmacol. 1999, 128 (8) 1699-704
22. Croixmarie, V.; Umbdenstock, T.; Cloarec, O.; Moreau, A. l.; Pascussi, J.-M.; Boursier-Neyret, C.; Walther, B. Integrated Comparison of Drug-Related and Drug-Induced Ultra Performance Liquid Chromatography/Mass Spectrometry Metabonomic Profiles Using Human Hepatocyte Cultures Anal. Chem. 2009, 81 (15) 6061-6069
23. Hamberg, M.; Svensson, J.; Samuelsson, B. Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides Proc. Natl. Acad. Sci. U. S. A. 1975, 72 (8) 2994-8
24. Kulmacz, R. J.; Lands, W. E. Requirements for hydroperoxide by the cyclooxygenase and peroxidase activities of prostaglandin H synthase Prostaglandins 1983, 25 (4) 531-40
25. Buerkle, M. A.; Lehrer, S.; Sohn, H. Y.; Conzen, P.; Pohl, U.; Krotz, F. Selective inhibition of cyclooxygenase-2 enhances platelet adhesion in hamster arterioles in vivo Circulation 2004, 110 (14) 2053-9
26. Baba, A.; Sakuma, S.; Okamoto, H.; Inoue, T.; Iwata, H. Calcium induces membrane translocation of 12-lipoxygenase in rat platelets J. Biol. Chem. 1989, 264 (27) 15790-5
27. Kroll, M. H.; Schafer, A. I. Biochemical mechanisms of platelet activation Blood 1989, 74 (4) 1181-95
28. Needleman, P.; Turk, J.; Jakschik, B. A.; Morrison, A. R.; Lefkowith, J. B. Arachidonic acid metabolism Annu. Rev. Biochem. 1986, 55, 69-102
29. Katoh, A.; Ikeda, H.; Murohara, T.; Haramaki, N.; Ito, H.; Imaizumi, T. Platelet-derived 12-hydroxyeicosatetraenoic acid plays an important role in mediating canine coronary thrombosis by regulating platelet glycoprotein IIb/IIIa activation Circulation 1998, 98 (25) 2891-8
30. Powell, W. S.; Gravel, S.; Khanapure, S. P.; Rokach, J. Biological inactivation of 5-oxo-6,8,11,14-eicosatetraenoic acid by human platelets Blood 1999, 93 (3) 1086-96
31. Kaur, G.; Jalagadugula, G.; Mao, G.; Rao, A. K. RUNX1/core binding factor A2 regulates platelet 12-lipoxygenase gene (ALOX12): studies in human RUNX1 haplodeficiency Blood 2010, 115 (15) 3128-35
32. Sekiya, F.; Takagi, J.; Usui, T.; Kawajiri, K.; Kobayashi, Y.; Sato, F.; Saito, Y. 12S-hydroxyeicosatetraenoic acid plays a central role in the regulation of platelet activation Biochem. Biophys. Res. Commun. 1991, 179 (1) 345-51
33. Sekiya, F.; Takagi, J.; Sasaki, K.; Kawajiri, K.; Kobayashi, Y.; Sato, F.; Saito, Y. Feedback regulation of platelet function by 12S- hydroxyeicosatetraenoic acid: inhibition of arachidonic acid liberation from phospholipids Biochim. Biophys. Acta 1990, 1044 (1) 165-8
34. Aharony, D.; Smith, J. B.; Silver, M. J. Regulation of arachidonate-induced platelet aggregation by the lipoxygenase product, 12-hydroperoxyeicosatetraenoic acid Biochim. Biophys. Acta 1982, 718 (2) 193-200
35. Nyby, M. D.; Sasaki, M.; Ideguchi, Y.; Wynne, H. E.; Hori, M. T.; Berger, M. E.; Golub, M. S.; Brickman, A. S.; Tuck, M. L. Platelet lipoxygenase inhibitors attenuate thrombin- and thromboxane mimetic-induced intracellular calcium mobilization and platelet aggregation J. Pharmacol. Exp. Ther. 1996, 278 (2) 503-9
36. Jin, Y. R.; Han, X. H.; Lee, J. J.; Lim, Y.; Kim, T. J.; Yoo, H. S.; Hong, J. T.; Lee, C. K.; Yun, Y. P. Antiplatelet effect of NQ12: a possible mechanism through the arachidonic acid cascade J. Pharmacol. Sci. 2007, 105 (2) 193-200
37. Taylor, G. W.; Morris, H. R. Lipoxygenase pathways Br. Med. Bull. 1983, 39 (3) 219-22
38. Chang, W. C.; Nakao, J.; Orimo, H.; Murota, S. Effects of reduced glutathione on the 12-lipoxygenase pathways in rat platelets Biochem. J. 1982, 202 (3) 771-6
39. Fletcher-Cieutat, M.; Vanderhoek, J. Y.; Bryant, R. W.; Bailey, J. M. Aspirin enhances the sensitivity of human platelet 12-lipoxygenase to inhibition by 15-HETE, an endogenous regulator Prostaglandins, Leukotrienes Med. 1985, 18 (2) 255-9