An anti-platelet agent, OPC-29030, inhibits translocation of 12-lipoxygenase and 12-hydroxyeicosatetraenoic acid production in human platelets

British Journal of Pharmacology

Volumn 128, Issue 8, 1999, Pages 1699-1704

  Ozeki, Yasushi ^a,c   Nagamura, Yoshie ^a   Ito, Hideki ^a   Unemi, Fumiko ^a   Kimura, Yukio ^a   Igawa, Takehiro ^b   Kambayashi, Jun ichi ^b   Takahashi, Yoshitaka ^c   Yoshimoto, Tanihiro ^c  

^a OTSUKA PHARMACEUTICAL CO LTD   (Japan)

^b OTSUKA PHARMACEUTICAL DEVELOPMENT AND COMMERCIALIZATION INC   (United States)

^c KANAZAWA UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

12(S) HETE; 12 Lipoxygenase; 5(S) HETE; 5 Lipoxygenase; FLAP; OPC 29030; Platelet; Translocation

Indexed keywords

12 HYDROXYICOSATETRAENOIC ACID; 3,4 DIHYDRO 6 [3 [1 (2 METHYLPHENYL) 2 IMIDAZOLYLSULFINYL]PROPOXY] 2(1H) QUINOLINONE; 5 HYDROXYICOSATETRAENOIC ACID; ALPHA PENTYL 4 (2 QUINOLYLMETHOXY)BENZYL ALCOHOL; ANTITHROMBOCYTIC AGENT; ARACHIDONATE 12 LIPOXYGENASE; ARACHIDONATE 5 LIPOXYGENASE ACTIVATING PROTEIN; ARACHIDONIC ACID; ENZYME INHIBITOR; INDOMETACIN; THROMBIN; THROMBOXANE B2; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME BINDING; ENZYME LOCALIZATION; ERYTHROLEUKEMIA CELL; HUMAN; HUMAN CELL; MEGAKARYOCYTE; PRIORITY JOURNAL; THROMBOCYTE;

EID: 0033405514     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702976     Document Type: Article

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