The Saccharomyces cerevisiae BEM1 homologue in Neurospora crassa promotes co-ordinated cell behaviour resulting in cell fusion

Molecular Microbiology

Volumn 86, Issue 2, 2012, Pages 349-366

  Schürg, Timo ^a   Brandt, Ulrike ^a   Adis, Christian ^a   Fleißner, André ^a  

^a TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BEM1 PROTEIN; FUNGAL PROTEIN; MAK 2 PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ARTICLE; CELL CONTACT; CELL FUNCTION; CELL FUSION; CELL INTERACTION; CELL POLARITY; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVATION; FUNGAL CELL; FUNGAL DEVELOPMENT; FUNGUS GROWTH; FUNGUS HYPHAE; MEMBRANE FUSION; NEUROSPORA CRASSA; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; CELL POLARITY; FUNGAL PROTEINS; HYPHAE; NEUROSPORA CRASSA; SACCHAROMYCES CEREVISIAE PROTEINS;

FUNGI; NEUROSPORA CRASSA; SACCHAROMYCES CEREVISIAE;

EID: 84867445236     PISSN: 0950382X     EISSN: 13652958     Source Type: Journal    
DOI: 10.1111/j.1365-2958.2012.08197.x     Document Type: Article

References (50)

1. Altschul, S.F., Gish, W., Miller, W., Myers, E.W., and Lipman, D.J. (1990) Basic local alignment search tool. J Mol Biol 215: 403-410.
2. Araujo-Palomares, C.L., Richthammer, C., Seiler, S., and Castro-Longoria, E. (2011) Functional characterization and cellular dynamics of the CDC-42-RAC-CDC-24 module in Neurospora crassa PLoS ONE 6: e27148.
3. Armitage, J.P. (1999) Bacterial tactic responses. Adv Microb Physiol 41: 229-289.
4. Atkins, B.D., Yoshida, S., and Pellman, D. (2008) Symmetry breaking: scaffold plays matchmaker for polarity signaling proteins. Curr Biol 18: R1130-R1132.
5. Bistis, G.N. (1981) Chemotropic interactions between trichogynes and conidia of opposite mating-type in Neurospora crassa Mycologia 73: 959-975.
6. Brand, A., and Gow, N.A. (2009) Mechanisms of hypha orientation of fungi. Curr Opin Microbiol 12: 350-357.
7. Brockman, H.E., and De Serres, F.J. (1963) 'Sorbose toxicity' in Neurospora Am J Bot 50: 709-714.
8. Cano-Dominguez, N., Alvarez-Delfin, K., Hansberg, W., and Aguirre, J. (2008) NADPH oxidases NOX-1 and NOX-2 require the regulatory subunit NOR-1 to control cell differentiation and growth in Neurospora crassa Eukaryot Cell 7: 1352-1361.
9. Chenevert, J., Corrado, K., Bender, A., Pringle, J., and Herskowitz, I. (1992) A yeast gene (BEM1) necessary for cell polarization whose product contains two SH3 domains. Nature 356: 77-79.
10. Chenevert, J., Valtz, N., and Herskowitz, I. (1994) Identification of genes required for normal pheromone-induced cell polarization in Saccharomyces cerevisiae Genetics 136: 1287-1296.
11. Colot, H.V., Park, G., Turner, G.E., Ringelberg, C., Crew, C.M., Litvinkova, L., etal. (2006) A high-throughput gene knockout procedure for Neurospora reveals functions for multiple transcription factors. Proc Natl Acad Sci USA 103: 10352-10357.
12. Elion, E.A. (2000) Pheromone response, mating and cell biology. Curr Opin Microbiol 3: 573-581.
13. Fleißner, A., and Glass, N.L. (2007) SO, a protein involved in hyphal fusion in Neurospora crassa, localizes to septal plugs. Eukaryot Cell 6: 84-94.
14. Fleißner, A., Sarkar, S., Jacobson, D.J., Roca, M.G., Read, N.D., and Glass, N.L. (2005) The so locus is required for vegetative cell fusion and postfertilization events in Neurospora crassa Eukaryot Cell 4: 920-930.
15. Fleißner, A., Simonin, A.R., and Glass, N.L. (2008) Cell fusion in the filamentous fungus, Neurospora crassa Methods Mol Biol 475: 21-38.
16. Fleißner, A., Diamond, S., and Glass, N.L. (2009a) The Saccharomyces cerevisiae PRM1 homolog in Neurospora crassa is involved in vegetative and sexual cell fusion events but also has postfertilization functions. Genetics 181: 497-510.
17. Fleißner, A., Leeder, A.C., Roca, M.G., Read, N.D., and Glass, N.L. (2009b) Oscillatory recruitment of signaling proteins to cell tips promotes coordinated behavior during cell fusion. Proc Natl Acad Sci USA 106: 19387-19392.
18. Freitag, M., Hickey, P.C., Raju, N.B., Selker, E.U., and Read, N.D. (2004) GFP as a tool to analyze the organization, dynamics and function of nuclei and microtubules in Neurospora crassa Fungal Genet Biol 41: 897-910.
19. Frieser, S.H., Hlubek, A., Sandrock, B., and Bolker, M. (2011) Cla4 kinase triggers destruction of the Rac1-GEF Cdc24 during polarized growth in Ustilago maydis Mol Biol Cell 22: 3253-3262.
20. Fu, C., Iyer, P., Herkal, A., Abdullah, J., Stout, A., and Free, S.J. (2011) Identification and characterization of genes required for cell-to-cell fusion in Neurospora crassa Eukaryot Cell 10: 1100-1109.
21. Glass, N., and Fleißner, A. (2006) Re-wiring the network: understanding the mechanism and function of anastomosis in filamentous ascomycete fungi. In The Mycota I: Growth, Differentiation and Sexuality. Kües, U., and Fischer, R. (eds). Berlin Heidelberg: Springer, pp. 123-139.
22. Goryachev, A.B., Lichius, A., Wright, G.D., and Read, N.D. (2012) Excitable behavior can explain the 'ping-pong' mode of communication between cells using the same chemoattractant. Bioessays 34: 259-266.
23. Harris, S.D. (2006) Cell polarity in filamentous fungi: shaping the mold. Int Rev Cytol 251: 41-77.
24. Hickey, P.C., Jacobson, D., Read, N.D., and Louise Glass, N.L. (2002) Live-cell imaging of vegetative hyphal fusion in Neurospora crassa Fungal Genet Biol 37: 109-119.
25. Kao, L.R., Peterson, J., Ji, R., Bender, L., and Bender, A. (1996) Interactions between the ankyrin repeat-containing protein Akr1p and the pheromone response pathway in Saccharomyces cerevisiae Mol Cell Biol 16: 168-178.
26. Kim, H., and Borkovich, K.A. (2004) A pheromone receptor gene, pre-1, is essential for mating type-specific directional growth and fusion of trichogynes and female fertility in Neurospora crassa Mol Microbiol 52: 1781-1798.
27. Kim, H., and Borkovich, K.A. (2006) Pheromones are essential for male fertility and sufficient to direct chemotropic polarized growth of trichogynes during mating in Neurospora crassa Eukaryot Cell 5: 544-554.
28. Kim, H., Wright, S.J., Park, G., Ouyang, S., Krystofova, S., and Borkovich, K.A. (2012) Roles for receptors, pheromones, G proteins and mating type genes during sexual reproduction in Neurospora crassa Genetics 190: 1389-1404.
29. Kozubowski, L., Saito, K., Johnson, J.M., Howell, A.S., Zyla, T.R., and Lew, D.J. (2008) Symmetry-breaking polarization driven by a Cdc42p GEF-PAK complex. Curr Biol 18: 1719-1726.
30. Leeder, A.C., and Turner, G. (2008) Characterisation of Aspergillus nidulans polarisome component BemA. Fungal Genet Biol 45: 897-911.
31. Leeuw, T., Fourest-Lieuvin, A., Wu, C., Chenevert, J., Clark, K., Whiteway, M., etal. (1995) Pheromone response in yeast: association of Bem1p with proteins of the MAP kinase cascade and actin. Science 270: 1210-1213.
32. Lyons, D.M., Mahanty, S.K., Choi, K.Y., Manandhar, M., and Elion, E.A. (1996) The SH3-domain protein Bem1 coordinates mitogen-activated protein kinase cascade activation with cell cycle control in Saccharomyces cerevisiae Mol Cell Biol 16: 4095-4106.
33. Margolin, B.S., Freitag, M., and Selker, E.U. (1997) Improved plasmids for gene targeting at the his-3 locus of Neurospora crassa by electroporation. Fungal Genet Newsl 44: 34-36.
34. Matheos, D., Metodiev, M., Muller, E., Stone, D., and Rose, M.D. (2004) Pheromone-induced polarization is dependent on the Fus3p MAPK acting through the formin Bni1p. J Cell Biol 165: 99-109.
35. Pandey, A., Roca, M.G., Read, N.D., and Glass, N.L. (2004) Role of a mitogen-activated protein kinase pathway during conidial germination and hyphal fusion in Neurospora crassa Eukaryot Cell 3: 348-358.
36. Read, N.D., Lichius, A., Shoji, J.Y., and Goryachev, A.B. (2009) Self-signalling and self-fusion in filamentous fungi. Curr Opin Microbiol 12: 608-615.
37. Read, N.D., Fleißner, A., Roca, M.G., and Glass, N.L. (2010) Hyphal fusion. In Cellular and Molecular Biology of Filamentous Fungi. Borkovich, K.A., and Ebbole, D. (eds). Washington, DC: ASM Press, pp. 260-273.
38. Read, N.D., Goryachev, A.B., and Lichius, A. (2012) The mechanistic basis of self-fusion between conidial anastomosis tubes during fungal colony initiation. Fungal Biol Rev 26: 1-11.
39. Riquelme, M., Yarden, O., Bartnicki-Garcia, S., Bowman, B., Castro-Longoria, E., Free, S.J., etal. (2011) Architecture and development of the Neurospora crassa hypha - a model cell for polarized growth. Fungal Biol 115: 446-474.
40. Roca, M., Read, N.D., and Wheals, A.E. (2005a) Conidial anastomosis tubes in filamentous fungi. FEMS Microbiol Lett 249: 191-198.
41. Roca, M.G., Arlt, J., Jeffree, C.E., and Read, N.D. (2005b) Cell biology of conidial anastomosis tubes in Neurospora crassa Eukaryot Cell 4: 911-919.
42. Roca, M.G., Kuo, H.C., Lichius, A., Freitag, M., and Read, N.D. (2010) Nuclear dynamics, mitosis, and the cytoskeleton during the early stages of colony initiation in Neurospora crassa Eukaryot Cell 9: 1171-1183.
43. Roca, M.G., Weichert, M., Siegmund, U., Tudzynski, P., and Fleißner, A. (2012) Germling fusion via conidial anastomosis tubes in the grey mould Botrytis cinerea requires NADPH oxidase activity. Fungal Biol 116: 379-387.
44. Sanchez-Leon, E., Verdin, J., Freitag, M., Roberson, R.W., Bartnicki-Garcia, S., and Riquelme, M. (2011) Traffic of chitin synthase 1 (CHS-1) to the Spitzenkorper and developing septa in hyphae of Neurospora crassa: actin dependence and evidence of distinct microvesicle populations. Eukaryot Cell 10: 683-695.
45. Springer, M.L., and Yanofsky, C. (1989) A morphological and genetic analysis of conidiophore development in Neurospora crassa Genes Dev 3: 559-571.
46. Takemoto, D., Kamakura, S., Saikia, S., Becker, Y., Wrenn, R., Tanaka, A., etal. (2011) Polarity proteins Bem1 and Cdc24 are components of the filamentous fungal NADPH oxidase complex. Proc Natl Acad Sci USA 108: 2861-2866.
47. Vogel, H.J. (1956) A convenient growth medium for Neurospora Microbiol Genet Bull 13: 42-46.
48. Wedlich-Soldner, R., Wai, S.C., Schmidt, T., and Li, R. (2004) Robust cell polarity is a dynamic state established by coupling transport and GTPase signaling. J Cell Biol 166: 889-900.
49. Weijer, C.J. (2004) Dictyostelium morphogenesis. Curr Opin Genet Dev 14: 392-398.
50. Westergaard, M., and Mitchell, H.K. (1947) Neurospora V. A synthetic medium favoring sexual reproduction. Am J Bot 34: 573-577.