Oscillatory recruitment of signaling proteins to cell tips promotes coordinated behavior during cell fusion

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 46, 2009, Pages 19387-19392

  Fleissner, André ^a,b   Leeder, Abigail C ^a   Roca, M Gabriela ^c   Read, Nick D ^c   Glass, N Louise ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Chemotropism; MAPK; Neurospora

Indexed keywords

FUNGAL PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; PROTEIN SO; UNCLASSIFIED DRUG; PROTEIN HISTIDINE KINASE; PROTEIN KINASE; PROTEIN-HISTIDINE KINASE;

ARTICLE; CELL COMMUNICATION; CELL FUSION; ENZYME ACTIVITY; FUNGUS GROWTH; NEUROSPORA CRASSA; NONHUMAN; OSCILLATION; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; GENETICS; METABOLISM; PHYSIOLOGY;

FUNGI; NEUROSPORA; NEUROSPORA CRASSA;

FUNGAL PROTEINS; NEUROSPORA CRASSA; PROTEIN KINASES;

EID: 73349140226     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0907039106     Document Type: Article

References (40)

1. Abmayr SM, Zhuang S, Geisbrecht ER (2008) Myoblast fusion in Drosophila. Methods Mol Biol 475:75-97.
2. Ydenberg CA, Rose MD (2008) Yeast mating: A model system for studying cell and nuclear fusion. Methods Mol Biol 475:3-20.
3. Helming L, Gordon S (2007) The molecular basis of macrophage fusion. Immunobiol 212:785-793.
4. Vignery A (2008) Macrophage fusion: Molecular mechanisms. Methods Mol Biol 475:149-161.
5. Loomis WF (2008) cAMP oscillations during aggregation of Dictyostelium. Adv Exp Med Biol 641:39-48.
6. Alem MA, Oteef MD, Flowers TH, Douglas LJ (2006) Production of tyrosol by Candida albicans biofilms and its role in quorum sensing and biofilm development. Eukaryot Cell 5:1770-1779.
7. Hornby JM, et al. (2001) Quorum sensing in the dimorphic fungus Candida albicans is mediated by farnesol. Appl Environ Microbiol 67:2982-2992.
8. Buller AHR (1933) Researches on fungi. Vol. 5. (Longman, London) pp. 416.
9. Read ND, Fleissner A, Roca GM, Glass NL (2009) Hyphal Fusion. Cellular and Molecular Biology of Filamentous Fungi, eds Borkovich KA and Ebbole D (American Society of Microbiology) (in press).
10. Fleissner A, Simonin AR, Glass NL (2008) Cell fusion in the filamentous fungus, Neurospora crassa. Methods Mol Biol 475:21-38.
11. Roca MG, Arlt J, Jeffree CE, Read ND (2005) Cell biology of conidial anastomosis tubes in Neurospora crassa. Eukaryot Cell 4:911-919.
12. Dunlap JC, et al. (2007) Enabling a community to dissect an organism: Overview of the Neurospora functional genomics project. Adv Genet 57:49-96.
13. Pandey A, Roca MG, Read ND, Glass NL (2004) Role of a mitogen-activated protein kinase pathway during conidial germination and hyphal fusion in Neurospora crassa. Eukaryot Cell 3:348-358.
14. Maerz S, et al. (2008) The nuclear Dbf2-related kinase COT1 and the mitogen-activated protein kinases MAK1 and MAK2 genetically interact to regulate filamentous growth, hyphal fusion, and sexual development in Neurospora crassa. Genetics 179:1313-1325.
15. Chen RE, Thorner J (2007) Function and regulation in MAPK signaling pathways: Lessons learned from the yeast Saccharomyces cerevisiae. Biochim Biophys Acta 1773:1311-1340.
16. Lamson RE, Takahashi S, Winters MJ, Pryciak PM (2006) Dual role for membrane localization in yeast MAP kinase cascade activation and its contribution to signaling fidelity. Curr Biol 16:618-623.
17. Kim H, Borkovich KA (2006) Pheromones are essential for male fertility and sufficient to direct chemotropic polarized growth of trichogynes during mating in Neurospora crassa. Eukaryot Cell 5:544-554.
18. Kim H, Borkovich KA (2004) A pheromone receptor gene, pre-1, is essential for mating type-specific directional growth and fusion of trichogynes and female fertility in Neurospora crassa. Mol Microbiol 52:1781-1798.
19. Fleissner A, et al. (2005) The so locus is required for vegetative cell fusion and postfertilization events in Neurospora crassa. Eukaryot Cell 4:920-930.
20. Freitag M, Hickey PC, Raju NB, Selker EU, Read ND (2004) GFP as a tool to analyze the organization, dynamics, and function of nuclei and microtubules in Neurospora crassa. Fungal Genet Biol 41:897-910.
21. Fischer-Parton S, et al. (2000) Confocal microscopy of FM4-64 as a tool for analysing endocytosis and vesicle trafficking in living fungal hyphae. J Microsc 198:246-259.
22. Ilsley JL, Sudol M, Winder SJ (2002) The WW domain: Linking cell signaling to the membrane cytoskeleton. Cell Signal 14:183-189.
23. Fleissner A, Glass NL (2007) SO, a protein involved in hyphal fusion in Neurospora crassa, localizes to septal plugs. Eukaryot Cell 6:84-94.
24. Bishop AC, et al. (2000) A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature 407:395-401.
25. Ramos JW (2008) The regulation of extracellular signal-regulated kinase (ERK) in mammalian cells. Int J Biochem Cell Biol 40:2707-2719.
26. van Drogen F, Stucke VM, Jorritsma G, Peter M (2001) MAP kinase dynamics in response to pheromones in budding yeast. Nat Cell Biol 3:1051-1059.
27. Matheos D, Metodiev M, Muller E, Stone D, Rose MD (2004) Pheromone-induced polarization is dependent on the Fus3p MAPK acting through the formin Bni1p. J Cell Biol 165:99-109.
28. Kao S, Jaiswal RK, Kolch W, Landreth GE (2001) Identification of the mechanisms regulating the differential activation of the mapk cascade by epidermal growth factor and nerve growth factor in PC12 cells. J Biol Chem 276:18169-18177.
29. Blackwell E, Kim HJ, Stone DE (2007) The pheromone-induced nuclear accumulation of the Fus3 MAPK in yeast depends on its phosphorylation state and on Dig1 and Dig2. BMC Cell Biol 8:44.
30. Winters MJ, Lamson RE, Nakanishi H, Neiman AM, Pryciak PM (2005) A membrane binding domain in the Ste5 scaffold synergizes with Gβ-γbinding to control localization and signaling in pheromone response. Mol Cell 20:21-32.
31. Choi KY, Satterberg B, Lyons DM, Elion EA (1994) Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae. Cell 78:499-512.
32. Kays AM, Borkovich KA (2004) Severe impairment of growth and differentiation in a Neurospora crassa mutant lacking all heterotrimeric Gα proteins. Genetics 166:1229-1240.
33. Krystofova S, Borkovich KA (2005) The heterotrimeric G-protein subunits GNG-1 and GNB-1 form a Gβ-γ dimer required for normal female fertility, asexual development, and Gα protein levels in Neurospora crassa. Eukaryot Cell 4:365-378.
34. Elion EA, Satterberg B, Kranz JE (1993) FUS3 phosphorylates multiple components of the mating signal transduction cascade: Evidence for STE12 and FAR1. Mol Biol Cell 4:495-510.
35. Pokholok DK, Zeitlinger J, Hannett NM, Reynolds DB, Young RA (2006) Activated signal transduction kinases frequently occupy target genes. Science 313:533-536.
36. Li D, Bobrowicz P, Wilkinson HH, Ebbole DJ (2005) Amitogen-activated protein kinase pathway essential for mating and contributing to vegetative growth in Neurospora crassa. Genetics 170:1091-1104.
37. Fox EM, Howlett BJ (2008) Secondary metabolism: Regulation and role in fungal biology. Curr Opin Microbiol 11:481-487.
38. Köhler E (1930) Zur kenntnis der vegetativen anastomosen der pilze (II. Mitteilung). Planta 10:495-522.
39. Rasmussen CG, Morgenstein RM, Peck S, Glass NL (2008) Lack of the GTPase RHO-4 in Neurospora crassa causes a reduction in numbers and aberrant stabilization of microtubules at hyphal tips. Fungal Genet Biol 45:1027-1039.
40. Vogel HJ (1956) A convenient growth medium for Neurospora. Microbiol Genet Bull 13:42-46.