Morphological parameters of flat epithelial atypia (FEA) in stereotactic vacuum-assisted needle core biopsies do not predict the presence of malignancy on subsequent surgical excision

Virchows Archiv

Volumn 461, Issue 4, 2012, Pages 405-417

  Bianchi, Simonetta ^a   Bendinelli, Benedetta ^b   Castellano, Isabella ^c   Piubello, Quirino ^d   Renne, Giuseppe ^e   Cattani, Maria Grazia ^f   Di Stefano, Domenica ^g   Carrillo, Giovanna ^h   Laurino, Licia ⁱ   Bersiga, Alessandra ^j   Giardina, Carmela ^k   Dante, Stefania ^l   Di Loreto, Carla ^m   Quero, Carmela ⁿ   Antonacci, Concetta Maria ^o   Palli, Domenico ^b  

^a UNIVERSITY OF FLORENCE   (Italy)

^b CANCER RESEARCH AND PREVENTION INSTITUTE ISPO   (Italy)

^c UNIVERSITY OF TURIN   (Italy)

^d UNIVERSITY HOSPITAL OF VERONA   (Italy)

^e EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^f BELLARIA HOSPITAL   (Italy)

^g SAPIENZA UNIVERSITY OF ROME   (Italy)

^h CARDARELLI HOSPITAL   (Italy)

ⁱ General Hospital of Treviso   (Italy)

^j Istituti Ospitalieri di Cremona   (Italy)

^k UNIVERSITY OF BARI   (Italy)

^l Hospital of Vicenza   (Italy)

^m UNIVERSITY OF UDINE   (Italy)

ⁿ NATIONAL CANCER INSTITUTE GIOVANNI PAOLO II   (Italy)

^o UNIVERSITY OF MILAN   (Italy)

more..

Author keywords

Breast; Flat epithelial atypia; Malignancy; Stereotactic vacuum assisted needle core biopsy; Surgical excision

Indexed keywords

ADVANCED CANCER; ARTICLE; ATYPICAL DUCTAL HYPERPLASIA; BREAST CANCER; CANCER GRADING; CANCER RISK; EPITHELIUM CELL; EXCISION; FEMALE; FLAT EPITHELIAL ATYPIA; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; INTRADUCTAL CARCINOMA; INVASIVE CARCINOMA; ITALY; LOBULAR INTRAEPITHELIAL NEOPLASIA; MAMMOGRAPHY; MEDICAL DEVICE; MORPHOLOGY; NEEDLE BIOPSY; PRIORITY JOURNAL; STEREOTACTIC VACUUM ASSISTED NEEDLE CORE BIOPSY;

BIOPSY, LARGE-CORE NEEDLE; BREAST; BREAST NEOPLASMS; CARCINOMA IN SITU; CARCINOMA, DUCTAL, BREAST; EPITHELIAL CELLS; FEMALE; HUMANS; HYPERPLASIA; LOGISTIC MODELS; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; STEREOTAXIC TECHNIQUES; VACUUM;

EID: 84867405501     PISSN: 09456317     EISSN: 14322307     Source Type: Journal    
DOI: 10.1007/s00428-012-1279-y     Document Type: Article

References (34)

1. Bianchi S, Caini S, Renne G et al (2011) Positive predictive value for malignancy on surgical excision of breast lesions of uncertain malignant potential (B3) diagnosed by stereotactic vacuumassisted needle core biopsy (VANCB): a large multi-institutional study in Italy. Breast 20:264-270
2. Tavassoli FA, Hoefler H, Rosai J et al (2003) Intraductal proliferative lesions. In: Tavassoli FA, Devilee P (eds) Pathology and genetics of tumours of the breast and female genital organs. IARC, Lyon, pp 63-73
3. Monfair F (2010) Flat ductal intraepithelial neoplasia of the breast. A review of diagnostic criteria, differential diagnoses, molecular genetic findings, and clinical relevance. It is time to appreciate the Azzopardi concept. Arch Pathol Lab Med 133:879-892
4. Azzopardi JP (1979) Problems in breast pathology. Saunders, London, pp 193-203
5. Simpson PT, Gale T, Reis-Filho JS et al (2005) Columnar cell lesions of the breast: the missing link in breast cancer progression? A morphological and molecular analysis. Am J Surg Pathol 29:734-746 (Pubitemid 40734423)
6. Bombonati A, Sgroi DC (2011) The molecular pathology of breast cancer progression. J Pathol 223:307-317
7. Brogi E, Oyama T, Koerner FC (2001) Atypical cystic lobules in patients with lobular neoplasia. Int J Surg Pathol 9:201-206 (Pubitemid 32979971)
8. Abdel-Fatah TMA, Powe DG, Hodi Z et al (2007) High frequency of coexistence of columnar cell lesions, lobular neoplasia, and low grade ductal carcinoma in situ with invasive tubular carcinoma and invasive lobular carcinoma. Am J Surg Pathol 31:417-426 (Pubitemid 46673116)
9. Collins LC, Achacoso NA, Nekhlydov L et al (2007) Clinical and pathologic features of ductal carcinoma in situ associated with the presence of flat epithelial atypia: an analysis of 543 patients. Mod Pathol 20:1149-1155 (Pubitemid 47609062)
10. Leibl S, Regitnig P, Monfair F (2007) Flat epithelial atypia (DIN 1a, atypical columnar change): an underdiagnosed entity very frequently coexisting with lobular neoplasia. Histopathology 50:859-865 (Pubitemid 46850074)
11. Kunju LP, Kleer CG (2007) Significance of flat epithelial atypia on mammotome core needle biopsy: should it be excised? Hum Pathol 38:35-41 (Pubitemid 44880218)
12. Lee TYJ, MacIntosh RF, Rayson D et al (2010) Flat epithelial atypia on breast needle core biopsy: a retrospective study with clinical-pathological correlation. Breast J 16:377-383
13. Boulos FI, Dupont WD, Simpson JF et al (2008) Histologic associations and long-term cancer risk in columnar cell lesions of the breast. A retrospective cohort and a nested case-control study. Cancer 113:2415-2421
14. Aroner SA, Collins LC, Schnitt SJ et al (2010) Columnar cell lesions and subsequent breast cancer risk: a nested case-control study. Breast Cancer Res 12:R61, http://breast-cancer-research.com/content/12/4/R61
15. Verschuur-Maes AHJ, Van Deurzen CHM, Monninkhof EM et al (2012) Columnar cell lesions on breast needle biopsies: is surgical excision necessary? A systematic review. Ann Surg 255:259-265
16. Lazarus E, Mainiero MB, Schepps B et al (2006) BI-RADS lexicon for US and mammography: interobserver variability and positive predictive value. Radiology 239:385-391
17. Pinder SE, Reis-Filho JS (2007) Non-operative breast pathology: columnar cell lesions. J Clin Pathol 60:1307-1312 (Pubitemid 350247245)
18. Pinder SE, Provenzano E, Reis-Filho JS (2007) Lobular in situ neoplasia and columnar cell lesions: diagnosis in breast core biopsies and implications for management. Pathology 39:208-216 (Pubitemid 46439646)
19. Schnitt SJ, Vincent-Salomon A (2003) Columnar cell lesions of the breast. Adv Anat Pathol 10:113-124
20. Page DL Rogers LW (1992) Combined histologic and cytologic criteria for the diagnosis of mammary atypical ductal hyperplasia. Hum Pathol 23:1095-1097
21. Rosen PP, Hoda SA (2010) Breast pathology: diagnosis by needle core biopsy. Lippincott Williams & Wilkins, Philadelphia
22. Cangiarella J, Guth A, Axelrod D et al (2008) Is surgical excision necessary for the management of atypical lobular hyperplasia and lobular carcinoma in situ diagnosed on core needle biopsy? A report of 38 cases and review of the literature. Arch Pathol lab Med 32:979-983 (Pubitemid 351918705)
23. Ely KA, Carter BA, Jensen RA et al (2001) Core biopsy of the breast with atypical ductal hyperplasia. A probabilistic approach to reporting. Am J Surg Pathol 25:1017-1021 (Pubitemid 32685898)
24. Wagoner MJ, Laronga C, Acs G (2009) Extent and histologic pattern of atypical ductal hyperplasia present on core needle biopsy specimens of the breast can predict ductal carcinoma in situ in subsequent excision. Am J Clin Pathol 131:112-121
25. Martel M, Barron-Rodriquez P, Tolgay Ocal I et al (2007) Flat DIN 1 (flat epithelial atypia) on core needle biopsy: 63 cases identified retrospectively among 1751 core biopsies performed over an 8-year period (1992-1999). Virchows Arch 451:883-891 (Pubitemid 350060744)
26. Piubello Q, Parisi A, Eccher A et al (2009) Flat epithelial atypia on core needle biopsy: which is the right management? Am J Surg Pathol 33:1078-1084
27. Lavoué V, Roger CM, Poilblanc M et al (2011) Pure flat atypia (DIN 1a) on core needle biopsy: study of 60 biopsies with follow-up surgical excision. Breast Cancer Res Treat 125:121-126
28. Senetta R, Campanino PP, Mariscotti G et al (2009) Columnar cell lesions associated with breast calcifications on vacuum-assisted core biopsies: clinical, radiographic, and histological correlations. Mod Pathol 22:762-769
29. Noel JC, Buxant F, Engohan-Aloghe C (2010) Immediate surgical resection of residual microcalcifications after a diagnosis of pure flat epithelial atypia on core biopsy: a word of caution. Surg Oncol 19:243-246
30. Chivukula M, Bhargava R, Tseng G et al (2009) Clinicopathologic implications of "flat epithelial atypia" in core needle biopsy specimens of the breast. Am J Clin Pathol 131:802-808
31. Sudarshan M, Meguerditchian AN, Mesorulle B et al (2011) Flat epithelial atypia of the breast: characteristics and behaviours. Am J Surg 201:245-250
32. Rosen PP (1999) Columnar cell hyperplasia is associated with lobular carcinoma in situ and tubular carcinoma. Am J Surg Pathol 23:1561
33. Sahoo S, Recant WM (2005) Triad of columnar cell alteration, lobular carcinoma in situ, and tubular carcinoma of the breast. Breast J 11:140-142 (Pubitemid 40396784)
34. Lerwill MF (2008) Flat epithelial atypia of the breast. Arch Pathol Lab Med 132:615-621 (Pubitemid 351489615)