Columnar cell lesions associated with breast calcifications on vacuum-assisted core biopsies: Clinical, radiographic, and histological correlations

Modern Pathology

Volumn 22, Issue 6, 2009, Pages 762-769

  Senetta, Rebecca ^a   Campanino, Pier Paolo ^a   Mariscotti, Giovanna ^a   Garberoglio, Sara ^a   Daniele, Lorenzo ^a   Pennecchi, Francesca ^b   MacR, Luigia ^a   Bosco, Martino ^a   Gandini, Giovanni ^a   Sapino, Anna ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b ISTITUTO NAZIONALE DI RICERCA METROLOGICA   (Italy)

Author keywords

Calcifications; Columnar cell lesions; Flat epithelial lesion

Indexed keywords

ADULT; AGED; ARTICLE; BIOPSY; BREAST BIOPSY; BREAST CALCIFICATION; CELL DAMAGE; CLINICAL ASSESSMENT; CLINICAL STUDY; CLINICAL TRIAL; COLUMNAR EPITHELIUM; CONTROLLED STUDY; FEMALE; FOLLOW UP; HORMONE SUBSTITUTION; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MAMMOGRAPHY; PATIENT CARE; PATIENT INFORMATION; PRIORITY JOURNAL; RADIOGRAPHY; SECOND LOOK SURGERY; SINGLE BLIND PROCEDURE; TUMOR CLASSIFICATION; VACUUM ASSISTED CORE BIOPSY;

BIOPSY; BIOPSY, NEEDLE; BREAST DISEASES; CALCINOSIS; FEMALE; HUMANS; MAMMOGRAPHY; PRECANCEROUS CONDITIONS; RISK FACTORS;

EID: 67349187982     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.2009.21     Document Type: Article

References (27)

1. Schnitt SJ, Vincent-Salomon A. Columnar cell lesions of the breast. Adv Anat Pathol 2003;10:113-124.
2. American College of Radiology. Breast Imaging Reporting and Data System (BI-RADS), 4th edn. American College of Radiology: Reston, VA, 2003.
3. Fraser JL, Raza S, Chorny K, et al. Columnar alteration with prominent apical snouts and secretions: a spectrum of changes frequently present in breast biopsies performed for microcalcifications. Am J Surg Pathol 1998;22:1521-1527.
4. McLaren BK, Gobbi H, Schuyler PA, et al. Immuno-histochemical expression of estrogen receptor in enlarged lobular units with columnar alteration in benign breast biopsies: a nested case-control study. Am J Surg Pathol 2005;29:105-108.
5. Oyama T, Maluf H, Koerner F. Atypical cystic lobules: an early stage in the formation of low-grade ductal carcinoma in situ. Virchows Arch 1999;435:413-421.
6. Arpino G, Laucirica R, Elledge RM. Premalignant and in situ breast disease: biology and clinical implications. Ann Intern Med 2005;143:446-457.
7. Pinder SE, Provenzano E, Reis-Filho JS. Lobular in situ neoplasia and columnar cell lesions: diagnosis in breast core biopsies and implications for management. Pathology 2007;39:208-216.
8. Simpson PT, Gale T, Reis-Filho JS, et al. Columnar cell lesions of the breast: the missing link in breast cancer progression? A morphological and molecular analysis. Am J Surg Pathol 2005;29:734-746.
9. WHO Tavassoli FA Hoefler H, Rosai J, et al. Intraductal proliferative lesions. In: Tavassoli FA, Devilee P (eds). Pathology and Genetics of Tumours of the Breast and Female Genital Organs. IARC Press: Lyon, France, 2003, pp 63-73.
10. Tremblay G, Deschenes J, Alpert L, et al. Overexpres-sion of estrogen receptors in columnar cell change and in unfolding breast lobules. Breast J 2005;11:326-332.
11. Wood CE, Hester JM, Appt SE, et al. Estrogen effects on epithelial proliferation and benign proliferative lesions in the postmenopausal primate mammary gland. Lab Invest 2008;88:938-948.
12. Abdel-Fatah TM, Powe DG, Hodi Z, et al. High frequency of coexistence of columnar cell lesions, lobular neoplasia, and low grade ductal carcinoma in situ with invasive tubular carcinoma and invasive lobular carcinoma. Am J Surg Pathol 2007;31:417-426.
13. Moinfar F, Man YG, Bratthauer GL, et al. Genetic abnormalities in mammary ductal intraepithelial neo-plasia-flat type ('clinging ductal carcinoma in situ'): a simulator of normal mammary epithelium. Cancer 2000;88:2072-2081.
14. Pinder SE, Reis-Filho JS. Non-operative breast pathology: columnar cell lesions. J Clin Pathol 2007;60:1307-1312.
15. Martel M, Barron-Rodriguez P, Tolgay Ocal I, et al. Flat DIN 1 (flat epithelial atypia) on core needle biopsy: 63 cases identified retrospectively among 1,751 core biopsies performed over an 8-year period (1992- 1999). Virchows Arch 2007;451:883-891.
16. Perry N, Broeders M, de Wolf C, et al. European Commission. European Guidelines for Quality Assurance in Breast Cancer Screening and Diagnosis. (2006), 4th edn. Office for Official Publications of the European Communities: Luxembourg.
17. Nasser SM. Columnar cell lesions: current classification and controversies. Semin Diagn Pathol 2004;21:18-24.
18. Lee S, Mohsin SK, Mao S, et al. Hormones, receptors, and growth in hyperplastic enlarged lobular units: early potential precursors of breast cancer. Breast Cancer Res 2005;8:R6.
19. Foschini MP, Fornelli A, Peterse JL, et al. Microcalci-fications in ductal carcinoma in situ of the breast: histochemical and immunohistochemical study. Hum Pathol 1996;27:178-183.
20. Rosen PP. Columnar cell hyperplasia is associated with lobular carcinoma in situ and tubular carcinoma. Am J Surg Pathol 1999;23:1561.
21. Sahoo S, Recant WM. Triad of columnar cell alteration, lobular carcinoma in situ, and tubular carcinoma of the breast. Breast J 2005;11:140-142.
22. Leibl S, Regitnig P, Moinfar F. Flat epithelial atypia (DIN 1a, atypical columnar change): an underdiagnosed entity very frequently coexisting with lobular neoplasia. Histopathology 2007;50: 859-865.
23. Nofech-Mozes S, Holloway C, Hanna W. The role of cytokeratin 5/6 as an adjunct diagnostic tool in breast core needle biopsies. Int J Surg Pathol 2008;16:399-406.
24. Anderson E, Clarke RB. Steroid receptors and cell cycle in normal mammary epithelium. J Mammary Gland Biol Neoplasia 2004;9:3-13.
25. Gompel A, Somai S, Chaouat M, et al. Hormonal regulation of apoptosis in breast cells and tissues. Steroids 2000;65:593-598.
26. Frech MS, Halama ED, Tilli MT, et al. Deregulated estrogen receptor alpha expression in mammary epithelial cells of transgenic mice results in the development of ductal carcinoma in situ. Cancer Res 2005;65:681-685.
27. Reeves GK, Beral V, Green J, et al., Million Women Study Collaborators. Hormonal therapy for menopause and breast-cancer risk by histological type: a cohort study and meta-analysis. Lancet Oncol 2006;11:910-918.