Prostaglandin E2 suppresses poly I: C-Stimulated cytokine production via EP2 and EP3 in immortalized human corneal epithelial cells

Cornea

Volumn 31, Issue 11, 2012, Pages 1294-1298

  Ueta, Mayumi ^a,b   Matsuoka, Toshiyuki ^c   Sotozono, Chie ^a   Kinoshita, Shigeru ^a  

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^b DOSHISHA UNIVERSITY   (Japan)

^c TENRI HOSPITAL   (Japan)

Author keywords

human corneal epithelial cells; prostaglandin E receptor 2; prostaglandin E receptor 3; prostaglandin E2 (PGE2

Indexed keywords

CXCL11 CHEMOKINE; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; MESSENGER RNA; POLYINOSINIC POLYCYTIDYLIC ACID; PROSTAGLANDIN E RECEPTOR 1; PROSTAGLANDIN E RECEPTOR 2; PROSTAGLANDIN E RECEPTOR 3; PROSTAGLANDIN E RECEPTOR 4; PROSTAGLANDIN E2; RANTES;

ARTICLE; ATTENUATION; CELL IMMORTALIZATION; CORNEA EPITHELIUM; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ASSAY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

CELLS, CULTURED; CYTOKINES; DINOPROSTONE; DOWN-REGULATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITHELIUM, CORNEAL; HUMANS; POLY I-C; RECEPTORS, PROSTAGLANDIN E, EP2 SUBTYPE; RECEPTORS, PROSTAGLANDIN E, EP3 SUBTYPE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 84867404205     PISSN: 02773740     EISSN: 15364798     Source Type: Journal    
DOI: 10.1097/ICO.0b013e318242fd7c     Document Type: Article

References (14)

1. Matsuoka T, Narumiya S. Prostaglandin receptor signaling in disease. ScientificWorldJournal. 2007;7:1329-1347.
2. Alexopoulou L, Holt AC, Medzhitov R, et al. Recognition of doublestranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature. 2001;413:732-738.
3. Ueta M, Kinoshita S. Ocular surface inflammation mediated by innate immunity. Eye Contact Lens. 2010;36:269-281.
4. Ueta M, Mizushima K, Yokoi N, et al. Gene-expression analysis of polyI:C-stimulated primary human conjunctival epithelial cells. Br J Ophthalmol. 2010;94:1528-1532.
5. Kumar A, Zhang J, Yu FS. Toll-like receptor 3 agonist poly(I:C)-induced antiviral response in human corneal epithelial cells. Immunology. 2006; 117:11-21.
6. Ueta M, Kawai T, Yokoi N, et al. Contribution of IPS-1 to polyI:Cinduced cytokine production in conjunctival epithelial cells. Biochem Biophys Res Commun. 2011;404:419-423.
7. Ueta M, Matsuoka T, Narumiya S, et al. Prostaglandin E receptor subtype EP3 in conjunctival epithelium regulates late-phase reaction of experimental allergic conjunctivitis. J Allergy Clin Immunol. 2009;123:466-471.
8. Ueta M, Matsuoka T, Yokoi N, et al. Prostaglandin E2 suppresses polyinosine- polycytidylic acid (polyI:C)-stimulated cytokine production via prostaglandin E2 receptor (EP) 2 and 3 in human conjunctival epithelial cells. Br J Ophthalmol. 2011;95:859-863.
9. Takayama K, García-Cardena G, Sukhova GK, et al. Prostaglandin E2 suppresses chemokine production in human macrophages through the EP4 receptor. J Biol Chem. 2002;277:44147-44154.
10. Xu XJ, Reichner JS, Mastrofrancesco B, et al. Prostaglandin E2 suppresses lipopolysaccharide-stimulated IFN-beta production. J Immunol. 2008;180:2125-2131.
11. Shiraishi H, Yoshida H, Saeki K, et al. Prostaglandin E2 is a major soluble factor produced by stromal cells for preventing inflammatory cytokine production from dendritic cells. Int Immunol. 2008;20:1219-1229.
12. Ueta M, Hamuro J, Kiyono H, et al. Triggering of TLR3 by polyI:C in human corneal epithelial cells to induce inflammatory cytokines. Biochem Biophys Res Commun. 2005;331:285-294.
13. Ueta M, Kinoshita S. Innate immunity of the ocular surface. Brain Res Bull. 2010;81:219-228.
14. Ueta M, Sotozono C, Nakano M, et al. Association between prostaglandin E receptor 3 polymorphisms and Stevens-Johnson syndrome identified by means of a genome-wide association study. J Allergy Clin Immunol. 2010;126:1218-1225. e10.