Hepatic stellate cells are involved in the pathogenesis of acute-on-chronic liver failure (ACLF)

Virchows Archiv

Volumn 461, Issue 4, 2012, Pages 393-398

  Rastogi, Archana ^a   Bihari, Chhagan ^a   Maiwall, Rakhi ^a   Ahuja, Arvind ^a   Sharma, Manoj Kumar ^a   Kumar, Ashish ^a   Sarin, Shiv Kumar ^a  

^a INSTITUTE OF LIVER AND BILIARY SCIENCES   (India)

Author keywords

SMA; ACLF; Immunohistochemistry; K19; Progenitor cells; Stellate cells

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CYTOKERATIN 19;

ACUTE HEPATITIS; ACUTE ON CHRONIC LIVER FAILURE; ADOLESCENT; ADULT; AGED; ARTICLE; CHRONIC HEPATITIS; CORRELATION ANALYSIS; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER BIOPSY; LIVER CIRRHOSIS; LIVER TRANSPLANTATION; LIVING DONOR; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; PRIORITY JOURNAL; STELLATE CELL;

ACUTE DISEASE; ADOLESCENT; ADULT; AGED; BIOPSY; END STAGE LIVER DISEASE; FEMALE; HEPATIC STELLATE CELLS; HEPATITIS; HEPATITIS, CHRONIC; HUMANS; LIVER; LIVER CIRRHOSIS; LIVER FAILURE, ACUTE; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; YOUNG ADULT;

EID: 84867401421     PISSN: 09456317     EISSN: 14322307     Source Type: Journal    
DOI: 10.1007/s00428-012-1291-2     Document Type: Article

References (22)

1. Rastogi A, Kumar A, Sakhuja P et al (2011) Liver histology as predictor of outcome in patients with acute-on-chronic liver failure (ACLF). Virchows Arch 459(2):121-127
2. Laleman W, Verbeke L, Meersseman P et al (2011) Acute-onchronic liver failure: current concepts on definition, pathogenesis, clinical manifestations and potential therapeutic interventions. Expert Rev Gastroenterol Hepatol 5(4):523-537
3. Sancho-Bru P, Najimi M, Caruso M, Pauwelyn K, Cantz T, Forbes S, Roskams T, Ott M, Gehling U, Sokal E, Verfaillie CM, Muraca M (2009) Stem and progenitor cells for liver repopulation: can we standardize the process from bench to bedside? Gut 58:594-603
4. Sicklick JK, Li Y-X, Choi SS, Qi Y et al (2005) Role for hedgehog signaling in hepatic stellate cell activation and viability. Lab Investig 85:1368-1380 (Pubitemid 41509385)
5. Kordes C, Sawitza I, Häussinger D (2008) Canonical Wnt signaling maintains the quiescent stage of hepatic stellate cells. Biochem Biophys Res Commun 367:116-123
6. Sarin SK, Kumar A, Almeida J et al (2009) Acute on chronic liver failure (ACLF): consensus recommendations of the Asia Pacific Association for the Study of the Liver (APASL). Hepatol Int 3:269-282
7. Ishak K, Baptista A, Bianchi L et al (1995) Histological grading and staging of chronic hepatitis. J Hepatol 22:696-699
8. Fauci AS, Brauwald E, Kasper DL (2005) Harrison's principle of internal medicine, 17th ed. Amazon
9. Horwath E, Kovacs K, Ross RC (1973) Liver ultrastructure in methotrexate treatment of psoriasis. Arch Dermatol 108:427-428
10. Schmitt-Graff A, Kruger S, Bochard F et al (1991) Modulation of alpha smooth muscle actin and desmin expression in perisinusoidal cells of normal and diseased human livers. Am J Pathol 138:1233-1242
11. Geerts PD (2001) History, heterogeneity, developmental, biology, and functions of quiescent hepatic stellate cells. Sem Liver Dis 21:311-335
12. Roger KM (2007) Hepatic stellate cells and liver fibrosis. Arch Pathol Lab Med 131:1728-1734
13. Friedman SL (2008) Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Physiol Rev 88:125-172
14. Burt AD (1999) Pathobiology of hepatic stellate cells. J Gastroenterol 34:299-304 (Pubitemid 29332842)
15. Brenner DA, Waterboer T, Choi SK et al (2000) New aspects of hepatic fibrosis. J Hepatol 32 (1 Suppl):32-38 (Pubitemid 30123622)
16. Cassiman D, Libbrecht L, Desmet V et al (2002) Hepatic stellate cell/myofibroblast subpopulations in fibrotic human and rat livers. J Hepatol 36:200-209 (Pubitemid 34146426)
17. Tsukada S, Parsons CJ, Rippe RA (1996) Mechanisms of liver fibrosis. J Hepatol 25(5):677-683
18. Paku S, Schnur J, Nagy P et al (2001) Origin and structural evolution of the early proliferating oval cells in rat liver. Am J Pathol 158:1313-1323 (Pubitemid 32281295)
19. Tanaka M, Itoh T, Tanimizu N et al (2011) Liver stem/progenitor cells: their characteristics and regulatory mechanisms. J Biochem 149(3):231-239
20. Yang L, Jung Y, Omenetti A et al (2008) Fate-mapping evidence that hepatic stellate cells are epithelial progenitors in adult mouse livers. Stem Cells 26:2104-2113
21. Sawitza I, Kordes C, Reister S et al (2009) The niche of stellate cells within rat liver. Hepatology 50(5):1617-1624
22. Dechêne A, Sowa JP, Robert K et al (2010) Acute liver failure is associated with elevated liver stiffness and hepatic stellate cell activation. Hepatology 52(3):1008-1016