Outcome of in vitro fertilization in patients with proven poor ovarian responsiveness after early vs. mid-follicular LH exposure: A prospective, randomized, controlled study

Journal of Assisted Reproduction and Genetics

Volumn 29, Issue 9, 2012, Pages 869-875

  Revelli, Alberto ^a   Chiado', Alessandra ^a   Guidetti, Daniela ^b   Bongioanni, Francesca ^b   Rovei, Valentina ^a   Gennarelli, Gianluca ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b LIVET Infertility   (Italy)

Author keywords

Follicle stimulation hormone; In vitro fertilization; Luteinizing hormone; Ovarian sensitivity index; Ovarian stimulation; Poor ovarian responsiveness

Indexed keywords

LUTEINIZING HORMONE; RECOMBINANT FOLLITROPIN; RECOMBINANT LUTEINIZING HORMONE;

ADULT; ARTICLE; CONTROLLED STUDY; EMBRYO TRANSFER; FEMALE; FERTILIZATION IN VITRO; HUMAN; MAJOR CLINICAL STUDY; NAUSEA; OOCYTE RETRIEVAL; OVARY DISEASE; OVULATION INDUCTION; POOR OVARIAN RESPONSIVENESS; PREGNANCY RATE; PRIORITY JOURNAL; PROSPECTIVE STUDY; SIDE EFFECT; VAGINA BLEEDING; VAGINAL DISCOMFORT; WEIGHT GAIN;

ADULT; EMBRYO TRANSFER; EMBRYO, MAMMALIAN; FEMALE; FERTILIZATION IN VITRO; FOLLICLE STIMULATING HORMONE; GONADOTROPIN-RELEASING HORMONE; HUMAN GROWTH HORMONE; HUMANS; LUTEINIZING HORMONE; OOCYTE RETRIEVAL; OVARY; OVULATION INDUCTION; PREGNANCY; PREGNANCY OUTCOME; PREGNANCY RATE; PROSPECTIVE STUDIES; RECOMBINANT PROTEINS; TREATMENT OUTCOME;

EID: 84867398350     PISSN: 10580468     EISSN: 15737330     Source Type: Journal    
DOI: 10.1007/s10815-012-9804-0     Document Type: Article

References (26)

1. Filicori M, Cognigni GE, Gamberini E, Parmegiani L, Troilo E, Roset B. Efficacy of low-dose human chorionic gonadotropin alone to complete controlled ovarian stimulation. Fertil Steril. 2005;84:394-401.
2. Durnerin CI, Erb K, Fleming R, Hillier H, Hillier SG, Howles CM, Hugues JN, Lass A, Lyall H, Rasmussen P, Thong J, Traynor I, Westergaard L, Yates R, Luveris Pretreatment Group. Effects of recombinant LH treatment on folliculogenesis and responsiveness to FSH stimulation. Hum Reprod. 2008;23:421-6.
3. Filicori M, Cognigni GE, Samara A, Melappioni S, Perri T, Cantelli B, Parmegiani L, Pelusi G, DeAloysio D. The use of LH activity to drive folliculogenesis: exploring uncharted territories in ovulation induction. Hum Reprod Update. 2002;8:543-57.
4. Hugues JN, Soussis J, Calderon I, Balasch J, Anderson RA, Romeu A, Recombinant LH Study Group. Does the addition of recombinant LH in WHO group II anovulatory women overresponding to FSH treatment reduce the number of developing follicles? A dose-finding study. Hum Reprod. 2005;20:629-35.
5. Platteau P, Nyboe Andersen A, Loft A, Smitz J, Danglas P, Devroey P. Highly purified HMG versus recombinant FSH for ovarian stimulation in IVF cycles. Reprod Biomed Online. 2008;17:190-8.
6. Al-Inany HG, Abou-Setta AM, Aboulghar MA, Mansour RT, Serour GI. Efficacy and safety of human menopausal gonadotrophins versus recombinant FSH: a meta-analysis. Reprod Biomed Online. 2008;16:81-8.
7. Weghofer A, Munné S, Brannath W, Chen S, Tomkin G, Cekleniak N, Garrisi M, Barad D, Cohen J, Gleicher N. The impact of LHcontaining gonadotropins on diploidy rates in preimplantation embryos: long protocol stimulation. Hum Reprod. 2008;23:499-503.
8. Kim YJ, Ku SY, Jee BC, Suh CS, Kim SH, Choi YM, Kim JG, Moon SY. Tri-pronucleated zygotes may occur less frequently in luteinizing hormone activity-added cycles. Gynecol Endocrinol. 2011;27:458-63.
9. Pacchiarotti A, Sbracia M, Frega A, Selman H, Rinaldi L, Pacchiarotti A. Urinary hMG (Meropur) versus recombinant FSH plus recombinant LH (Pergoveris) in IVF: a multicenter, prospective, randomized controlled trial. Fertil Steril. 2010;94:2467-9.
10. Mochtar MH, Van der Veen, Ziech M, van Wely M. Recombinant Luteinizing Hormone (rLH) for controlled ovarian hyperstimulation in assisted reproductive cycles. Cochrane Database Syst Rev. 2007; (2): CD005070.
11. Kolibianakis EM, Kalogeropoulou L, Griesinger G, Papanikolaou EG, Papadimas J, Bontis J, Tarlatzis BC. Among patients treated with FSH and GnRH analogues for in vitro fertilization, is the addition of recombinant LH associated with the probability of live birth? A systematic review and meta-analysis. Hum Reprod Update. 2007;13:445-52.
12. Fábregues F, Creus M, Peñarrubia J, Manau D, Vanrell JA, Balasch J. Effects of recombinant human luteinizing hormone supplementation on ovarian stimulation and the implantation rate in downregulated women of advanced reproductive age. Fertil Steril. 2006;85:925-31.
13. Berkkanoglu M, Isikoglu M, Aydin D, Ozgur K. Clinical effects of ovulation induction with recombinant follicle-stimulating hormone supplemented with recombinant luteinizing hormone or low-dose recombinant human chorionic gonadotropin in the midfollicular phase in microdose cycles in poor responders. Fertil Steril. 2007;88:665-9.
14. Barrenetxea G, Agirregoikoa JA, Jiménez MR, de Larruzea AL, Ganzabal T, Carbonero K. Ovarian response and pregnancy outcome in poor-responder women: a randomized controlled trial on the effect of luteinizing hormone supplementation on in vitro fertilization cycles. Fertil Steril. 2008;89:546-53.
15. Franco Jr JG, Baruffi RL, Oliveira JB, Mauri AL, Petersen CG, Contart P, Felipe V. Effects of recombinant LH supplementation to recombinant FSH during induced ovarian stimulation in the GnRH-agonist protocol: a matched case-control study. Reprod Biol Endocrinol. 2009;7:58-63.
16. Maguire M, Csokmay J, Segars J, Payson M, Armstrong A. Enough is enough! Patients who do not conceive on 600 IU/d of gonadotropins show no improvement from an additional 150 IU of LH activity. Fertil Steril. 2011;95:372-3.
17. Bosch E, Labarta E, Crespo J, Simón C, Remohí J, Pellicer A. Impact of luteinizing hormone administration on gonadotropinreleasing hormone antagonist cycles: an age-adjusted analysis. Fertil Steril. 2011;95:1031-6.
18. Kolibianakis EM, Albano C, Kahn J, Camus M, Tournaye H, Van Steirteghem AC, Devroey P. Exposure to high levels of luteinizing hormone and estradiol in the early follicular phase of gonadotropinreleasing hormone antagonist cycles is associated with a reduced chance of pregnancy. Fertil Steril. 2003;79:873-80.
19. Lahoud R, Al-Jefout M, Tyler J, Ryan J, Driscoll G. A relative reduction in mid-follicular LH concentrations during GnRH agonist IVF/ICSI cycles leads to lower live birth rates. Hum Reprod. 2006;21:2645-9.
20. Sönmezer M, Iltemir Duvan C, Ozmen B, Tapçi T, Ozkavukçu S, Atabekoolu CS. Outcomes after early or midfollicular phase LH supplementation in previous inadequate responders. Reprod Biomed Online. 2010;20:350-7.
21. Biasoni V, Patriarca A, Dalmasso P, Bertagna A, Manieri C, Benedetto C, Revelli A. Ovarian sensitivity index is strongly related to circulating AMH and may be used to predict ovarian response to exogenous gonadotropins in IVF. Reprod Biol Endocrinol. 2011;9:112-8.
22. Hillier SG. Gonadotropic control of ovarian follicular growth and development. Mol Cell Endocrinol. 2001;179:39-46.
23. Kovacs P, Kovats T, Kaali SG. Results with early follicular phase recombinant luteinizing hormone supplementation during stimulation for in vitro fertilization. Fertil Steril. 2010;93:475-9.
24. Gutman G, Barak V, Maslovitz S, Amit A, Lessing JB, Geva E. Recombinant luteinizing hormone induces increased production of ovarian follicular adiponectin in vivo: implications for enhanced insulin sensitivity. Fertil Steril. 2009;91:1837-41.
25. Yanaihara A, Yorimitsu T, Motoyama H, Ohara M, Kawamura T. The decrease of serum luteinizing hormone level by a gonadotropinreleasing hormone antagonist following the mild IVF stimulation protocol for IVF and its clinical outcome. J Assist Reprod Genet. 2008;25:115-8.
26. De Placido G, Alviggi C, Perino A, Strina I, Lisi F, Fasolino A, De Palo R, Ranieri A, Colacurci N, Mollo A, Italian Collaborative Group on Recombinant Human Luteinizing Hormone. Recombinant human LH supplementation versus recombinant human FSH (rFSH) step-up protocol during controlled ovarian stimulation in normogonadotrophic women with initial inadequate ovarian response to rFSH. A multicentre, prospective, randomized controlled trial. Hum Reprod. 2005;20:390-6.