Recombinant human LH supplementation versus recombinant human FSH (rFSH) step-up protocol during controlled ovarian stimulation in normogonadotrophic women with initial inadequate ovarian response to rFSH. A multicentre, prospective, randomized controlled trial

Human Reproduction

Volumn 20, Issue 2, 2005, Pages 390-396

  De Placido, G ^a   Alviggi, C ^a,f   Perino, A ^b   Strina, I ^a   Lisi, F ^c   Fasolino, A ^d   De Palo, R ^e   Ranieri, A ^a   Colacurci, N ^a   Mollo, A ^a   Abate, Antonino ^g   Abate, Francesco ^g   Perino, Maria ^g   Alviggi, Erminia ^a   Bertocci, Francesco ^a   Conforti, Salvatore ^a   Clarizia, Roberto ^a   D'Uva, Maristella ^a   Fiore, Emmanuel ^a   Granata, Pasquale ^a   Pagano, Tiziana ^a   Varricchio, Maria Teresa ^a   Schillaci, Rosaria ^b   Fishel, Simon ^c   Rinaldi, Leonardo ^c   Capotorto, Mariateresa ^e   Selvaggi, Luigi ^e   Mele, Daniela ^a   Tassou, Argyro ^a   more..

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF PALERMO   (Italy)

^c Casa di Cura Villa Europa all'EUR   (Italy)

^d Unità Operativa di Ostetricia Ginecologia   (Italy)

^e UNIVERSITY OF BARI   (Italy)

^f II Università di Napoli ^*  (Italy)

^g Centro Riproduzione Umana   (Italy)

Author keywords

FSH; IVF; LH; Poor responders; Recombinant human LH

Indexed keywords

ESTRADIOL; GONADORELIN AGONIST; GONASI; PROGESTERONE; RECOMBINANT FOLLITROPIN; RECOMBINANT LUTEINIZING HORMONE; TRIPTORELIN;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CUMULUS OOPHORUS; DRUG DOSE REGIMEN; DRUG EFFICACY; EMBRYO TRANSFER; ESTRADIOL BLOOD LEVEL; FEMALE; FEMALE INFERTILITY; FERTILIZATION IN VITRO; HUMAN; INTRACYTOPLASMIC SPERM INJECTION; MAJOR CLINICAL STUDY; MONOTHERAPY; MULTICENTER STUDY; NIDATION; OVARY FOLLICLE; OVULATION INDUCTION; PREGNANCY RATE; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

EID: 20944441422     PISSN: 02681161     EISSN: None     Source Type: Journal    
DOI: 10.1093/humrep/deh625     Document Type: Article

References (23)

1. Balasch J, Vidal E, Penarrubia J, Casamirjana R, Carmona F, Creus M, Fabregues F and Vanrell JA (2001) Suppression of LH during ovarian stimulation: analysing threshold values and effects on ovarian response and the outcome of assisted reproduction in down-regulated women stimulated with recombinant FSH. Hum Reprod 16,1636-1643.
2. Ben-Amor AF, on behalf of the Study Group (Tarlatzis B, Tavmergen E, Shoham Z, Szamatowicz M, Barash A, Amit A, Levitas I and Geva E) (2000) The effect of luteinising hormone administered during late follicular phase in normo-ovulatory women undergoing in vitro fertilization. Hum Reprod 15,46-50.
3. De Placido G, Mollo A, Alviggi C, Strina I, Varricchio MT, Ranieri A, Colacurci N, Tolino A and Wilding M (2001) Rescue of IVF cycles by HMG in pituitary down-regulated normogonadotrophic young women characterized by a poor initial response to recombinant FSH. Hum Reprod 16,1875-1879.
4. De Placido G, Alviggi C, Mollo A, Strina I, Ranieri A, Alviggi E, Wilding M, Varricchio MT, Borrelli AL and Conforti S (2004) Effects of recombinant LH (rLH) supplementation during controlled ovarian hyperstimulation (COH) in normogonadotrophic women with an initial inadequate response to recombinant FSH (rFSH) after pituitary downregulation. Clin Endocrinol 60,637-643.
5. Filicori M (2003) Use of luteinizing hormone in the treatment of infertility: time for reassessment? Fertil Steril 79,253-255.
6. Filicori M and Cognini E (2001) Roles and novel regimens of luteinising hormone and follicle stimulating hormone in ovulation induction. J Clin Endocrinol Metab 86,1437-1441.
7. Fleming R, Lloyd F, Herbert M, Fenwick J, Griffiths T and Murdoch A (1998) Effects of profound suppression of luteinizing hormone during ovarian stimulation on follicular activity, oocyte and embryo function in cycles stimulated with purified follicle stimulating hormone. Hum Reprod 13,1788-1792.
8. Hughes EG, Fedorkow DM, Daya S, Sagle MA, Van de Koppel P and Collins JA (1992) The routine use of gonadotrophin-releasing hormone agonists prior to in vitro fertilisation and gamete intrafallopian transfer: a meta-analysis of randomised controlled trials. Fertil Steril 58,888-896.
9. Huhtaniemi I, Jiang M, Nilsson C and Pettersson K (1999) Mutations and polymorphisms in gonadotropin genes. Mol Cell Endocrinol 25,89-94.
10. Humaidan P, Bungum L, Bungum M and Andersen CY (2002) Ovarian response and pregnancy outcome related to mid-follicular LH levels in women undergoing assisted reproduction with GnRH agonist down-regulation and recombinant FSH stimulation. Hum Reprod 17,2016-2021.
11. Humaidan P, Bungum L, Bungum M and Andersen CY (2004) Effects of recombinant LH supplementation in women undergoing assisted reproduction with GnRH agonist down-regulation and stimulation with recombinant FSH: an opening study. Reprod Biomed Online 8,635-643.
12. Jiang M, Pakarinen P, Zhang FP, El-Hefnawv T, Koskimies P, Pettersson K and Huhtaniemi I (1999) A common polymorphic allele of the human luteinizing hormone beta-subunit gene: additional mutations and differential function of the promoter sequence. Hum Mol Genet 8,2037-2046.
13. Laml T, Obruca A, Fischl F and Huber J (1999) Recombinant luteinizing hormone in ovarian hyperstimulation after stimulation failure in normogonadotrophic women. Gynecol Endocrinol 13,98-103.
14. Lèvy D, Navarro J, Schattman GL, Davis OK and Rosenwaks Z (2000) The role of LH in ovarian stimulation: exogenous LH, let's design the future. Hum Reprod 15,2258-2265.
15. Lisi F, Rinaldi L, Fishel S, Lisi R, Pepe G, Picconeri MG, Cambell A and Rowe P (2001) Use of recombinant FSH and recombinant LH in multiple follicular stimulation for IVF: a preliminary study. Reprod Biomed Online 3,190-194.
16. Loumaye E, Engrand P, Howles CM and O'Dea L (1997) Assessment of the role of serum luteinising hormone and estradiol response to follicle-stimulating hormone on in vitro fertilisation treatment outcome. Fertil Steril 67,889-899.
17. Marrs R, Meldrum D, Muasher S, Schoolcraft W, Werlin L and Kelly E (2004) Randomized trial to compare the effect of recombinant human FSH (follitropin alfa) with or without recombinant human LH in women undergoing assisted reproduction treatment. Reprod Biomed Online 8,175-182.
18. Mitchell R, Hollis S, Rothwell C and Robertson WR (1995) Age related changes in the pituitary-testicular axis in normal men; lower serum testosterone results from decreased bioactive LH drive. Clin Endocrinol 42, 501-507.
19. Ropelato MG, Garcia-Rudaz MC, Castro-Fernandez C, Ulloa-Aguirre A, Escobar ME, Barontini M and Veldhuis JD (1999) A preponderance of basic luteinizing hormone (LH) isoforms accompanies inappropriate hypersecretion of both basal and pulsatile LH in adolescents with polycystic ovarian syndrome. J Clin Endocrinol Metab 84,4629-4636.
20. Sills SE, Lèvy DP, Moomjy M, McGee M and Rosenwaks Z (1999) A prospective randomised comparison of ovulation induction using highly purified follicle-stimulating hormone alone and with recombinant human luteinizing hormone in in-vitro fertilisation. Hum Reprod 14,2230-2235.
21. Tan SL, Kingsland C, Campbell S, Mills C, Bradfield J, Alexander N, Yovich J and Jacobs HS (1992) The long protocol of administration of gonadotropin-releasing hormone agonist is superior to the short protocol for ovarian stimulation for in vitro fertilisation. Fertil Steril 57,810-814.
22. Westergaard LG, Laursen SB and Andersen CY (2000) Increased risk of early pregnancy loss by profound suppression of luteinizing hormone during ovarian stimulation in normogonadotrophic women undergoing assisted reproduction. Hum Reprod 15,1003-1008.
23. Westergaard LG, Erb K, Laursen SB, Rex S and Rasmaussen PE (2001) Human menopausal gonadotropin versus recombinant follicle-stimulating hormone in normogonadotropic women down-regulated with a gonadotropin-releasing hormone agonist who were undergoing in vitro fertilization and intracytoplasmic sperm injection: a prospective randomized study. Fertil Steril 76,543-549.