Therapeutic hypothermia using gel packs for term neonates with hypoxic ischaemic encephalopathy in resource-limited settings: A randomized controlled trial

Journal of Tropical Pediatrics

Volumn 58, Issue 5, 2012, Pages 382-388

  Bharadwaj, Shruthi K ^a   Vishnu Bhat, B ^a  

^a JAWAHARLAL INSTITUTE OF POSTGRADUATE MEDICAL EDUCATION AND RESEARCH   (India)

Author keywords

Cooling gel packs; Hypoxic ischaemic encephalopathy; Perinatal asphyxia; Resource limited settings; Therapeutic hypothermia

Indexed keywords

ADULT; ARTICLE; BARODA DEVELOPMENTAL SCREENING TEST; CLINICAL ASSESSMENT TOOL; CONTROLLED STUDY; COOLING GEL PACK; DEATH; FEMALE; FOLLOW UP; HUMAN; HYPOXIC ISCHEMIC ENCEPHALOPATHY; INDUCED HYPOTHERMIA; MAJOR CLINICAL STUDY; MALE; MEDICAL DEVICE; NEWBORN; NEWBORN MORBIDITY; NEWBORN MORTALITY; OUTCOME ASSESSMENT; RANDOMIZED CONTROLLED TRIAL; RECTUM TEMPERATURE; STATISTICAL SIGNIFICANCE; TERM BIRTH;

ADULT; ASPHYXIA NEONATORUM; BODY TEMPERATURE; DEVELOPMENTAL DISABILITIES; FEMALE; FOLLOW-UP STUDIES; GELS; HUMANS; HYPOTHERMIA, INDUCED; HYPOXIA-ISCHEMIA, BRAIN; INDIA; INFANT; INFANT, NEWBORN; MALE; SURVIVAL RATE; TREATMENT OUTCOME;

EID: 84867386324     PISSN: 01426338     EISSN: 14653664     Source Type: Journal    
DOI: 10.1093/tropej/fms005     Document Type: Article

References (19)

1. Shankaran S, Woldt E, Koepke T, et al. Acute neonatal morbidity and long-term central nervous system sequelae of perinatal asphyxia in term infants. Early Hum Dev 1991;25:135-48.
2. Wyatt JS, Gluckman PD, Liu PY, et al. Determinants of outcomes after head cooling for neonatal encephalopathy. Pediatrics 2007;119:912-21.
3. Dixon G, Badawi N, Kurinczuk JJ, et al. Early developmental outcomes after newborn encephalopathy. Pediatrics 2002;109:26-33.
4. Thayyil S, Costello A, Shankaran S, Robertson NJ. Therapeutic hypothermia for neonatal encephalopathy implications for neonatal units in India. Indian Pediatr 2009;46:283-9.
5. Horn AR, Woods DL, Thompson C, et al. Selective cerebral hypothermia for post-hypoxic neuroprotection in neonates using a solid ice cap. S Afr Med J 2006; 96(9 Pt 2):976-81.
6. Gunn AJ, Gluckman PD, Gunn TR. Selective head cooling in newborn infants after perinatal asphyxia: a safety study. Pediatrics 1998;102(4 Pt 1):885-92.
7. Akisu M, Huseyinov A, Yalaz M, et al. Selective head cooling with hypothermia suppresses the generation of platelet-activating factor in cerebrospinal fluid of newborn infants with perinatal asphyxia. Prostaglandins Leukot Essent Fatty Acids 2003;69:45-50.
8. Gluckman PD, Wyatt JS, Azzopardi D, et al. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial. Lancet 2005;365:663-70.
9. Zhou W-hao, Cheng G-qiang, Shao X-mei, et al. Selective head cooling with mild systemic hypothermia after neonatal hypoxic-ischemic encephalopathy: a multicenter randomized controlled trial in China. J Pediatr 2010;157:367-72, 372.e1-3.
10. Thomas N, George KC, Sridhar S, et al. Whole body cooling in newborn infants with perinatal asphyxial encephalopathy in a low resource setting: a feasibility trial. Indian Pediatr 2011;48:445-51.
11. Shankaran S, Laptook A, Wright LL, et al. Whole-body hypothermia for neonatal encephalopathy: animal observations as a basis for a randomized, controlled pilot study in term infants. Pediatrics 2002; 110(2 Pt 1):377-85.
12. Shankaran S, Laptook AR, Ehrenkranz RA, et al. Whole-body hypothermia for neonates with hypoxicischemic encephalopathy. N Engl J Med 2005;353: 1574-84.
13. Jacobs SE, Morley CJ, Inder TE, et al. Whole-body hypothermia for term and near-term newborns with hypoxic-ischemic encephalopathy: a randomized controlled trial. Arch Pediatr Adolesc Med 2011;165: 692-700.
14. Shah PS, Ohlsson A, Perlman M. Hypothermia to treat neonatal hypoxic ischemic encephalopathy: systematic review. Arch Pediatr Adolesc Med 2007;161:951-8.
15. Simbruner G, Mittal RA, Rohlmann F, Muche R. Systemic hypothermia after neonatal encephalopathy: outcomes of neo.nEURO.network RCT. Pediatrics 2010;126:e771-8.
16. Li T, Xu F, Cheng X, et al. Systemic hypothermia induced within 10 hours after birth improved neurological outcome in newborns with hypoxic-ischemic encephalopathy. Hosp Pract (Minneap) 2009;37: 147-52.
17. Robertson NJ, Nakakeeto M, Hagmann C, et al. Therapeutic hypothermia for birth asphyxia in low-resource settings: a pilot randomised controlled trial. Lancet 2008;372:801-3.
18. Horn A, Thompson C, Woods D, et al. Induced hypothermia for infants with hypoxic-ischemic encephalopathy using a servo-controlled fan: an exploratory pilot study. Pediatrics 2009;123:e1090-8.
19. Azzopardi DV, Strohm B, Edwards AD, et al. Moderate hypothermia to treat perinatal asphyxial encephalopathy. N Engl J Med 2009;361:1349-58.