Therapeutic hypothermia for neonatal encephalopathy: Implications for neonatal units in India

Indian Pediatrics

Volumn 46, Issue 4, 2009, Pages 283-289

  Thayyil, Sudhin ^a,d   Costello, Anthony ^a   Shankaran, Seetha ^b   Robertson, Nicola Jayne ^c  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d Department of Health ^*  (United Kingdom)

Author keywords

Hypoxic ischemic encephalopathy; Neonate; Therapeutic hypothermia

Indexed keywords

BRAIN DISEASE; BRAIN HYPOXIA; CLINICAL PRACTICE; COST BENEFIT ANALYSIS; HEALTH CARE PLANNING; HUMAN; HYPOTHERMIA; INDIA; INDUSTRIALIZATION; NEWBORN CARE; NEWBORN INTENSIVE CARE; NEWBORN MORTALITY; PHYSICAL DISABILITY; REVIEW; RISK ASSESSMENT;

BRAIN DISEASES; HUMANS; HYPOTHERMIA, INDUCED; INDIA; INFANT, NEWBORN;

EID: 66249130043     PISSN: 00196061     EISSN: 00196061     Source Type: Journal    
DOI: None     Document Type: Review

References (31)

1. Polderman KH. Induced hypothermia and fever control for prevention and treatment of neurological injuries. Lancet 2008; 371: 1955-1969.
2. Jacobs S, Hunt R, Tarnow-Mordi W, Inder T, Davis P. Cooling for newborns with hypoxic ischaemic encephalopathy. Cochrane Database Syst Rev 2007: CD003311.
3. Shah PS, Ohlsson A, Perlman M. Hypothermia to treat neonatal hypoxic ischemic encephalopathy: systematic review. Arch Pediatr Adolesc Med 2007; 161: 951-958. (Pubitemid 47529418)
4. Shankaran S, Laptook AR, Ehrenkranz RA, Tyson JE, McDonald SA, Donovan EF, et al. Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N Engl J Med 2005; 353: 1574-1584.
5. Gluckman PD, Wyatt JS, Azzopardi D, Ballard R, Edwards AD, Ferriero DM, et al. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomized trial. Lancet 2005; 365: 663-670.
6. Eicher DJ, Wagner CL, Katikaneni LP, Hulsey TC, Bass WT, Kaufman DA, et al. Moderate hypothermia in neonatal encephalopathy: efficacy outcomes. Pediatr Neurol 2005; 32: 11-17.
7. Hoehn T, Hansmann G, Buhrer C, Simbruner G, Gunn AJ, Yager J, et al. Therapeutic hypothermia in neonates. Review of current clinical data, ILCOR recommendations and suggestions for implementation in neonatal intensive care units. Resuscitation 2008; 78: 7-12.
8. Cady EB, Costello AM, Dawson MJ, Delpy DT, Hope PL, Reynolds EO, et al. Non-invasive investigation of cerebral metabolism in newborn infants by phosphorus nuclear magnetic resonance spectroscopy. Lancet 1983; 1: 1059-1062.
9. Hope PL, Costello AM, Cady EB, Delpy DT, Tofts PS, Chu A, et al. Cerebral energy metabolism studied with phosphorus NMR spectroscopy in normal and birth-asphyxiated infants. Lancet 1984; 2: 366-370.
10. Tofts PS, Cady EB, Delpy DT, Costello AM, Hope PL, Reynolds EO, et al. Surface coil NMR spectroscopy of brain. Lancet 1984; 1: 459.
11. Thoresen M, Penrice J, Lorek A, Cady EB, Wylezinska M, Kirkbride V, et al. Mild hypo-thermia after severe transient hypoxiaischemia ameliorates delayed cerebral energy failure in the newborn piglet. Pediatr Res 1995; 37: 667-670.
12. Gunn AJ, Gluckman PD, Gunn TR. Selective head cooling in newborn infants after perinatal asphyxia: a safety study. Pediatrics 1998; 102: 885-892. (Pubitemid 28462529)
13. Azzopardi D, Brocklehurst P, Edwards D, Halliday H, Levene M, Thoresen M, et al. The TOBY Study. Whole body hypothermia for the treatment of perinatal asphyxial encephalopathy: a randomized controlled trial. BMC Pediatr 2008; 8: 17.
14. Kirpalani H, Barks J, Thorlund K, Guyatt G. Cooling for neonatal hypoxic ischemic encephalopathy: do we have the answer? Pediatrics 2007; 120: 1126-1130.
15. Ioannidis JP. Contradicted and initially stronger effects in highly cited clinical research. JAMA 2005; 294: 218-228. (Pubitemid 41043792)
16. Perlman M, Shah P. Time to adopt cooling for neonatal hypoxic-ischemic encephalopathy: response to a previous commentary. Pediatrics 2008; 121: 616-618.
17. Azzopardi D, Strohm B, Edwards AD, Halliday H, Juszczak E, Levene MI, et al. Treatment of asphyxiated newborns with moderate hypothermia in routine clinical practice: How cooling is managed in the UK outside a clinical trial. Arch Dis Child Fetal Neonatal Ed 2008; [Epub ahead of print].
18. Kapetanakis A, Azzopardi D, Wyatt J, Robertson NJ. Therapeutic hypothermia for neonatal encephalopathy: a UK survey of opinion, practice and neuro-investigation at the end of 2007. Acta Paediatr 2008; [Epub ahead of print].
19. National Perinatal Neonatal Database. Available from URL: www.newbornwhocc.org/pdf/nnpd-report-2002-03.PDF: Assessed January 16, 2009.
20. Shankaran S, Pappas A, Laptook AR, McDonald SA, Ehrenkranz RA, Tyson JE, et al. Outcomes of safety and effectiveness in a multicenter randomized, controlled trial of whole-body hypothermia for neonatal hypoxic-ischemic encephalopathy. Pediatrics 2008; 122: e791-e798.
21. Lin ZL, Yu HM, Lin J, Chen SQ, Liang ZQ, Zhang ZY. Mild hypothermia via selective head cooling as neuroprotective therapy in term neonates with perinatal asphyxia: an experience from a single neonatal intensive care unit. J Perinatol 2006; 26: 180-184.
22. Mathur NB, Krishnamurthy S, Mishra TK. Evaluation of WHO classification of hypothermia in sick extramural neonates as predictor of fatality. J Trop Pediatr 2005; 51: 341-345. (Pubitemid 43118418)
23. Iwata S, Iwata O, Thornton JS, Shanmugalingam S, Bainbridge A, Peebles D, et al. Superficial brain is cooler in small piglets: neonatal hypothermia implications. Ann Neurol 2006; 60: 578-585.
24. Iwata O, Iwata S, Thornton JS, De Vita E, Bainbridge A, Herbert L, et al. "Therapeutic time window" duration decreases with increasing severity of cerebral hypoxia-ischaemia under normothermia and delayed hypothermia in newborn piglets. Brain Res 2007; 1154: 173-180.
25. Kambarami R, Chidede O. Neonatal hypothermia levels and risk factors for mortality in a tropical country. Cent Afr J Med 2003; 49: 103-106.
26. Burnard ED, Cross KW. Rectal temperature in the newborn after birth asphyxia. Br Med J 1958; 2: 1197-1199.
27. Mathur NB, Krishnamurthy S, Mishra TK. Estimation of rewarming time in transported extramural hypothermic neonates. Indian J Pediatr 2006; 73: 395-399. (Pubitemid 44319479)
28. Horn AR, Woods DL, Thompson C, Eis I, Kroon M. Selective cerebral hypothermia for posthypoxic neuroprotection in neonates using a solid ice cap. S Afr Med J 2006; 96: 976-981.
29. Robertson NJ, Nakakeeto M, Hagmann C, Cowan FM, Acolet D, Iwata O, et al. Therapeutic hypothermia for birth asphyxia in low-resource settings: a pilot randomized controlled trial. Lancet 2008; 372: 801-803.
30. Iwata S, Iwata O, Olson L, Kapetanakis A, Kato T, Evans S, et al. Therapeutic hypothermia can be induced and maintained using either commercial water bottles or a "phase changing material" mattress in a newborn piglet model. Arch Dis Child Fetal Neonatal Ed 2009 [Epub ahead of print]. doi:10.1136/adc.2008.143602.
31. Chalmers I. The scandalous failure of science to cumulate evidence scientifically. Clin Trials 2005; 2: 229-231.