Controlled delivery of thymosin β4 for tissue engineering and cardiac regenerative medicine

Annals of the New York Academy of Sciences

Volumn 1269, Issue 1, 2012, Pages 16-25

  Chiu, Loraine L Y ^a   Reis, Lewis A ^b   Radisic, Milica ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Angiogenesis; Heart; Hydrogel; Peptide; Thymosin 4

Indexed keywords

BIOMATERIAL; CHITOSAN; COLLAGEN; THYMOSIN BETA4;

ANGIOGENESIS; ARTICLE; CELL MIGRATION; CONTROLLED DRUG RELEASE; CULTURE MEDIUM; DRUG DELIVERY SYSTEM; DRUG MECHANISM; DRUG SAFETY; DRUG TOLERABILITY; ENCAPSULATION; ENDOTHELIUM CELL; HEART INFARCTION; HEART LEFT VENTRICLE WALL; HEART PROTECTION; HUMAN; HYDROGEL; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; REGENERATIVE MEDICINE; TISSUE ENGINEERING; VASCULARIZATION;

EID: 84867370435     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2012.06718.x     Document Type: Article

References (42)

1. Morritt, A.N., S.K. Bortolotto, R.J. Dilley, et al 2007. Cardiac tissue engineering in an in vivo vascularized chamber. Circulation 115: 353-360.
2. Caspi, O., A. Lesman, Y. Basevitch, et al 2007. Tissue engineering of vascularized cardiac muscle from human embryonic stem cells. Circ. Res. 100: 263-272.
3. Carrier, R.L., M. Rupnick, R. Langer, et al 2002. Perfusion improves tissue architecture of engineered cardiac muscle. Tissue Eng. 8: 175-188.
4. Radisic, M., A. Marsano, R. Maidhof, et al 2008. Cardiac tissue engineering using perfusion bioreactor systems. Nat. Protoc. 3: 719-738.
5. Radisic, M., J. Malda, E. Epping, et al 2006. Oxygen gradients correlate with cell density and cell viability in engineered cardiac tissue. Biotechnol. Bioeng. 93: 332-343.
6. Bursac, N., M. Papadaki, J.A. White, et al 2003. Cultivation in rotating bioreactors promotes maintenance of cardiac myocyte electrophysiology and molecular properties. Tissue Eng. 9: 1243-1253.
7. Odedra, D., L.L. Chiu, M. Shoichet & M. Radisic 2011. Endothelial cells guided by immobilized gradients of vascular endothelial growth factor on porous collagen scaffolds. Acta Biomater. 7: 3027-3035.
8. Chiu, L.L. & M. Radisic 2010. Scaffolds with covalently immobilized VEGF and Angiopoietin-1 for vascularization of engineered tissues. Biomaterials 31: 226-241.
9. Miyagi, Y., L.L. Chiu, M. Cimini, et al 2011. Biodegradable collagen patch with covalently immobilized VEGF for myocardial repair. Biomaterials 32: 1280-1290.
10. Wu, J., F. Zeng, X.P. Huang, et al 2011. Infarct stabilization and cardiac repair with a VEGF-conjugated, injectable hydrogel. Biomaterials 32: 579-586.
11. Garbern, J.C., E. Minami, P.S. Stayton & C.E. Murry 2011. Delivery of basic fibroblast growth factor with a pH-responsive, injectable hydrogel to improve angiogenesis in infarcted myocardium. Biomaterials 32: 2407-2416.
12. Yu, J., Y. Gu, K.T. Du, et al 2009. The effect of injected RGD modified alginate on angiogenesis and left ventricular function in a chronic rat infarct model. Biomaterials 30: 751-756.
13. Grant, D.S., J.L. Kinsella, M.C. Kibbey, et al 1995. Matrigel induces thymosin beta 4 gene in differentiating endothelial cells. J. Cell. Sci. 108(Pt 12): 3685-3694.
14. Smart, N., C.A. Risebro, A.A. Melville, et al 2007. Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization. Nature 445: 177-182.
15. Grant, D.S., W. Rose, C. Yaen, et al 1999. Thymosin beta4 enhances endothelial cell differentiation and angiogenesis. Angiogenesis 3: 125-135.
16. Bock-Marquette, I., A. Saxena, M.D. White, et al 2004. Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair. Nature 432: 466-472.
17. Smart, N., S. Bollini, K.N. Dube, et al 2011. De novo cardiomyocytes from within the activated adult heart after injury. Nature 474: 640-644.
18. Zhou, B., L.B. Honor, Q. Ma, et al 2012. Thymosin beta 4 treatment after myocardial infarction does not reprogram epicardial cells into cardiomyocytes. J. Mol. Cell Cardiol. 52: 43-47.
19. Tang, M.C., L.C. Chan, Y.C. Yeh, et al 2011. Thymosin beta 4 induces colon cancer cell migration and clinical metastasis via enhancing ILK/IQGAP1/Rac1 signal transduction pathway. Cancer Lett. 308: 162-171.
20. Qian, L., Y. Huang, C.I. Spencer, et al 2012. In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes. Nature 485: 593-598.
21. Ho, J.H., C.H. Chuang, C.Y. Ho, et al 2007. Internalization is essential for the antiapoptotic effects of exogenous thymosin beta-4 on human corneal epithelial cells. Invest. Ophthalmol. Vis. Sci. 48: 27-33.
22. Freeman, K.W., B.R. Bowman & B.R. Zetter 2011. Regenerative protein thymosin beta-4 is a novel regulator of purinergic signaling. FASEB J. 25: 907-915.
23. Philp, D., T. Huff, Y.S. Gho, et al 2003. The actin binding site on thymosin beta4 promotes angiogenesis. FASEB J. 17: 2103-2105.
24. Cha, H.J., M.J. Jeong & H.K. Kleinman 2003. Role of thymosin beta4 in tumor metastasis and angiogenesis. J. Natl. Cancer Inst. 95: 1674-1680.
25. Jo, J.O., S.R. Kim, M.K. Bae, et al 2010. Thymosin beta4 induces the expression of vascular endothelial growth factor (VEGF) in a hypoxia-inducible factor (HIF)-1alpha-dependent manner. Biochim. Biophys. Acta. 1803: 1244-1251.
26. Cavasin, M.A., N.E. Rhaleb, X.P. Yang & O.A. Carretero 2004. Prolyl oligopeptidase is involved in release of the antifibrotic peptide Ac-SDKP. Hypertension 43: 1140-1145.
27. Liu, J.M., F. Lawrence, M. Kovacevic, et al 2003. The tetrapeptide AcSDKP, an inhibitor of primitive hematopoietic cell proliferation, induces angiogenesis in vitro and in vivo. Blood 101: 3014-3020.
28. Wang, D., O.A. Carretero, X.Y. Yang, et al 2004. N-acetyl-seryl-aspartyl-lysyl-proline stimulates angiogenesis in vitro and in vivo. Am. J. Physiol. Heart Circ. Physiol. 287: H2099-H2105.
29. Waeckel, L., J. Bignon, J.M. Liu, et al 2006. Tetrapeptide AcSDKP induces postischemic neovascularization through monocyte chemoattractant protein-1 signaling. Arterioscler. Thromb. Vasc. Biol. 26: 773-779.
30. Brazil, D.P., J. Park & B.A. Hemmings 2002. PKB binding proteins. Getting in on the Akt. Cell 111: 293-303.
31. Rossdeutsch, A., N. Smart & P.R. Riley 2008. Thymosin beta4 and Ac-SDKP: tools to mend a broken heart. J. Mol. Med. 86: 29-35.
32. Crockford, D., N. Turjman, C. Allan & J. Angel 2010. Thymosin beta4: structure, function, and biological properties supporting current and future clinical applications. Ann. N.Y. Acad. Sci. 1194: 179-189.
33. Crockford, D. 2007. Development of thymosin beta4 for treatment of patients with ischemic heart disease. Ann. N.Y. Acad. Sci. 1112: 385-395.
34. Nelson, D.M., Z. Ma, K.L. Fujimoto, et al 2011. Intra-myocardial biomaterial injection therapy in the treatment of heart failure: Materials, outcomes and challenges. Acta Biomater. 7: 1-15.
35. Kretlow, J.D., L. Klouda & A.G. Mikos 2007. Injectable matrices and scaffolds for drug delivery in tissue engineering. Adv. Drug Deliv. Rev. 59: 263-273.
36. Kraehenbuehl, T.P., L.S. Ferreira, P. Zammaretti, et al 2009. Cell-responsive hydrogel for encapsulation of vascular cells. Biomaterials 30: 4318-4324.
37. Kraehenbuehl, T.P., L.S. Ferreira, A.M. Hayward, et al 2011. Human embryonic stem cell-derived microvascular grafts for cardiac tissue preservation after myocardial infarction. Biomaterials 32: 1102-1109.
38. Chiu, L.L. & M. Radisic 2011. Controlled release of thymosin beta4 using collagen-chitosan composite hydrogels promotes epicardial cell migration and angiogenesis. J. Control Release 155: 376-385.
39. Wang, X., L. Sang, D. Luo & X. Li 2011. From collagen-chitosan blends to three-dimensional scaffolds: the influences of chitosan on collagen nanofibrillar structure and mechanical property. Colloids. Surf. B. Biointerfaces 82: 233-240.
40. Leor, J., S. Tuvia, V. Guetta, et al 2009. Intracoronary injection of in situ forming alginate hydrogel reverses left ventricular remodeling after myocardial infarction in Swine. J. Am. Coll. Cardiol. 54: 1014-1023.
41. Wall, S.T., J.C. Walker, K.E. Healy, et al 2006. Theoretical impact of the injection of material into the myocardium: a finite element model simulation. Circulation 114: 2627-2635.
42. Chiu, L.L., L.A. Reis, A. Momen, & M. Radisic 2012. Controlled release of thymosin beta4 from injected collagen-chitosan hydrogels promotes angiogenesis and prevents tissue loss after myocardial infarction. Regen. Med. 7: 523-533.